Zobrazeno 1 - 10
of 430
pro vyhledávání: '"Yutaka, Aoyagi"'
Autor:
Hiroyuki Abe, Kenya Kamimura, Shujiro Okuda, Yu Watanabe, Jun Inoue, Yutaka Aoyagi, Toshifumi Wakai, Ryo Kominami, Shuji Terai
Publikováno v:
Cancer Medicine, Vol 12, Iss 14, Pp 15650-15663 (2023)
Abstract Introduction B‐cell lymphoma/leukemia 11B (BCL11B) is a subunit of SWI/SNF chromatin remodeling complexes and functions in cell cycle regulation and apoptosis upon DNA replication stress and damages via transcription. Many malignancies wer
Externí odkaz:
https://doaj.org/article/b28136d80b664370b096168307a180cc
Autor:
Kenya Kamimura, Tsutomu Kanefuji, Takeshi Suda, Takeshi Yokoo, Guisheng Zhang, Yutaka Aoyagi, Dexi Liu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 903-913 (2023)
Hydrodynamics-based gene transfer has been successfully employed for in vivo gene delivery to the liver of small animals by tail vein injection and of large animals using a computer-assisted and image-guided protocol. In an effort to develop a hydrod
Externí odkaz:
https://doaj.org/article/d2e1e76ad0ef44c494e670b26a7f8fe2
Autor:
Naruhiro Kimura, Toru Setsu, Yoshihisa Arao, Norihiro Sakai, Yusuke Watanabe, Hiroyuki Abe, Hiroteru Kamimura, Akira Sakamaki, Takeshi Yokoo, Kenya Kamimura, Atsunori Tsuchiya, Akihiko Osaki, Kentarou Igarashi, Nobuo Waguri, Masahiko Yanagi, Toru Takahashi, Soichi Sugitani, Yuka Kobayashi, Masaaki Takamura, Akira Yoshikawa, Toru Ishikawa, Toshiaki Yoshida, Toshiaki Watanabe, Hitoshi Bannai, Tomoyuki Kubota, Kazuhiro Funakoshi, Hiroto Wakabayashi, So Kurita, Norio Ogata, Masashi Watanabe, Yuhsaku Mita, Shigeki Mori, Motoya Sugiyama, Toru Miyajima, Sumio Takahashi, Shuichi Sato, Kisei Ishizuka, Hironobu Ohta, Yutaka Aoyagi, Shuji Terai
Publikováno v:
JGH Open, Vol 6, Iss 8, Pp 577-586 (2022)
Abstract Background and Aim Symptoms of primary biliary cholangitis (PBC) frequently impair one's quality of life (QOL). Nonetheless, with improved treatment, the prognosis of PBC also improves. QOL plays an important role in patients with PBC. In th
Externí odkaz:
https://doaj.org/article/00155ff6b17b4c6ea105600566ce3d49
Autor:
Kenya Kamimura, Takeshi Suda, Yasuo Fukuhara, Shujiro Okuda, Yu Watanabe, Takeshi Yokoo, Akihiko Osaki, Nobuo Waguri, Toru Ishikawa, Toshihiro Sato, Yutaka Aoyagi, Masaaki Takamura, Toshifumi Wakai, Shuji Terai
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Cisplatin (CDDP) is one of the chemotherapeutic drugs being used to treat various cancers. Although effective in many cases, as high doses of CDDP cause cytotoxic effects that may worsen patients’ condition, therefore, a marker of sensitiv
Externí odkaz:
https://doaj.org/article/79557776ef4640ec831b2db676818deb
Autor:
Akira Sakamaki, Masaaki Takamura, Norihiro Sakai, Yusuke Watanabe, Yoshihisa Arao, Naruhiro Kimura, Toru Setsu, Hiroyuki Abe, Takeshi Yokoo, Hiroteru Kamimura, Shunsuke Tsubata, Nobuo Waguri, Toru Ishikawa, Hirokazu Kawai, Soichi Sugitani, Tomomi Sato, Kazuhiro Funakoshi, Masashi Watanabe, Kentarou Igarashi, Kenya Kamimura, Atsunori Tsuchiya, Yutaka Aoyagi, Shuji Terai
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0263464 (2022)
Due to the developments in the treatment for hepatitis, it is possible to prevent the progression of liver fibrosis and improve patients' prognosis even if it has already led to liver cirrhosis (LC). Consequently, a two-step study was conducted. To b
Externí odkaz:
https://doaj.org/article/8a6311bc1dd14a26a74fee6f948e59ea
Autor:
Kohei Ogawa, Kenya Kamimura, Yuji Kobayashi, Hiroyuki Abe, Takeshi Yokoo, Norihiro Sakai, Takuro Nagoya, Akira Sakamaki, Satoshi Abe, Kazunao Hayashi, Satoshi Ikarashi, Junji Kohisa, Masanori Tsuchida, Yutaka Aoyagi, Guisheng Zhang, Dexi Liu, Shuji Terai
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 9, Iss C, Pp 80-88 (2017)
Development of an effective, safe, and convenient method for gene delivery to the pancreas is a critical step toward gene therapy for pancreatic diseases. Therefore, we tested the possibility of applying the principle of hydrodynamic gene delivery fo
Externí odkaz:
https://doaj.org/article/5e516df0cd104238ada376bb8d56549b
Autor:
YoungSook Yun, Mariko Shioura, Yukio Hitotsuyanagi, Satoshi Yotsumoto, Yuji Takahashi, Yutaka Aoyagi, Takeshi Kinoshita, Koichi Takeya, Hideshi Inoue
Publikováno v:
Molecules, Vol 26, Iss 9, p 2422 (2021)
Cytotoxicity and apoptosis-inducing properties of compounds isolated from Garcinia subelliptica leaves were investigated. The hexane-soluble portion of MeOH extracts of G. subelliptica leaves that showed cytotoxic activity was separated to yield seve
Externí odkaz:
https://doaj.org/article/63cc91acb9fb486988d8695d648cddc8
Autor:
Yutaka Aoyagi, Koji Fujiwara, Yoshinao Takahashi, Reiko Yano, Yukio Hitotsuyanagi, Koichi Takeya, Ritsuo Aiyama, Takeshi Matsuzaki, Shusuke Hashimoto, Aki Nishihara-Tsukashima, Miyuki Namatame, Aki Ishiyama, Masato Iwatsuki, Kazuhiko Otoguro, Haruki Yamada, Satoshi Ōmura
Publikováno v:
Chemical and Pharmaceutical Bulletin. 70:300-303
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d86e56ecbe653e5886628d1d0685a38
https://doi.org/10.1248/cpb.c21-00998
https://doi.org/10.1248/cpb.c21-00998
Autor:
Kenji Suzuki, Somasundaram Arumugam, Junji Yokoyama, Yusuke Kawauchi, Yutaka Honda, Hiroki Sato, Yutaka Aoyagi, Shuji Terai, Kazuichi Okazaki, Yasuo Suzuki, Shuji Mizumoto, Kazuyuki Sugahara, Raja Atreya, Markus F Neurath, Kenichi Watanabe, Taishi Hashiguchi, Hiroyuki Yoneyama, Hitoshi Asakura
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158967 (2016)
Induction of mucosal healing (MH) is an important treatment goal in inflammatory bowel disease (IBD). Although the molecular mechanisms underlying MH in IBD is not fully explored, local fibrosis would contribute to interfere mucosal repair. Carbohydr
Externí odkaz:
https://doaj.org/article/bdc39cdabfa94c89bba24d1bfc1d6290
Autor:
Yuji Kobayashi, Kenya Kamimura, Hiroyuki Abe, Takeshi Yokoo, Kohei Ogawa, Yoko Shinagawa-Kobayashi, Ryo Goto, Ryosuke Inoue, Masato Ohtsuka, Hiromi Miura, Tsutomu Kanefuji, Takeshi Suda, Masanori Tsuchida, Yutaka Aoyagi, Guisheng Zhang, Dexi Liu, Shuji Terai
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Hydrodynamic gene delivery is a common method for gene transfer to the liver of small animals, and its clinical applicability in large animals has been demonstrated. Previous studies focused on functional analyses of therapeutic genes in animals with
Externí odkaz:
https://doaj.org/article/bd47aac2c9bc46bd8ee49e0bb643f102