Výsledky vyhledávání - "Yuta Morisaki"

Akademický článek

Depletion of perivascular macrophages delays ALS disease progression by ameliorating blood-spinal cord barrier impairment in SOD1G93A mice

Autor: Kazuki Adachi, Kota Miyata, Yukino Chida, Mikako Hirose, Yuta Morisaki, Koji Yamanaka, Hidemi Misawa

Publikováno v: Frontiers in Cellular Neuroscience, Vol 17 (2023)

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease in which non-cell-autonomous processes have been proposed as its cause. Non-neuronal cells that constitute the environment around motor neurons are known to mediate the pathogenesis

Externí odkaz: https://doaj.org/article/fd201da49db041519349c083f82cb56f

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Akademický článek

LAG-3 expression in microglia regulated by IFN-γ/STAT1 pathway and metalloproteases

Autor: Yuta Morisaki, Motoki Ohshima, Hikaru Suzuki, Hidemi Misawa

Publikováno v: Frontiers in Cellular Neuroscience, Vol 17 (2023)

Microglia are resident innate immune cells in the central nervous system (CNS) and play important roles in the development of CNS homeostasis. Excessive activation and neurotoxicity of microglia are observed in several CNS disorders, but the mechanis

Externí odkaz: https://doaj.org/article/372cadc50e5f4df7a40f9f17dd750c02

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[Motor neuron heterogeneity and selective vulnerability in ALS]

Autor: Hidemi Misawa, Yuta Morisaki

Publikováno v: Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 152(2)

Different and selective vulnerability among motor neuron subtypes are a fundamental, but unexplained, feature of amyotrophic lateral sclerosis (ALS): fast-fatigable (FF) motor neurons are the most vulnerable, and fast fatigue-resistant/slow (FR/S) mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29646f6e23fa3d575addae93b2857b82
https://pubmed.ncbi.nlm.nih.gov/30101862

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Selective Expression of Osteopontin in ALS-resistant Motor Neurons is a Critical Determinant of Late Phase Neurodegeneration Mediated by Matrix Metalloproteinase-9

Autor: Koji Yamanaka, Sae Uchida, Shinji Ohara, Takashi Okuda, Mamiko Niikura, Yuta Morisaki, Shogo Tanabe, Shigeo Murayama, Mizuho Watanabe, Masaki Takao, Kosuke Onishi, Hidemi Misawa, Yasuhiro Moriwaki

Publikováno v: Scientific Reports

Differential vulnerability among motor neuron (MN) subtypes is a fundamental feature of amyotrophic lateral sclerosis (ALS): fast-fatigable (FF) MNs are more vulnerable than fast fatigue-resistant (FR) or slow (S) MNs. The reason for this selective v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1598f01b02e8848586b5e2d683e7f7
http://europepmc.org/articles/PMC4893611

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Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes

Autor: Fuminori Sakurai, Norihisa Furukawa, Kazuo Imagawa, Masashi Tachibana, Ryo Sumazaki, Kenji Kawabata, Yuta Morisaki, Kazuo Harada, Yasuhito Nagamoto, Mahito Nakanishi, Shuichi Kuno, Hiroyuki Mizuguchi, Manami Ohtaka, Emiko Noguchi, Ken Nishimura, Kazuo Takayama, Kazumasa Hirata

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 111(47)

Interindividual differences in hepatic metabolism, which are mainly due to genetic polymorphism in its gene, have a large influence on individual drug efficacy and adverse reaction. Hepatocyte-like cells (HLCs) differentiated from human induced pluri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a1e205f380addc096d84195af1d208
https://pubmed.ncbi.nlm.nih.gov/25385620

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