Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Yusuke, Moritoh"'
The enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals
Autor:
Yusuke Moritoh, Shin-ichi Abe, Hiroki Akiyama, Akihiro Kobayashi, Ryokichi Koyama, Ryoma Hara, Shizuo Kasai, Masanori Watanabe
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Inositol hexakisphosphate kinase (IP6K) is involved in diverse cellular signalling pathways, but the physiological roles of IP6K in vivo remain unknown in mammals. Here, the authors show that the enzymatic activity of IP6K is essential for phosphate
Externí odkaz:
https://doaj.org/article/6758204230a747738df3dd582c9c832d
Publikováno v:
Heliyon, Vol 8, Iss 2, Pp e08889- (2022)
Aims: Pyruvate dehydrogenase (PDH) catalyzes the decarboxylation of pyruvate to acetyl-CoA, which plays a key role in linking cytosolic glycolysis to mitochondria metabolism. PDH is physiologically inactivated by pyruvate dehydrogenase kinases (PDKs)
Externí odkaz:
https://doaj.org/article/42a7338c8fe24cb38aa8a54d8c4c0604
Publikováno v:
Kidney International Reports. 8:115-125
Autor:
Masako Sasaki, Ikuo Miyahisa, Sachiko Itono, Hiroaki Yashiro, Hideyuki Hiyoshi, Kazue Tsuchimori, Ken‐ichi Hamagami, Yusuke Moritoh, Masanori Watanabe, Kimio Tohyama, Minoru Sasaki, Jun‐ichi Sakamoto, Tomohiro Kawamoto
Publikováno v:
Pharmacology Research & Perspectives, Vol 7, Iss 5, Pp n/a-n/a (2019)
Abstract Enteropeptidase, localized into the duodenum brush border, is a key enzyme catalyzing the conversion of pancreatic trypsinogen proenzyme to active trypsin, thereby regulating protein digestion and energy homeostasis. We report the discovery
Externí odkaz:
https://doaj.org/article/6a80d3a9b6c84d77bac6dd6c17560898
Autor:
Hikaru Ueno, Ryo Ito, Shin-Ichi Abe, Hitomi Ogino, Minoru Maruyama, Hirohisa Miyashita, Yasufumi Miyamoto, Yusuke Moritoh, Yoshiyuki Tsujihata, Koji Takeuchi, Nobuhiro Nishigaki
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222653 (2019)
GPR40/FFAR1 is a Gq protein-coupled receptor expressed in pancreatic β cells and enteroendocrine cells, and mediates insulin and incretin secretion to regulate feeding behavior. Several GPR40 full agonists have been reported to reduce food intake in
Externí odkaz:
https://doaj.org/article/8b8c641e5d7b42ad9c100d8692af4d44
Publikováno v:
Molecular Pharmacology. 99:286-293
Full agonist-mediated activation of free fatty acid receptor 1 (FFAR1/GPR40) alleviates diabetes in rodents. Considering that diabetes is a chronic disease, assessment of treatment durability of chronic exposure to a GPR40 full agonist is pivotal for
Autor:
Akihiro Kobayashi, Yusuke Moritoh, Tomohisa Suzuki, Jun Sugama, Masanori Watanabe, Yoshimasa Ishimura, Yuko Katayama
Publikováno v:
Nephrology Dialysis Transplantation
BackgroundInhibiting enteropeptidase, a gut serine protease regulating protein digestion, suppresses food intake and ameliorates obesity and diabetes in mice. However, the effects of enteropeptidase inhibition on kidney parameters are largely unknown
Autor:
Ryo Ito, Yoshitomi Yayoi, Koji Watanabe, Teruki Hamada, Yasuhiro Hirata, Yasufumi Miyamoto, Seiji Miwatashi, Nobuyuki Takakura, Kazuaki Takami, Yoshihiko Hirozane, Naoyoshi Noguchi, Yusuke Moritoh, Mitsugi Ookawara, Hideki Furukawa, Jumpei Aida, Masanori Watanabe, Hitomi Yuko, Tsuyoshi Maekawa
Publikováno v:
Journal of Medicinal Chemistry. 63:10352-10379
GPR40/FFAR1 is a G-protein-coupled receptor expressed in pancreatic β-cells and enteroendocrine cells. GPR40 activation stimulates secretions of insulin and incretin, both of which are the pivotal regulators of glycemic control. Therefore, a GPR40 a
Autor:
Masanori Watanabe, Osamu Matsuoka, Yusuke Moritoh, Tomoya Kagawa, Harunobu Nishizaki, Akihiro Kobayashi
Publikováno v:
Diabetes
SCO-267 is a full agonist of the free fatty acid receptor 1 (GPR40), which regulates the secretion of islet and gut hormones. In this phase 1 study, we aimed to evaluate the clinical profile of single and multiple once-daily oral administration of SC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62e48f0f0bdb259a5bf3833ed0e96fc
https://europepmc.org/articles/PMC8978616/
https://europepmc.org/articles/PMC8978616/
Publikováno v:
Journal of Chromatography A. 1681:463450
Diphosphoinositol pentakisphosphate (InsP