Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Yusuke Nakatsu"'
Epicatechin suppresses the expression of C-C motif chemokine ligand 19 and ameliorates periodontitis
Autor:
Tomomi Sano, Meiqun Yuan, Rongzhi Li, Atsushi Yasunaga, Akiko Mizokami, Yusuke Nakatsu, Tomoichiro Asano, Takashi Kanematsu
Publikováno v:
Journal of Functional Foods, Vol 122, Iss , Pp 106512- (2024)
Periodontitis is a prevalent chronic inflammatory disease requiring the development of drug-based therapies. Epicatechin is a major polyphenol in cocoa extract and possesses numerous pharmacological properties. This study aimed to investigate the sup
Externí odkaz:
https://doaj.org/article/f3cf4e6be97f45bba877c97b7928c7d6
Autor:
Miki Naito, Kenichiro Ikeda, Shunya Aoyama, Mayu Kanamoto, Yasuyuki Akasaka, Yuri Kido, Mikako Nakanishi, Machi Kanna, Takeshi Yamamotoya, Akio Matsubara, Nobuyuki Hinata, Tomoichiro Asano, Yusuke Nakatsu
Publikováno v:
Cancer Medicine, Vol 12, Iss 7, Pp 8464-8475 (2023)
Abstract Background Prostate cancer (PCa) is a major cause of cancer morbidity and mortality for men globally, and androgen signaling clearly drives its onset and progression. Androgen receptor (AR) regulation is complex and remains elusive, despite
Externí odkaz:
https://doaj.org/article/d7964372336c4c389b0a4a53556d9cd9
Autor:
Yasuyuki Akasaka, Shun Hasei, Yukino Ohata, Machi Kanna, Yusuke Nakatsu, Hideyuki Sakoda, Midori Fujishiro, Akifumi Kushiyama, Hiraku Ono, Akio Matsubara, Nobuyuki Hinata, Tomoichiro Asano, Takeshi Yamamotoya
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 16011 (2023)
Citrus hassaku extract reportedly activates AMPK. Because this extract contains an abundance of auraptene, we investigated whether pure auraptene activates AMPK and inhibits proliferation using prostate cancer cell lines. Indeed, auraptene inhibited
Externí odkaz:
https://doaj.org/article/44ff9359f15b4ceea2ed36afec31aca0
Autor:
Takeshi Yamamotoya, Shun Hasei, Yasuyuki Akasaka, Yukino Ohata, Yusuke Nakatsu, Machi Kanna, Midori Fujishiro, Hideyuki Sakoda, Hiraku Ono, Akifumi Kushiyama, Hidemi Misawa, Tomoichiro Asano
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Trk-fused gene (TFG) mutations have been identified in patients with several neurodegenerative diseases. In this study, we attempted to clarify the effects of TFG deletions in motor neurons and in muscle fibers, using tissue-specific TFG kno
Externí odkaz:
https://doaj.org/article/f109f4bc83874bae9ec77110833579f6
Autor:
Takeshi Yamamotoya, Yusuke Nakatsu, Machi Kanna, Shun Hasei, Yukino Ohata, Jeffrey Encinas, Hisanaka Ito, Takayoshi Okabe, Tomoichiro Asano, Takemasa Sakaguchi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Novel coronavirus disease 2019 (COVID-19) has emerged as a global pandemic with far-reaching societal impact. Here we demonstrate that Pin1 is a key cellular molecule necessary for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Externí odkaz:
https://doaj.org/article/1ea816cff4094d0dadc3628615db9c97
Autor:
Machi Kanna, Yusuke Nakatsu, Takeshi Yamamotoya, Jeffrey Encinas, Hisanaka Ito, Takayoshi Okabe, Tomoichiro Asano, Takemasa Sakaguchi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Peptidyl-prolyl isomerase (PPIase) is a unique enzyme that promotes cis-trans isomerization of a proline residue of a target protein. Peptidyl-prolyl cis-trans isomerase NIMA (never in mitosis A)-interacting 1 (Pin1) is a PPIase that binds to the pSe
Externí odkaz:
https://doaj.org/article/3e25cfdf388544f7850861bfbd24498d
Autor:
Machi Kanna, Yusuke Nakatsu, Takeshi Yamamotoya, Akifumi Kushiyama, Midori Fujishiro, Hideyuki Sakoda, Hiraku Ono, Koji Arihiro, Tomoichiro Asano
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8847 (2023)
Our previous studies using rodent models have suggested an essential role for Pin1 in the pathogenesis of non-alcoholic steatohepatitis (NASH). In addition, interestingly, serum Pin1 elevation has been reported in NASH patients. However, no studies h
Externí odkaz:
https://doaj.org/article/12486db0ff1a4aaeb1e4e79985807409
Autor:
Masa-Ki Inoue, Yasuka Matsunaga, Yusuke Nakatsu, Takeshi Yamamotoya, Koji Ueda, Akifumi Kushiyama, Hideyuki Sakoda, Midori Fujishiro, Hiraku Ono, Misaki Iwashita, Tomomi Sano, Fusanori Nishimura, Kenichi Morii, Kensuke Sasaki, Takao Masaki, Tomoichiro Asano
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 11, Iss 1, Pp 1-11 (2019)
Abstract Background Recently, clinical studies have shown the protective effects of sodium glucose co-transporter2 (SGLT2) inhibitors against progression of diabetic nephropathy, but the underlying molecular mechanisms remain unclear. Methods Diabeti
Externí odkaz:
https://doaj.org/article/edc74bd8d48b4a0db299cb038e0d9226
Autor:
Midori Fujishiro, Hisamitsu Ishihara, Katsuhiko Ogawa, Takayo Murase, Takashi Nakamura, Kentaro Watanabe, Hideyuki Sakoda, Hiraku Ono, Takeshi Yamamotoya, Yusuke Nakatsu, Tomoichiro Asano, Akifumi Kushiyama
Publikováno v:
Biomedicines, Vol 9, Iss 8, p 1052 (2021)
To unravel associations between plasma xanthine oxidoreductase (XOR) and diabetic vascular complications, especially distal symmetric polyneuropathy (DSP), we investigated plasma XOR activities using a novel assay. Patients with type 2 diabetes melli
Externí odkaz:
https://doaj.org/article/0214beb415ce4845990878503464d78e
Autor:
Yasuka Matsunaga, Shun Hasei, Takeshi Yamamotoya, Hiroaki Honda, Akifumi Kushiyama, Hideyuki Sakoda, Midori Fujishiro, Hiraku Ono, Hisanaka Ito, Takayoshi Okabe, Tomoichiro Asano, Yusuke Nakatsu
Publikováno v:
Cells, Vol 10, Iss 5, p 1230 (2021)
Inflammatory bowel diseases (IBDs) are serious disorders of which the etiologies are not, as yet, fully understood. In this study, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) protein was shown to be dramatically upregulated in the c
Externí odkaz:
https://doaj.org/article/235732759119421e8314cf7b0dc6f10d