Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Yuta Shimanaka"'
Autor:
Sari Sugahara, Yuki Ishino, Koki Sawada, Tsumugi Iwata, Yuta Shimanaka, Junken Aoki, Hiroyuki Arai, Nozomu Kono
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 11, Pp 100443- (2023)
Phosphatidylserine (PS) is an acidic phospholipid that is involved in various cellular events. Heterologous dominant mutations have been identified in the gene encoding PS synthase 1 (PSS1) in patients with a congenital disease called Lenz-Majewski s
Externí odkaz:
https://doaj.org/article/65aeb195de3f4f9ab3916345f171d867
Omega-3 fatty acid epoxides produced by PAF-AH2 in mast cells regulate pulmonary vascular remodeling
Autor:
Hidenori Moriyama, Jin Endo, Masaharu Kataoka, Yuta Shimanaka, Nozomu Kono, Yuki Sugiura, Shinichi Goto, Hiroki Kitakata, Takahiro Hiraide, Naohiro Yoshida, Sarasa Isobe, Tsunehisa Yamamoto, Kohsuke Shirakawa, Atsushi Anzai, Yoshinori Katsumata, Makoto Suematsu, Kenjiro Kosaki, Keiichi Fukuda, Hiroyuki Arai, Motoaki Sano
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Pulmonary hypertension is a fatal disease that causes right heart failure due to pulmonary artery stenosis. Here, the authors find that ω-3 epoxides produced by the phospholipase PAF-AH2 in mast cells regulate pulmonary vascular remodeling.
Externí odkaz:
https://doaj.org/article/bf596d8cbe734fc7b41acec18cce7abc
Autor:
Yuta Shimanaka, Keiko Matsumoto, Yuki Tanaka, Yuki Ishino, Shenwei Ni, Jun-Lin Guan, Hiroyuki Arai, Nozomu Kono
Publikováno v:
Communications Chemistry, Vol 5, Iss 1, Pp 1-10 (2022)
Phosphoinositide (PIP) species play important roles in a number of cellular events, but the simultaneous quantification of individual PIP species remains challenging using conventional methods. Here, the authors report a supercritical fluid chromatog
Externí odkaz:
https://doaj.org/article/caf2da6812934241b23ddaa97142df8d
Autor:
Tsunehisa Yamamoto, Jin Endo, Masaharu Kataoka, Tomohiro Matsuhashi, Yoshinori Katsumata, Kohsuke Shirakawa, Naohiro Yoshida, Sarasa Isobe, Hidenori Moriyama, Shinichi Goto, Kaoru Yamashita, Hiroki Nakanishi, Yuta Shimanaka, Nozomu Kono, Ken Shinmura, Hiroyuki Arai, Keiichi Fukuda, Motoaki Sano
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208396 (2018)
Increase in saturated fatty acid (SFA) content in membrane phospholipids dramatically affects membrane properties and cellular functioning. We sought to determine whether exogenous SFA from the diet directly affects the degree of membrane phospholipi
Externí odkaz:
https://doaj.org/article/1da804dffc904fbfbf59400936414a28
Autor:
Kevin Qian, Marcus J. Tol, Jin Wu, Lauren F. Uchiyama, Xu Xiao, Liujuan Cui, Alexander H. Bedard, Thomas A. Weston, Pradeep S. Rajendran, Laurent Vergnes, Yuta Shimanaka, Yesheng Yin, Yasaman Jami-Alahmadi, Whitaker Cohn, Bryce T. Bajar, Chia-Ho Lin, Benita Jin, Laura A. DeNardo, Douglas L. Black, Julian P. Whitelegge, James A. Wohlschlegel, Karen Reue, Kalyanam Shivkumar, Feng-Jung Chen, Stephen G. Young, Peng Li, Peter Tontonoz
Publikováno v:
Nature
Multilocular adipocytes are a hallmark of thermogenic adipose tissue(1,2), but the factors that enforce this cellular phenotype are largely unknown. Here, we show that an adipocyte-selective product of the Clstn3 locus (CLSTN3β) present in only plac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d398f0ffd1d3e335b793aade13ff43e3
https://doi.org/10.1038/s41586-022-05507-1
https://doi.org/10.1038/s41586-022-05507-1
Autor:
Hiroshi Tachibana, Kodai Minoura, Tomohiro Omachi, Kohjiro Nagao, Takafumi Ichikawa, Yasuhisa Kimura, Nozomu Kono, Yuta Shimanaka, Hiroyuki Arai, Kazumitsu Ueda, Noriyuki Kioka
Publikováno v:
Journal of Cell Science; Aug2023, Vol. 136 Issue 16, p1-11, 11p
Autor:
Rita Romani, Nozomu Kono, Stefano Giovagnoli, Carla Emiliani, F. Morena, Lorena Urbanelli, Krizia Sagini, Sandra Buratta, Marco Gargaro, Yuta Shimanaka, Hiroyuki Arai, Eva Costanzi, S. Ni
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
Extracellular vesicles (EVs) are well-known mediators in intercellular communication playing pivotal roles in promoting liver inflammation and fibrosis, events associated to hepatic lipotoxicity caused by saturated free fatty acid overloading. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0adff90e13dcce4ef020b863bac5057
https://doaj.org/article/a6d1b94e294d4a239d5ffe634057b60f
https://doaj.org/article/a6d1b94e294d4a239d5ffe634057b60f
Autor:
Takuya Kubo, Toshimasa Yamauchi, Naoto Kubota, Panu K. Luukkonen, Yuki Tanaka, Yanli Mao, Jussi Pihlajamäki, Luca Valenti, Yuta Shimanaka, Andrea Caddeo, Rosellina Margherita Mancina, Hiroyuki Arai, Nozomu Kono, Guido Baselli, Tetsuya Kubota, Hannele Yki-Järvinen, Stefano Romeo
Publikováno v:
Gut
ObjectiveNon-alcoholic fatty liver disease (NAFLD) is a common prelude to cirrhosis and hepatocellular carcinoma. The genetic rs641738 C>T variant in the lysophosphatidylinositol acyltransferase 1 (LPIAT1)/membrane bound O-acyltransferase domain-cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750181e50d399b03d39c3d98072b77b7
https://doi.org/10.1136/gutjnl-2020-320646
https://doi.org/10.1136/gutjnl-2020-320646
Autor:
Ken Shinmura, Tsunehisa Yamamoto, Masaharu Kataoka, Shinichi Goto, Hidenori Moriyama, Hiroyuki Arai, Keiichi Fukuda, Motoaki Sano, Kohsuke Shirakawa, Sarasa Isobe, Jin Endo, Yuta Shimanaka, Nozomu Kono, Yoshinori Katsumata
Publikováno v:
Archives of Medical Science.
IntroductionLipotoxicity due to obesity is known to lead to cardiac dysfunction. In an earlier study, we found that an increase in the ratio of saturated fatty acids (SFA) to monounsaturated fatty acids (MUFA) in the membrane of cardiomyocytes causes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90497af39a322432fdfd721e362f749a
https://doi.org/10.5114/aoms/142428
https://doi.org/10.5114/aoms/142428
Autor:
Hiroki Nakanishi, Kaoru Yamashita, Shinichi Goto, Jin Endo, Hiroyuki Arai, Ken Shinmura, Motoaki Sano, Yuta Shimanaka, Nozomu Kono, Yoshinori Katsumata, Keiichi Fukuda, Hidenori Moriyama, Tsunehisa Yamamoto, Sarasa Isobe, Masaharu Kataoka, Tomohiro Matsuhashi, Naohiro Yoshida, Kohsuke Shirakawa, Takayo Ohto-Nakanishi
Publikováno v:
Journal of Molecular and Cellular Cardiology. 133:1-11
Background The fatty acid (FA) composition of membrane phospholipid reflects at least in part dietary fat composition. Saturated FA (SFA) suppress Sirt1 activity, while monounsaturated FA (MUFA) counteract this effect. Objective We explored a role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98520b1564db1483c92849ab8c13745b
https://doi.org/10.1016/j.yjmcc.2019.05.019
https://doi.org/10.1016/j.yjmcc.2019.05.019