Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Yusuke, Hirai"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Although proteins have attractive features as biopharmaceuticals, the difficulty in delivering them into the cell interior limits their applicability. Lipid nanoparticles (LNPs) are a promising class of delivery vehicles. When designing a pr
Externí odkaz:
https://doaj.org/article/5b79394d705e4bc08ba13993b49b0bac
Publikováno v:
Bioconjugate Chemistry. 33(10):1852-1859
In precision medicine, extracellular vesicles (EVs) are promising intracellular drug delivery vehicles. The development of a quantitative analysis approach will provide valuable information from the perspective of cell biology and system design for d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b73fc8b79d2e6af34cb593f5885e57c
http://hdl.handle.net/2433/276814
http://hdl.handle.net/2433/276814
Autor:
Shiroh Futaki, Yusuke Hirai, Takahiro Iwata, Kentarou Sakamoto, Jan Vincent V. Arafiles, Hisaaki Hirose, Misao Akishiba, Miki Imanishi
Publikováno v:
Angewandte Chemie. 133:19957-19965
Fc region binding peptide conjugated with attenuated cationic amphiphilic lytic peptide L17E trimer [FcB(L17E)₃] was designed for immunoglobulin G (IgG) delivery into cells. Particle-like liquid droplets were generated by mixing Alexa Fluor 488 lab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63eda2dbfb61bc0a2f24e014397da4c6
https://doi.org/10.1002/ange.202105527
https://doi.org/10.1002/ange.202105527
Autor:
Shiroh Futaki, Yusuke Hirai, Asuka Ikitoh, Junya Michibata, Tomoka Takatani-Nakase, Kentarou Sakamoto, Akiko Ide
Publikováno v:
Bioconjugate Chemistry. 32:950-957
We previously reported an approach for intracellular protein delivery by attenuating membrane-lytic activity of cationic amphiphilic peptides on cell surfaces. HAad is one such peptides that cytosolically delivers proteins of interest, including anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bce60a95efe7fad179cacb9fe35061f9
https://doi.org/10.1021/acs.bioconjchem.1c00101
https://doi.org/10.1021/acs.bioconjchem.1c00101
Autor:
Shiroh Futaki, Masashi Kuriyama, Maxwell M. Sakyiamah, Kazuhiro Sonomura, Jan Vincent V. Arafiles, Miki Imanishi, Hirokazu Tamamura, Akira Otaka, Wataru Nomura, Hisaaki Hirose, Yusuke Hirai
Publikováno v:
Angewandte Chemie International Edition. 60:11928-11936
Macropinocytosis is among ubiquitous cellular uptake mechanisms of peptide-based intracellular delivery. Due to its capability of engulfing large macromolecules, macropinocytosis shows promise as a route for the intracellular uptake of biomacromolecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7213fc2b37209cc89c85f0c6c8a3a80f
https://doi.org/10.1002/anie.202016754
https://doi.org/10.1002/anie.202016754
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Although proteins have attractive features as biopharmaceuticals, the difficulty in delivering them into the cell interior limits their applicability. Lipid nanoparticles (LNPs) are a promising class of delivery vehicles. When designing a protein del
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de0b4b9370011d767124f3196ebc0f55
https://doi.org/10.1038/s41598-021-99180-5
https://doi.org/10.1038/s41598-021-99180-5
Autor:
Naoki Morita, Yuji Kawato, Takehisa Dewa, Yoshitaka Hamashima, Yusuke Hirai, Tomohiro Asai, Ayaka Okamoto, Naoto Oku, Hiromichi Egami, Hiroyuki Koide
Publikováno v:
Journal of Controlled Release. 295:87-92
While the influence of pKa provided by amine-containing materials in siRNA delivery vectors for use in gene-silencing has been widely studied, there are little reports in which amine pKa is controlled rigorously by using bioisosteres and its effect o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d98222433ca3bcf738b46359e39ffd7e
https://doi.org/10.1016/j.jconrel.2018.12.044
https://doi.org/10.1016/j.jconrel.2018.12.044
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Scientific Reports
Scientific Reports
We demonstrated tailored plasmon-induced transparency (PIT) in a metal (Au)–insulator (SiO2)–metal (Ag) (MIM) structure, where the Fano interference between the MIM waveguide mode and the surface plasmon polariton (SPP) resonance mode induced a t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1896660cb0549429c64bc95d7b55b4a7
http://link.springer.com/article/10.1038/s41598-017-17847-4
http://link.springer.com/article/10.1038/s41598-017-17847-4
Autor:
Hisaaki Hirose, Kentarou Sakamoto, Shiroh Futaki, Yusuke Hirai, Jan Vincent V. Arafiles, Misao Akishiba, Miki Imanishi, Takahiro Iwata
Publikováno v:
Angewandte Chemie. 133:19645-19645
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97d1aca4381317540aa61dd9399ad880
https://doi.org/10.1002/ange.202108473
https://doi.org/10.1002/ange.202108473
Autor:
Miki Imanishi, Kentarou Sakamoto, Shiroh Futaki, Hisaaki Hirose, Misao Akishiba, Takahiro Iwata, Yusuke Hirai, Jan Vincent V. Arafiles
Publikováno v:
Angewandte Chemie International Edition. 60:19493-19493
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29059457f1b3f7896829c769cdbd0d57
https://doi.org/10.1002/anie.202108473
https://doi.org/10.1002/anie.202108473