Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Yuta, Yanase"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 150, Iss 4, Pp 233-243 (2022)
N-Methyl-D-aspartate receptors (NMDARs) in the brain are influenced by psychoactive drugs such as 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one (ketamine) and its analog 2-(ethylamino)-2-(3-methoxyphenyl)-cyclohexanone (methoxetamine). The recre
Externí odkaz:
https://doaj.org/article/fc93e92edd564969b33ee9c3eb0669f2
Publikováno v:
MATERIALS TRANSACTIONS. 64:1125-1134
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b8fc4c4726880f7255c71fbb1613710
https://doi.org/10.2320/matertrans.mt-me2022003
https://doi.org/10.2320/matertrans.mt-me2022003
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 12, p 6847 (2022)
Stimulator of Interferon Genes (STING) is a type of endoplasmic reticulum (ER)-membrane receptor. STING is activated by a ligand binding, which leads to an enhancement of the immune-system response. Therefore, a STING ligand can be used to regulate t
Externí odkaz:
https://doaj.org/article/abba75019b0947798afa2063d7ce93a0
Autor:
Mami Takyo, Yumi Sato, Naoya Hirata, Keisuke Tsuchiya, Hiroaki Ishida, Takashi Kurohara, Yuta Yanase, Takahito Ito, Yasunari Kanda, Keiko Yamamoto, Takashi Misawa, Yosuke Demizu
Publikováno v:
ACS Omega. 7(50):46573-46582
The vitamin D receptor (VDR) is a nuclear receptor, which is involved in several physiological processes, including differentiation and bone homeostasis. The VDR is a promising target for the development of drugs against cancer and bone-related disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cae905381b7eb59715143fed360a172
https://ousar.lib.okayama-u.ac.jp/64268
https://ousar.lib.okayama-u.ac.jp/64268
Publikováno v:
MATERIALS TRANSACTIONS. 63:176-184
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b97f20e52a37cb803e447bdc12e72c9b
https://doi.org/10.2320/matertrans.mt-m2021215
https://doi.org/10.2320/matertrans.mt-m2021215
Autor:
Yuki Murakami, Hinata Osawa, Takashi Kurohara, Yuta Yanase, Takahito Ito, Hidetomo Yokoo, Norihito Shibata, Mikihiko Naito, Kosuke Aritake, Yosuke Demizu
Publikováno v:
RSC Medicinal Chemistry. 13:1495-1503
SAR studies of PROTACs that target H-PGDS, focusing on the E3 ligase ligand and the H-PGDS ligand, are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e077833a5ea1afdf4b6a4883f35896f
https://doi.org/10.1039/d2md00284a
https://doi.org/10.1039/d2md00284a
Autor:
Norihito Shibata, Mikihiko Naito, Takahito Ito, Yuta Yanase, Yasushi Saeki, Kengo Hamamura, Kiyonaga Fujii, Hidetomo Yokoo, Yosuke Demizu, Yuki Murakami, Akinori Endo, Kosuke Aritake
Publikováno v:
Journal of Medicinal Chemistry. 64:15868-15882
Targeted protein degradation by proteolysis-targeting chimera (PROTAC) is one of the exciting modalities for drug discovery and biological discovery. It is important to select an appropriate linker, an E3 ligase ligand, and a target protein ligand in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1366e89ebdea025c49ace72bba087d
https://doi.org/10.1021/acs.jmedchem.1c01206
https://doi.org/10.1021/acs.jmedchem.1c01206
Publikováno v:
Journal of Japan Institute of Light Metals. 72:88-90
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0655bb7eb0def4353815152b725e6ca4
https://doi.org/10.2464/jilm.72.88
https://doi.org/10.2464/jilm.72.88
Autor:
Hidetomo Yokoo, Norihito Shibata, Akinori Endo, Takahito Ito, Yuta Yanase, Yuki Murakami, Kiyonaga Fujii, Yasushi Saeki, Mikihiko Naito, Kosuke Aritake, Yosuke Demizu
Hematopoietic prostaglandin D synthase (H-PGDS) is an attractive target for the development of therapeutic agents for Duchenne muscular dystrophy (DMD) and other H-PGDS-related diseases. We have recently developed the H-PGDS degrader PROTAC(H-PGDS)-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b2c9242356279093dfc122690cc54a
https://doi.org/10.26434/chemrxiv.14739486
https://doi.org/10.26434/chemrxiv.14739486
Autor:
Genichiro Tsuji, Yosuke Demizu, Katsuhiko Hayashi, Kentaro Ikeda, Yukiko Hara-Kudo, Yuta Yanase
Publikováno v:
Bioorganicmedicinal chemistry letters. 32
Bacteria can form a biofilm composed of diverse bacterial microorganism, which work as a barrier to protect from threats, such as antibiotics and host immunity system. The formation of biofilms significantly impairs the efficacy of antibiotics agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b436b49297d17040499c8d10ce26d4
https://pubmed.ncbi.nlm.nih.gov/33271284
https://pubmed.ncbi.nlm.nih.gov/33271284