Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Yusuke Sabu"'
Autor:
Ryutaro Tamura, Yusuke Sabu, Tadahaya Mizuno, Seiya Mizuno, Satoshi Nakano, Mitsuyoshi Suzuki, Daiki Abukawa, Shunsaku Kaji, Yoshihiro Azuma, Ayano Inui, Tatsuya Okamoto, Seiichi Shimizu, Akinari Fukuda, Seisuke Sakamoto, Mureo Kasahara, Satoru Takahashi, Hiroyuki Kusuhara, Yoh Zen, Tomohiro Ando, Hisamitsu Hayashi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Choline is an essential nutrient, and its deficiency causes steatohepatitis. Dietary phosphatidylcholine (PC) is digested into lysoPC (LPC), glycerophosphocholine, and choline in the intestinal lumen and is the primary source of systemic cho
Externí odkaz:
https://doaj.org/article/6e3497d067f34e50bfe570fb76233f5d
Autor:
Hiroyuki Kusuhara, Mitsuyoshi Suzuki, Yoshiki Miura, Shuhei Osaka, Yusuke Sabu, Hisamitsu Hayashi, Ayumu Mizutani, Satoshi Nakano, Kei Minowa, Yuka Hiraoka, Tadahaya Mizuno, Saeko Hirai, Toshiaki Shimizu
Publikováno v:
Molecular Genetics and Metabolism. 132:220-226
Urea cycle disorders (UCDs), inborn errors of hepatocyte metabolism, result in the systemic accumulation of ammonia to toxic levels. Sodium 4-phenylbutyrate (NaPB), a standard therapy for UCDs for over 20 years, generates an alternative pathway of ni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04653bd512aa0f39372d07d505462602
https://doi.org/10.1016/j.ymgme.2021.02.002
https://doi.org/10.1016/j.ymgme.2021.02.002
Autor:
Eitaro Aihara, Ayumu Mizutani, Nakayuki Naritaka, Hiroyuki Kusuhara, Yusuke Sabu, Aiko Fukami, Kenneth D. R. Setchell, Christopher N. Mayhew, Takanori Takebe, Akihiro Asai, Shuhei Osaka, Hisamitsu Hayashi, Masahide Sakabe, Kokoro Sakabe, Takahisa Nakamura, Eriko Kishimoto, Yueh Chiang Hu, Wujuan Zhang, Stacey S. Huppert
Publikováno v:
Stem Cell Reports
Summary The bile salt export pump (BSEP) is responsible for the export of bile acid from hepatocytes. Impaired transcellular transport of bile acids in hepatocytes with mutations in BSEP causes cholestasis. Compensatory mechanisms to regulate the int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70ab469ffecf140b481001d135e4c59
https://doi.org/10.1016/j.stemcr.2020.12.008
https://doi.org/10.1016/j.stemcr.2020.12.008
Autor:
Tatsuki Mizuochi, Satoshi Watanabe, Yusuke Sabu, Hiroyuki Kusuhara, Kazuhiko Bessho, Koichi Ito, Daiki Abukawa, Mika Sasaki, Yukihiro Inomata, Ayano Inui, M Kasahara, Akinari Fukuda, Hisamitsu Hayashi, Kei Minowa, Sotaro Naoi, Koji Muroya, Ayumu Mizutani, Yuki Oya, Yoshihiro Azuma, Mitsuyoshi Suzuki, Shogo Ito, Hajime Takikawa, Satoshi Nakano, Shunsaku Kaji, Takao Togawa
Publikováno v:
Hepatology Communications
Adenosine triphosphatase phospholipid transporting 8B1 (ATP8B1) deficiency, an ultrarare autosomal recessive liver disease, includes severe and mild clinical forms, referred to as progressive familial intrahepatic cholestasis type 1 (PFIC1) and benig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e60a8a6c0556cfb64b27c426964ad61
https://pubmed.ncbi.nlm.nih.gov/33437900
https://pubmed.ncbi.nlm.nih.gov/33437900
Autor:
Kazuhiko Bessho, Hiroyuki Kusuhara, Atsuko Nakazawa, Hironori Kusano, Ayano Inui, Saeko Hirai, Satoshi Nakano, Hisamitsu Hayashi, Kei Minowa, Satoshi Watanabe, Masayoshi Kage, Yusuke Sabu, Yoh Zen, Yoshihiro Azuma, Toshiaki Shimizu, Shuhei Osaka, Hiroki Kondou, Ken Tanikawa, Hidefumi Nakamura, Takeshi Kimura, Mitsuyoshi Suzuki
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Progressive familial intrahepatic cholestasis (PFIC), a rare inherited disorder, progresses to liver failure in childhood. We have shown that sodium 4-phenylbutyrate (NaPB), a drug approved for urea cycle disorders (UCDs), has beneficial effects in P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cbb66f87b204c203ff08be77f352c7a
http://europepmc.org/articles/PMC6863819
http://europepmc.org/articles/PMC6863819
Autor:
Atsuko Nakazawa, Hironori Kusano, Yoshihiro Azuma, Shuhei Osaka, Hidefumi Nakamura, Hiroyuki Kusuhara, Toshiaki Shimizu, Ken Tanikawa, Hisamitsu Hayashi, Kei Minowa, Takeshi Kimura, Yusuke Sabu, Kazuhiko Bessho, Mitsuyoshi Suzuki, Hiroki Kondou, Satoshi Nakano, Satoshi Watanabe, Yoh Zen, Masayoshi Kage, Saeko Hirai, Ayano Inui
Publikováno v:
SSRN Electronic Journal.
Progressive familial intrahepatic cholestasis (PFIC), a rare inherited recessive liver disease, progresses to liver failure in childhood. There is no effective medical therapy for PFIC. We and other groups have shown that sodium 4-phenylbutyrate (NaP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16fb70b4413fa0ec37dc1235b4da921a
https://doi.org/10.2139/ssrn.3321476
https://doi.org/10.2139/ssrn.3321476
Autor:
Masayoshi Kage, Hisamitsu Hayashi, Daigo Kajikawa, Jun Fujishiro, Hiroyuki Kusuhara, Ryo Sumazaki, Hiroki Wada, Yusuke Sabu, Kazuo Imagawa, Ken Tanikawa, Toyoichiro Kudo
Publikováno v:
Journal of human genetics. 63(5)
The bile salt export pump (BSEP) plays an important role in biliary secretion. Mutations in ABCB11, the gene encoding BSEP, induce progressive familial intrahepatic cholestasis type 2 (PFIC2), which presents with severe jaundice and liver dysfunction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be4742fe7ca2d1bd6288e441ad894942
https://pubmed.ncbi.nlm.nih.gov/29507376
https://pubmed.ncbi.nlm.nih.gov/29507376