Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Yusuke Hirata"'
Autor:
Shuhei Hamano, Takuya Noguchi, Yukino Asai, Ryo Ito, Ryuto Komatsu, Tetsu Sato, Aya Inoue, Tomoe Maruyama, Tada-aki Kudo, Yusuke Hirata, Sawako Shindo, Yasuo Uchida, Gi-Wook Hwang, Atsushi Matsuzawa
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Overactivation of poly (ADP-ribose) polymerase-1 (PARP-1) triggers a noncanonical form of programmed cell death (PCD) called parthanatos, yet the mechanisms of its induction are not fully understood. We have recently demonstrated that the ag
Externí odkaz:
https://doaj.org/article/b7f5edef378747cea8f183b47365b8da
Autor:
Takumi Yokosawa, Sayoko Miyagawa, Wakana Suzuki, Yuki Nada, Yusuke Hirata, Takuya Noguchi, Atsushi Matsuzawa
Publikováno v:
Cells, Vol 13, Iss 8, p 687 (2024)
Toll-like receptors (TLRs) induce innate immune responses through activation of intracellular signaling pathways, such as MAP kinase and NF-κB signaling pathways, and play an important role in host defense against bacterial or viral infections. Mean
Externí odkaz:
https://doaj.org/article/daadd732fe4540948f36ff0e765d687e
Autor:
Yusuke Hirata, Naoki Kashiwabara, Yuki Nada, Aya Inoue, Emiko Sato, Takuya Noguchi, Atsushi Matsuzawa
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract trans-Fatty acids (TFAs) are unsaturated fatty acids containing at least one carbon–carbon double bond in trans configuration, which are classified into two groups according to their food source: industrial TFAs (iTFAs) and ruminant TFAs (
Externí odkaz:
https://doaj.org/article/ca2bdae0ca8944b59ea43e486db866cc
Autor:
Yuriko Mikami-Saitoh, Hiroyuki Kyoyama, Yusuke Hirata, Satoshi Kikuchi, Kosuke Sakai, Shintaro Mikami, Gaku Moriyama, Nobuyuki Koyama, Morihiro Higashi, Akihiro Ishizu, Kazutsugu Uematsu
Publikováno v:
Respiratory Medicine Case Reports, Vol 46, Iss , Pp 101951- (2023)
A 72-year-old female presented with bilateral pulmonary nodules before undergoing surgery for hysteroptosis. Transbronchial biopsy did not lead to a definitive diagnosis. The right mass in the upper lobe was resected through video-assisted thoracic s
Externí odkaz:
https://doaj.org/article/245fc8d7eeb24807bb1cc9f921fe56de
Autor:
Yusuke Hirata, Miki Takahashi, Yuto Yamada, Ryosuke Matsui, Aya Inoue, Ryo Ashida, Takuya Noguchi, Atsushi Matsuzawa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract trans-Fatty acids (TFAs) are food-derived fatty acids associated with various diseases including cardiovascular diseases. However, the underlying etiology is poorly understood. Here, we show a pro-apoptotic mechanism of TFAs such as elaidic
Externí odkaz:
https://doaj.org/article/10e32ffef03445fa95dcd28b136361ce
Autor:
Kosuke Sakai, Maya Inoue, Shintaro Mikami, Hiroaki Nishimura, Yoshiki Kuwabara, Akitoshi Kojima, Maiko Toda, Yumiko Ogawa‐Kobayashi, Satoshi Kikuchi, Yusuke Hirata, Yuriko Mikami‐Saito, Hiroyuki Kyoyama, Gaku Moriyama, Michio Shiibashi, Masahiro Seike, Akihiko Gemma, Kazutsugu Uematsu
Publikováno v:
Thoracic Cancer, Vol 12, Iss 4, Pp 491-503 (2021)
Abstract Background: Pleural mesothelioma, a devastating asbestos‐associated malignancy, urgently requires a novel effective therapy. Heat shock protein 70 (HSP70), which is synthesized in the cell response to protein damage, is expected to be a ne
Externí odkaz:
https://doaj.org/article/de0ba9c4d7674cdca8e4d21b76d98a2c
Autor:
Takuya Noguchi, Yuto Sekiguchi, Yuki Kudoh, Rio Naganuma, Tomohiro Kagi, Akiko Nishidate, Kazuhiro Maeda, Chizuru Ishii, Takashi Toyama, Yusuke Hirata, Gi-Wook Hwang, Atsushi Matsuzawa
Publikováno v:
Cell Death and Disease, Vol 12, Iss 1, Pp 1-17 (2021)
Abstract Anticancer drug gefitinib causes inflammation-based side effects, such as interstitial pneumonitis. However, its mechanisms remain unknown. Here, we provide evidence that gefitinib elicits pro-inflammatory responses by promoting mature-inter
Externí odkaz:
https://doaj.org/article/8caaaf62bd0b45138093e5fa58c4ec7a
Autor:
Tatsuya Shimada, Yohsuke Yabuki, Takuya Noguchi, Mei Tsuchida, Ryuto Komatsu, Shuhei Hamano, Mayuka Yamada, Yusuke Ezaki, Yusuke Hirata, Atsushi Matsuzawa
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 10064 (2022)
Liver kinase B1 (LKB1) is a serine/threonine protein kinase that acts as a key tumor suppressor protein by activating its downstream kinases, such as AMP-activated protein kinase (AMPK). However, the regulatory actions of LKB1 and AMPK on DNA damage
Externí odkaz:
https://doaj.org/article/a3f3212c68684a388efabc831a2ccaf2
Autor:
Yusuke Hirata, Kazumi Katagiri, Keita Nagaoka, Tohru Morishita, Yuki Kudoh, Tomohisa Hatta, Isao Naguro, Kuniyuki Kano, Tsuyoshi Udagawa, Tohru Natsume, Junken Aoki, Toshifumi Inada, Takuya Noguchi, Hidenori Ichijo, Atsushi Matsuzawa
Publikováno v:
Cell Reports, Vol 21, Iss 9, Pp 2447-2457 (2017)
Apoptosis signal-regulating kinase 1 (ASK1) is an oxidative stress-responsive kinase that is regulated by various interacting molecules and post-translational modifications. However, how these molecules and modifications cooperatively regulate ASK1 a
Externí odkaz:
https://doaj.org/article/9ca37944f87e433b964657198334ee8b
Autor:
Tatsuya Shimada, Yuki Kudoh, Takuya Noguchi, Tomohiro Kagi, Midori Suzuki, Mei Tsuchida, Hiromu Komatsu, Miki Takahashi, Yusuke Hirata, Atsushi Matsuzawa
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5796 (2021)
Receptor-interacting protein kinase 1 (RIPK1) is a key component of the tumor necrosis factor (TNF) receptor signaling complex that regulates both pro- and anti-apoptotic signaling. The reciprocal functions of RIPK1 in TNF signaling are determined by
Externí odkaz:
https://doaj.org/article/56ad76cb8a5f47b3916e3221068f734c