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Akademický článek

Development of the iLiNP Device: Fine Tuning the Lipid Nanoparticle Size within 10 nm for Drug Delivery

Autor: Niko Kimura, Masatoshi Maeki, Yusuke Sato, Yusuke Note, Akihiko Ishida, Hirofumi Tani, Hideyoshi Harashima, Manabu Tokeshi

Publikováno v: ACS Omega, Vol 3, Iss 5, Pp 5044-5051 (2018)

Externí odkaz: https://doaj.org/article/a82498df191c4ee099998e3aae4238eb

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Hydrophobic scaffolds of pH-sensitive cationic lipids contribute to miscibility with phospholipids and improve the efficiency of delivering short interfering RNA by small-sized lipid nanoparticles

Autor: Yusuke Sato, Nana Okabe, Yusuke Note, Kazuki Hashiba, Masatoshi Maeki, Manabu Tokeshi, Hideyoshi Harashima

Publikováno v: Acta biomaterialia. 102

Despite the fact that small-sized lipid nanoparticles (LNPs) are important for improved tissue penetration and efficient drug delivery, their poor stability and intracellular trafficking significantly hinders their use as potent small-sized LNPs. It

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fe1de56ac96dd236b9cba31756fb933
https://pubmed.ncbi.nlm.nih.gov/31733331

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Elucidation of the physicochemical properties and potency of siRNA-loaded small-sized lipid nanoparticles for siRNA delivery

Autor: Yusuke Sato, Yusuke Note, Masatoshi Maeki, Noritada Kaji, Yoshinobu Baba, Manabu Tokeshi, Hideyoshi Harashima

Publikováno v: Journal of controlled release. 229:48-57

Because nanoparticles with diameters less than 50 nm penetrate stromal-rich tumor tissues more efficiently, the synthesis of small-sized nanoparticles encapsulating short interfering RNA (siRNA) is important in terms of realizing novel siRNA medicine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b473eb64ca5edacc114e4a8b14fe7bb5
http://hdl.handle.net/2115/65236

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