Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Yuta Hara"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 153, Iss 3, Pp 89-93 (2023)
Increasing evidence indicates that immune abnormalities are associated with the pathogenesis of depression. CCR4 is a chemokine receptor that regulates regulatory T cell (Treg) and Th17 cell migration. Here, using a lipopolysaccharide (LPS)-induced d
Externí odkaz:
https://doaj.org/article/b030da1166644bad92b570794a6a2618
Autor:
Akitaka Yamasaki, Rikuto Miyake, Yuta Hara, Hideki Okuno, Takuya Imaida, Kouki Okita, Shogo Okazaki, Yasutoshi Akiyama, Kenji Hirotani, Yuichi Endo, Kazue Masuko, Takashi Masuko, Yoshihisa Tomioka
Publikováno v:
Cancer Medicine, Vol 12, Iss 8, Pp 9684-9696 (2023)
Abstract Background Colorectal cancer (CRC) is the most common malignancy in the world, and novel molecular targeted therapies for CRC have been vigorously pursued. We searched for novel combination therapies based on the expression patterns of membr
Externí odkaz:
https://doaj.org/article/77ea5f9525074b0dbd229b20ff2ad641
Autor:
Momo Kamei, Kazuhiko Matsuo, Haruka Imanishi, Yuta Hara, Ying-Shu Quen, Fumio Kamiyama, Naoki Oiso, Akira Kawada, Naoki Okada, Takashi Nakayama
Publikováno v:
Journal of Pharmacological Sciences, Vol 143, Iss 3, Pp 182-187 (2020)
Memory CD8+ cytotoxic T-lymphocytes (CTLs) play a key role in protective immunity against infection and cancer. However, the induction of memory CTLs with currently available vaccines remains difficult. The chemokine receptor XCR1 is predominantly ex
Externí odkaz:
https://doaj.org/article/6de5574a618a41fa85bc6d011c3aa815
Autor:
Yuta Hara, Yushi Minami, Soshi Yoshimoto, Natsumi Hayashi, Akitaka Yamasaki, Shiho Ueda, Kazue Masuko, Takashi Masuko
Publikováno v:
Cancer Medicine, Vol 9, Iss 1, Pp 302-312 (2020)
Abstract KRAS mutations are detected in numerous human cancers, but there are few effective drugs for KRAS‐mutated cancers. Transporters for amino acids and glucose are highly expressed on cancer cells, possibly to maintain rapid cell growth and me
Externí odkaz:
https://doaj.org/article/d28fe059c62a4d368b36870926a7cf70
Autor:
Kazuhiko Matsuo, Shota Hatanaka, Yuta Kimura, Yuta Hara, Keiji Nishiwaki, Ying-Shu Quan, Fumio Kamiyama, Naoki Oiso, Akira Kawada, Kenji Kabashima, Takashi Nakayama
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 109, Iss , Pp 1437-1444 (2019)
CCR4 is a chemokine receptor highly expressed by Th2 cells, and regarded as a potential therapeutic target for atopic dermatitis (AD). CCL17 and CCL22 are the CCR4 ligands, and thymic stromal lymphopoietin (TSLP) is shown to promote the expression of
Externí odkaz:
https://doaj.org/article/d529f0a21f75482e8ecfc65e4cdcf2c5
Autor:
Kosuke Kitahata, Kazuhiko Matsuo, Yuta Hara, Takanori Naganuma, Naoki Oiso, Akira Kawada, Takashi Nakayama
Publikováno v:
Journal of Pharmacological Sciences, Vol 138, Iss 4, Pp 284-288 (2018)
Psoriasis is a chronic inflammatory skin disease in which inflammatory cytokines play a major role in its pathogenesis. Because DDH-1, a novel amphipathic ascorbic acid derivative, has been recently shown to reduce inflammatory cytokine expression in
Externí odkaz:
https://doaj.org/article/f4d11687e79a425fb42f420d6dc5c6c4
Autor:
Yuta Hara, Yukio Ago, Erika Takano, Shigeru Hasebe, Takanobu Nakazawa, Hitoshi Hashimoto, Toshio Matsuda, Kazuhiro Takuma
Publikováno v:
Molecular Autism, Vol 8, Iss 1, Pp 1-9 (2017)
Abstract Background MicroRNAs, small non-coding RNAs, are highly expressed in the mammalian brain, and the dysregulation of microRNA levels may be involved in neurodevelopmental disorders such as autism spectrum disorder (ASD). In the present study,
Externí odkaz:
https://doaj.org/article/cee650c649374e6dadc7f773cef4e6ec
Autor:
Kazuhiko Matsuo, Kosuke Kitahata, Fumika Kawabata, Momo Kamei, Yuta Hara, Shiki Takamura, Naoki Oiso, Akira Kawada, Osamu Yoshie, Takashi Nakayama
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The chemokine receptor XCR1 is known to be selectively expressed by cross-presenting dendritic cells (DCs), while its ligand XCL1/lymphotactin is mainly produced by activated CD8+ T cells and natural killer cells. Recent studies have shown that XCL1-
Externí odkaz:
https://doaj.org/article/aedb6e403de447a3abb34fee31bcd202
Publikováno v:
Journal of Pharmacological Sciences, Vol 118, Iss 4, Pp 543-546 (2012)
We have recently shown that prenatal valproic acid (VPA) exposure causes autism spectrum disorders–like behavioral abnormalities and Nissl-positive cell loss in both prefrontal and somatosensory cortices in male mice. We have also found that VPA-in
Externí odkaz:
https://doaj.org/article/47c953fc10904b5dbc7fa74492126df7
Autor:
Akitaka Yamasaki, Rikuto Miyake, Yuta Hara, Hideki Okuno, Takuya Imaida, Kouki Okita, Shogo Okazaki, Yasutoshi Akiyama, Kenji Hirotani, Yuichi Endo, Kazue Masuko, Takashi Masuko, Yoshihisa Tomioka
Publikováno v:
Cancer Medicine. 12:9684-9696
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aab665de2823f44a1527c0719171bf31
https://doi.org/10.1002/cam4.5673
https://doi.org/10.1002/cam4.5673