Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Yusuke Higashi"'
Publikováno v:
Cells, Vol 13, Iss 20, p 1673 (2024)
Curcumin, a polyphenolic compound derived from the widely used spice Curcuma longa, has shown anti-atherosclerotic effects in animal models and cultured vascular cells. Inflammation is a major contributor to atherosclerosis development and progressio
Externí odkaz:
https://doaj.org/article/951da8c5e21541baabfef6ba0cd6bfda
Autor:
Santosh R. Alluri, Yusuke Higashi, Ashley Berendzen, Laurel A. Grisanti, Lisa D. Watkinson, Kamlendra Singh, Timothy J. Hoffman, Terry Carmack, Elizabeth A. Devanny, Miles Tanner, Kun-Eek Kil
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Background CXCR3 is a chemokine receptor and is expressed in innate and adaptive immune cells. It promotes the recruitment of T-lymphocytes and other immune cells to the inflammatory site in response to the binding of cognate chemokines. Upr
Externí odkaz:
https://doaj.org/article/73c5c4708f6f4cbca64b73a63ab736cb
Autor:
Sergiy Sukhanov, Yusuke Higashi, Tadashi Yoshida, Svitlana Danchuk, Mitzi Alfortish, Traci Goodchild, Amy Scarborough, Thomas Sharp, James S. Jenkins, Daniel Garcia, Jan Ivey, Darla L. Tharp, Jeffrey Schumacher, Zach Rozenbaum, Jay K. Kolls, Douglas Bowles, David Lefer, Patrice Delafontaine
Publikováno v:
JCI Insight, Vol 8, Iss 4 (2023)
Although murine models of coronary atherosclerotic disease have been used extensively to determine mechanisms, limited new therapeutic options have emerged. Pigs with familial hypercholesterolemia (FH pigs) develop complex coronary atheromas that are
Externí odkaz:
https://doaj.org/article/a47c75425ece46c49fb6cd03b148e52b
Publikováno v:
Mediators of Inflammation, Vol 2023 (2023)
Persistent oxidative stress and inflammation contribute causally to smooth muscle cell (SMC) proliferation and migration, the characteristic features of vascular proliferative diseases. Oxidatively modified low-density lipoproteins (OxLDL) elevate ox
Externí odkaz:
https://doaj.org/article/f844dea7a53349e5bf853b4405db9a28
Publikováno v:
Journal of Aging Research, Vol 2020 (2020)
Mitochondrial dysfunction is a hallmark of cellular aging. Mitophagy is a critical mitochondrial quality control mechanism that removes dysfunctional mitochondria and contributes to cell survival. Insulin-like growth factor 1 (IGF-1) promotes surviva
Externí odkaz:
https://doaj.org/article/c1d1a32b4b9c4b5fa6681e35c39a3913
Publikováno v:
Molecules, Vol 26, Iss 17, p 5174 (2021)
Chemokines and chemokine receptors have been recognized as critical signal components that maintain the physiological functions of various cells, particularly the immune cells. The signals of chemokines/chemokine receptors guide various leukocytes to
Externí odkaz:
https://doaj.org/article/c5bf4f480b6449dfaf319dd5cd769ff1
Autor:
Yasuyuki Fujimoto, Hiroyuki Itabe, Tetsuaki Kinoshita, Koichi J. Homma, Jun Onoduka, Masahiro Mori, Shinji Yamaguchi, Minoru Makita, Yusuke Higashi, Atsushi Yamashita, Tatsuya Takano
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 6, Pp 1280-1292 (2007)
Lipid droplets (LDs) function as intracellular storage depots of neutral lipids. Recently, we identified long-chain acyl-coenzyme A synthetase 3 (ACSL3) as a major LD-associated protein in the human hepatocyte cell line HuH7. In this study, we invest
Externí odkaz:
https://doaj.org/article/a3bac7b6a76b4d11b48a372929756a31
Autor:
Yusuke Higashi, Tao Peng, Jie Du, Sergiy Sukhanov, Yangxin Li, Hiroyuki Itabe, Sampath Parthasarathy, Patrick Delafontaine
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 6, Pp 1266-1277 (2005)
Oxidized low density lipoprotein (OxLDL) has multiple proatherogenic effects, including induction of apoptosis. We have recently shown that OxLDL markedly downregulates insulin-like growth factor-1 receptor (IGF-1R) in human aortic smooth muscle cell
Externí odkaz:
https://doaj.org/article/466469ecc07842a78070b66c9cfa37ab
Foam cell formation containing lipid droplets enriched with free cholesterol by hyperlipidemic serum
Autor:
Masahiro Mori, Hiroyuki Itabe, Yusuke Higashi, Yasuyuki Fujimoto, Masahiro Shiomi, Masao Yoshizumi, Yasuyoshi Ouchi, Tatsuya Takano
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 11, Pp 1771-1781 (2001)
A monoclonal antibody, ASH1a/256C (256C), which binds to atherosclerotic lesions in Watanabe heritable hyperlipidemic rabbit (WHHL) aorta in vivo, recognizes complex structures of phosphatidylcholine mixed with neutral lipids. In the present study, a
Externí odkaz:
https://doaj.org/article/469cfd6377464fad8975745cc5114740
Autor:
Bashir M Rezk, Tadashi Yoshida, Laura Semprun-Prieto, Yusuke Higashi, Sergiy Sukhanov, Patrice Delafontaine
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30276 (2012)
Advanced congestive heart failure (CHF) and chronic kidney disease (CKD) are characterized by increased angiotensin II (Ang II) levels and are often accompanied by significant skeletal muscle wasting that negatively impacts mortality and morbidity. B
Externí odkaz:
https://doaj.org/article/28de6ce6118f464f834d0345c002d700