Selective purification and characterization of adiponectin multimer species from human plasma

Autor: Kazuo Hara, Takashi Kadowaki, Osamu Miyazaki, Atsushi Tsuchida, Hironori Waki, Yusuke Hada, Hirokazu Yago, Toshimasa Yamauchi, Hiroyuki Ebinuma

Publikováno v: Biochemical and Biophysical Research Communications. 356:487-493

Adiponectin is an adipocyte-derived hormone and known to form several species of multimer, however, the precise components of each multimer have not been fully determined. We purified each multimer adiponectin selectively from human plasma and charac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f158ce5771fa036edbf85c1eba21c971
https://doi.org/10.1016/j.bbrc.2007.03.004

Peroxisome Proliferator–Activated Receptor (PPAR)α Activation Increases Adiponectin Receptors and Reduces Obesity-Related Inflammation in Adipose Tissue

Autor: Toshimasa Yamauchi, Sato Takekawa, Takashi Kadowaki, Atsushi Tsuchida, Toshiyuki Maki, Yusuke Hada, Yusuke Ito

Publikováno v: Diabetes. 54:3358-3370

We examined the effects of activation of peroxisome proliferator-activated receptor (PPAR)alpha, PPARgamma, and both of them in combination in obese diabetic KKAy mice and investigated the mechanisms by which they improve insulin sensitivity. PPARalp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::363a8dda9b5b3a10ad70aed333cb8522
https://doi.org/10.2337/diabetes.54.12.3358

[Incretin related drugs]

Autor: Yusuke, Hada, Toshimasa, Yamauchi, Takashi, Kadowaki

Publikováno v: Nihon rinsho. Japanese journal of clinical medicine. 68(10)

Incretin, GIP and GLP-1, are blood glucose lowering hormones secreted from K cells and L cells, and are rapidly degenerated by DPP-4 within a few minutes. Recently incretin related drugs, GLP-1 analogs and DPP-4 inhibitors are developed. GLP-1 analog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::524e55bc3df7d116536ca412d100ce4b
https://pubmed.ncbi.nlm.nih.gov/20954337

Improved ELISA for selective measurement of adiponectin multimers and identification of adiponectin in human cerebrospinal fluid

Autor: Toshimasa Yamauchi, Yusuke Hada, Kazuo Hara, Naoto Kubota, Takashi Kadowaki, Takashi Miida, Hiroyuki Ebinuma

Publikováno v: Clinical chemistry. 53(8)

Background: Human serum adiponectin exists in 3 multimer forms: high molecular weight (HMW), middle molecular weight, and low molecular weight (LMW), with some of the latter bound to albumin (Alb)-LMW. Some studies have suggested that adiponectin cro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e589a4f8cd123f0270715e79d356d4
https://pubmed.ncbi.nlm.nih.gov/17599956

Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions

Autor: Takeshi Takazawa, Ryozo Nagai, Hitomi Ogata, Philippe Froguel, Masato Iwabu, Tomohiro Ide, Miki Okada-Iwabu, Tetsuya Kubota, Hideki Kozono, Kazuyuki Tobe, Iseki Takamoto, Yasunori Nio, Atsushi Tsuchida, Yusuke Hada, Masaki Tsunoda, Yusuke Ito, Junji Kamon, Kazuo Hara, Masaki Kobayashi, Toshiyuki Maki, Motoharu Awazawa, Kumpei Tokuyama, Kohjiro Ueki, Katsuyoshi Kumagai, Toshimasa Yamauchi, Naoto Kubota, Kouji Murakami, Sachiko Kawamoto, Takashi Kadowaki

Publikováno v: Nature Medicine
Nature Medicine, Nature Publishing Group, 2007, 13 (3), pp.332-9. ⟨10.1038/nm1557⟩
Nature Medicine, 2007, 13 (3), pp.332-9. ⟨10.1038/nm1557⟩

Adiponectin plays a central role as an antidiabetic and antiatherogenic adipokine. AdipoR1 and AdipoR2 serve as receptors for adiponectin in vitro, and their reduction in obesity seems to be correlated with reduced adiponectin sensitivity. Here we sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd99c583fd0904be295a1cfc6232494
https://pubmed.ncbi.nlm.nih.gov/17599632