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Akademický článek

Intrauterine administration of peripheral blood mononuclear cells helps manage recurrent implantation failure by normalizing dysregulated gene expression including estrogen-responsive genes in mice

Autor: Yoshimi Kitawaki, Akihito Horie, Asami Ikeda, Shimpei Shitanaka, Akihiro Yanai, Tsutomu Ohara, Baku Nakakita, Yusuke Sagae, Asuka Okunomiya, Hirohiko Tani, Masaki Mandai

Publikováno v: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-17 (2024)

Abstract Background Intrauterine peripheral blood mononuclear cell (PBMC) therapy for recurrent implantation failure (RIF) has been reported to improve embryo implantation by acting on the endometrium. However, the exact mode of action of PBMC on the

Externí odkaz: https://doaj.org/article/072358a08d2b4fa8a5950a218ef3d995

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Plant-Specific Domains and Fragmented Sequences Imply Non-Canonical Functions in Plant Aminoacyl-tRNA Synthetases

Autor: Shiho Sakai, Yohei Toyoda, Takeshi Nakano, Yusuke Saga, Tetsuo Kushiro, Naoto Kawakami, Moeka Takahashi, Misato Kaneko, Natsuko Sato, Moeka Kawashima, Kaori Yamazaki, Shohei Takase

Publikováno v: Genes, Vol 11, Iss 1056, p 1056 (2020)
Genes
Volume 11
Issue 9

Aminoacyl-tRNA synthetases (aaRSs) play essential roles in protein translation. In addition, numerous aaRSs (mostly in vertebrates) have also been discovered to possess a range of non-canonical functions. Very few studies have been conducted to eluci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5cf5fc15c3343bd542665fbf5057b5c
https://www.mdpi.com/2073-4425/11/9/1056

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RNA-dependent synthesis of ergosteryl-3β-O-glycine in Ascomycota expands the diversity of steryl-amino acids

Autor: Nathaniel Yakobov, Nassira Mahmoudi, Guillaume Grob, Daisuke Yokokawa, Yusuke Saga, Tetsuo Kushiro, Danielle Worrell, Hervé Roy, Hubert Schaller, Bruno Senger, Laurence Huck, Gisela Riera Gascon, Hubert D. Becker, Frédéric Fischer

Publikováno v: Journal of Biological Chemistry. 298:101657

A wide range of bacteria possess virulence factors such as aminoacyl-tRNA transferases (ATTs) that are capable of rerouting aminoacyl-transfer RNAs away from protein synthesis to conjugate amino acids onto glycerolipids. We recently showed that, alth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c1f4f3f07942c01f41423b262e430a
https://doi.org/10.1016/j.jbc.2022.101657

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Effects of organ motion on proton prostate treatments, as determined from analysis of daily CT imaging for patient positioning

Autor: Makoto Sasaki, Kazutaka Yamamoto, Yuji Tameshige, Kyo Kume, Hiroki Minami, Satoshi Shibata, Sayuri Bou, Shigeyuki Takamatsu, Nobukazu Fuwa, Yoshikazu Maeda, Yoshitaka Sato, Yusuke Saga, Hiroyasu Tamamura, Makoto Saito

Publikováno v: Medical Physics. 45:1844-1856

PURPOSE We quantified interfractional movements of the prostate, seminal vesicles (SVs), and rectum during computed tomography (CT) image-guided proton therapy for prostate cancer and studied the range variation in opposed lateral proton beams. MATER

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b898381312e70956c682e570b497f02
https://doi.org/10.1002/mp.12869

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Akademický článek

Large uterine arteriovenous malformation successfully treated with combined endovascular treatment and supracervical hysterectomy: A case report

Autor: Fumika Hamaguchi, Yasuyuki Onishi, Yusuke Sagae, Koji Yamanoi, Hironori Shimizu, Masaki Mandai

Publikováno v: Case Reports in Women's Health, Vol 42, Iss , Pp e00630- (2024)

Uterine arteriovenous malformations (AVMs) are rare conditions that cause life-threatening bleeding. Endovascular treatment or total hysterectomy is performed to safely treat most AVMs. This case report describes a 54-year-old female patient with a l

Externí odkaz: https://doaj.org/article/86da19ffc25f43abb5dc100851e17404

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Development of the breast immobilization system in prone setup: The effect of bra in prone position to improve the breast setup error

Autor: Yoshitaka Sato, Hiroyasu Tamamura, Makoto Sasaki, Kouji Ohta, Yoshikazu Maeda, Mariko Kawamura, Yusuke Saga, Kazutaka Yamamoto, Yoshiyuki Itoh, Yuji Tameshige, Shinji Naganawa, Kyo Kume, Shigeyuki Takamatsu, Hiroki Minami

Publikováno v: Journal of Applied Clinical Medical Physics

Purpose/objective(s) Accurate and reproducible positioning of the breast is difficult due to its deformability and softness; thus, targeting a breast tumor or tumor bed with fractionated radiotherapy using external beam radiation is difficult. The ai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619c1671e115fd0150634d50566e86d1
https://doi.org/10.1002/acm2.12116

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Identification of Serratane Synthase Gene from the Fern Lycopodium clavatum

Autor: Hiroshi Araya, Kazuki Saito, Hideyuki Suzuki, Yusuke Saga, Takeshi Araki, Tetsuo Kushiro, Mami Yamazaki

Publikováno v: Organic Letters. 19:496-499

Ferns are known to produce onoceroids including onoceranes and serratanes having unusual structures among triterpenes. From the fern Lycopodium clavatum, a novel onoceroid synthase gene was cloned that showed high sequence identity with a previously

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b605d5ea356c4089ff4e96f81bd999d
https://doi.org/10.1021/acs.orglett.6b03659

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Allylic hydroxylation of triterpenoids by a plant cytochrome P450 triggers key chemical transformations that produce a variety of bitter compounds

Autor: Sayaka Shinpo, Yusuke Saga, Tsutomu Hosouchi, Masaaki Kotera, Junnosuke Otaka, Kazuto Mannen, Shohei Takase, Kota Kera, Hideyuki Suzuki, Hiroshi Araya, Hiroki Yamada, Yoshiki Nagashima, Tetsuo Kushiro, Moeka Kawashima, Yuki Kotake

Publikováno v: J Biol Chem

Cucurbitacins are highly oxygenated triterpenoids characteristic of plants in the family Cucurbitaceae and responsible for the bitter taste of these plants. Fruits of bitter melon (Momordica charantia) contain various cucurbitacins possessing an unus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcdf9893a92b174931bcff9db0dde76b
https://pubmed.ncbi.nlm.nih.gov/31656227

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Chain-Shortened Myostatin Inhibitory Peptides Improve Grip Strength in Mice

Autor: Kei Nirasawa, Mariko Saitoh, Yoichi Negishi, Eri Sasaki, Atsuhiko Taniguchi, Tomo Asari, Yoshio Hayashi, Yoshimi Roppongi, Kentaro Takayama, Hiroaki Ikeyama, Takahiro Shimada, Akari Nakamura, Akihiro Taguchi, Yusuke Saga

Publikováno v: ACS Med Chem Lett

[Image: see text] Inhibition of myostatin is a promising strategy for treatment of muscle atrophic disorders. We had already identified a 23-mer peptide (1) as a synthetic myostatin inhibitor, and structure–activity relationship studies with 1 affo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b9c6135876979bb8bcd473cb690ba9
https://pubmed.ncbi.nlm.nih.gov/31223459

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Synthesis of aminoacylated ergosterols: A new lipid component of fungi

Autor: Ryoka Takagi, Daisuke Yokokawa, Shunsuke Tatematsu, Yusuke Saga, Hervé Roy, Frédéric Fischer, Tetsuo Kushiro, Hubert Dominique Becker

Publikováno v: Steroids. 169:108823

Aminoacylated ergosterol such as 1-ergosteryl aspartate (Erg-Asp) is a new lipid component recently discovered in fungi. In order to study physiological functions of this novel sterol derivative and to develop potential antifungal agents, we establis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f637e8fbd304086947d509c67d262fed
https://doi.org/10.1016/j.steroids.2021.108823

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