Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Yusuke Sugasawa"'
Autor:
Yusuke Sugasawa, Wayland WL Cheng, John R Bracamontes, Zi-Wei Chen, Lei Wang, Allison L Germann, Spencer R Pierce, Thomas C Senneff, Kathiresan Krishnan, David E Reichert, Douglas F Covey, Gustav Akk, Alex S Evers
Publikováno v:
eLife, Vol 9 (2020)
This study examines how site-specific binding to three identified neurosteroid-binding sites in the α1β3 GABAA receptor (GABAAR) contributes to neurosteroid allosteric modulation. We found that the potentiating neurosteroid, allopregnanolone, but n
Externí odkaz:
https://doaj.org/article/28aa0ecba7e8446f9f22fbe67ffe09fd
Autor:
Yamamoto, Makiko ⁎, Hayashida, Masakazu ⁎, 1, Kakemizu-Watanabe, Maho ⁎, Ando, Nozomi ⁎, Mukaida, Hiroshi †, Kawagoe, Izumi ⁎, Yusuke, Sugasawa ⁎, Inada, Eiichi ⁎
Publikováno v:
In Journal of Cardiothoracic and Vascular Anesthesia February 2018 32(1):187-196
Autor:
Hijai R. Shin, Y. Rose Citron, Lei Wang, Laura Tribouillard, Claire S. Goul, Robin Stipp, Yusuke Sugasawa, Aakriti Jain, Nolwenn Samson, Chun-Yan Lim, Oliver B. Davis, David Castaneda-Carpio, Mingxing Qian, Daniel K. Nomura, Rushika M. Perera, Eunyong Park, Douglas F. Covey, Mathieu Laplante, Alex S. Evers, Roberto Zoncu
Publikováno v:
Science (New York, N.Y.), vol 377, iss 6612
Science
Science
Lysosomes coordinate cellular metabolism and growth upon sensing of essential nutrients, including cholesterol. Through bioinformatic analysis of lysosomal proteomes, we identified lysosomal cholesterol signaling (LYCHOS, previously annotated as G pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5679d35b76dd78baa098dc74865d1898
https://escholarship.org/uc/item/8g07j454
https://escholarship.org/uc/item/8g07j454
Autor:
Kathiresan Krishnan, Zi-Wei Chen, Lei Wang, David E. Reichert, Daniel S. Ory, McKenna Feltes, Alex S. Evers, Jean E. Schaffer, Yusuke Sugasawa, Douglas F. Covey, Mingxing Qian, Sarah E. Gale
Publikováno v:
ACS Chem Biol
Aliphatic diazirine analogues of cholesterol have been used previously to elaborate the cholesterol proteome and identify cholesterol binding sites on proteins. Cholesterol analogues containing the trifluoromethylphenyl diazirine (TPD) group have not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a69d3b7995c8bcb0e4f0032df5bd6c
https://doi.org/10.1021/acschembio.1c00364
https://doi.org/10.1021/acschembio.1c00364
Autor:
Sakura Nakauchi, Nozomi Ando, Kinya Nishimura, Yusuke Sugasawa, Masami Miura, Masataka Fukuda, Ritsuko Inoue
Publikováno v:
European Journal of Neuroscience. 50:3520-3530
Sevoflurane, a commonly used anesthetic in surgery, has drawn attention because of its preconditioning effects in hypoxic conditions. To investigate the preconditioning effects in the striatum, a common site for ischemic stroke, we collected whole-ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3767f1fc5e7a5aa168ec68b70c75633b
https://doi.org/10.1111/ejn.14524
https://doi.org/10.1111/ejn.14524
Autor:
Laurel Mydock-McGrane, Yusuke Sugasawa, Melissa M Budelier, Wayland W.L. Cheng, John Bracamontes, Zi-Wei Chen, Alex S. Evers, Kathiresan Krishnan, Douglas F. Covey
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1864:128-136
Cholesterol is an essential component of cell membranes, and is required for mammalian pentameric ligand-gated ion channel (pLGIC) function. Computational studies suggest direct interactions between cholesterol and pLGIC’s but experimental evidence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c6437e775af277534889e668e3b46c
https://doi.org/10.1016/j.bbalip.2018.11.005
https://doi.org/10.1016/j.bbalip.2018.11.005
Autor:
Allison L, Germann, Spencer R, Pierce, Hiroki, Tateiwa, Yusuke, Sugasawa, David E, Reichert, Alex S, Evers, Joe Henry, Steinbach, Gustav, Akk
Publikováno v:
Mol Pharmacol
Prior work employing functional analysis, photolabeling, and X-ray crystallography have identified three distinct binding sites for potentiating steroids in the heteromeric GABA(A) receptor. The sites are located in the membrane-spanning domains of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16f1a21ab66b181274658ce168898929
https://pubmed.ncbi.nlm.nih.gov/33958479
https://pubmed.ncbi.nlm.nih.gov/33958479
Autor:
Lei Wang, Douglas F. Covey, Thomas C. Senneff, Gustav Akk, David E. Reichert, Allison L. Germann, Zi-Wei Chen, Wayland W.L. Cheng, John Bracamontes, Kathiresan Krishnan, Yusuke Sugasawa, Spencer R. Pierce, Alex S. Evers
Publikováno v:
eLife, Vol 9 (2020)
This study examines how site-specific binding to the three identified neurosteroid binding sites in the α1β3 GABAA receptor (GABAAR) contributes to neurosteroid allosteric modulation. We found that the potentiating neurosteroid, allopregnanolone, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeef6df0dea79b6cd5b669787c713db7
https://doi.org/10.7554/elife.55331
https://doi.org/10.7554/elife.55331
Autor:
David E. Reichert, Allison L. Germann, Zi-Wei Chen, Spencer R. Pierce, Lei Wang, Kathiresan Krishnan, Wayland Wl Cheng, Alex S. Evers, Gustav Akk, Douglas F. Covey, Thomas C. Senneff, John Bracamontes, Yusuke Sugasawa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::819536bb576e7ba1f50e2bb7d7470759
https://doi.org/10.7554/elife.55331.sa2
https://doi.org/10.7554/elife.55331.sa2
Autor:
Nozomi Ando, Ritsuko Inoue, Yusuke Sugasawa, Masami Miura, Masataka Fukuda, Sakura Nakauchi, Kinya Nishimura
Publikováno v:
Neuroscience Research. 132:8-16
Volatile anesthetics have been reported to inhibit hyperpolarization-activated cyclic-nucleotide gated channels underlying the hyperpolarization-activated cation current (Ih) that contributes to generation of synchronized oscillatory neural rhythms.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc69d15736a524f73ccf76cba667d07b
https://doi.org/10.1016/j.neures.2017.09.009
https://doi.org/10.1016/j.neures.2017.09.009