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Akademický článek

NOT gated T cells that selectively target EGFR and other widely expressed tumor antigens

Autor: Julyun Oh, Charles Kirsh, Jing-Ping Hsin, Kelly C. Radecki, Alexandre Zampieri, Diane Manry, Yuta Ando, Sara Miller, Jamie Chan, Ethan McLeod, Kathleen M. Cunningham, Lu Min Wong, Han Xu, Alexander Kamb

Publikováno v: iScience, Vol 27, Iss 6, Pp 109913- (2024)

Summary: Here, we show that a NOT gated cell therapy (Tmod) can exploit antigens such as epidermal growth factor receptor (EGFR) and human leukocyte antigen-E (HLA-E) which are widely expressed on cancer cells. Noncancerous cells—despite high expre

Externí odkaz: https://doaj.org/article/2f54004c83044be5bd8ac35ee92cdfc3

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Akademický článek

Edge-localized alteration in pluripotency state of mouse ES cells forming topography-confined layers on designed mesh substrates

Autor: Yuta Ando, Kennedy Omondi Okeyo, Junko Sunaga, Taiji Adachi

Publikováno v: Stem Cell Research, Vol 53, Iss , Pp 102352- (2021)

Self-organization of pluripotent stem cells during tissue formation is directed by the adhesion microenvironment, which defines the resulting tissue topography. Although the influence of tissue topography on pluripotency state has been inferred, this

Externí odkaz: https://doaj.org/article/2c8ff876bba942969391b63f6d5167dc

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Akademický článek

Non-invasive Optical Biomarkers Distinguish and Track the Metabolic Status of Single Hematopoietic Stem Cells

Autor: Hao Zhou, Lisa Nguyen, Cosimo Arnesano, Yuta Ando, Manmeet Raval, Joseph T. Rodgers, Scott Fraser, Rong Lu, Keyue Shen

Publikováno v: iScience, Vol 23, Iss 2, Pp - (2020)

Summary: Metabolism is a key regulator of hematopoietic stem cell (HSC) functions. There is a lack of real-time, non-invasive approaches to evaluate metabolism in single HSCs. Using fluorescence lifetime imaging microscopy, we developed a set of meta

Externí odkaz: https://doaj.org/article/6411ab9c0dc14f859f5fd031273b4366

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Akademický článek

Engineering a Vascularized Hypoxic Tumor Model for Therapeutic Assessment

Autor: Yuta Ando, Jeong Min Oh, Winfield Zhao, Madeleine Tran, Keyue Shen

Publikováno v: Cells, Vol 10, Iss 9, p 2201 (2021)

Solid tumors in advanced cancer often feature a structurally and functionally abnormal vasculature through tumor angiogenesis, which contributes to cancer progression, metastasis, and therapeutic resistances. Hypoxia is considered a major driver of a

Externí odkaz: https://doaj.org/article/ca65491b51754bb8aef932f6838596a6

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Akademický článek

Modulation of adhesion microenvironment using mesh substrates triggers self-organization and primordial germ cell-like differentiation in mouse ES cells

Autor: Yuta Ando, Kennedy Omondi Okeyo, Taiji Adachi

Publikováno v: APL Bioengineering, Vol 3, Iss 1, Pp 016102-016102-8 (2019)

The cell adhesion microenvironment plays contributory roles in the induction of self-organized tissue formation and differentiation of pluripotent stem cells (PSCs). However, physical factors emanating from the adhesion microenvironment have been les

Externí odkaz: https://doaj.org/article/bc09ec6fcab14f658ce02bbd436146eb

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Pluripotency state of mouse ES cells determines their contribution to self-organized layer formation by mesh closure on microstructured adhesion-limiting substrates

Autor: Yuta Ando, Kennedy Omondi Okeyo, Taiji Adachi

Publikováno v: Biochemical and Biophysical Research Communications. 590:97-102

Assembly of pluripotent stem cells to initiate self-organized tissue formation on engineered scaffolds is an important process in stem cell engineering. Pluripotent stem cells are known to exist in diverse pluripotency states, with heterogeneous subp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbacc4281872c481a8fab02f795f6c3
https://doi.org/10.1016/j.bbrc.2021.12.066

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