Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Yusuf Talha Tamer"'
Autor:
Madhu Sudan Manna, Yusuf Talha Tamer, Ilona Gaszek, Nicole Poulides, Ayesha Ahmed, Xiaoyu Wang, Furkan C. R. Toprak, DaNae R. Woodard, Andrew Y. Koh, Noelle S. Williams, Dominika Borek, Ali Rana Atilgan, John D. Hulleman, Canan Atilgan, Uttam Tambar, Erdal Toprak
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The efficacy of the antibiotic trimethoprim, which inhibits bacterial dihydrofolate reductase (DHFR), is limited by the rapid emergence of resistant bacteria. Here, Manna et al. show that 4’-desmethyltrimethoprim inhibits DHFR and a common TMP-resi
Externí odkaz:
https://doaj.org/article/0c5515c73c4846e48b35aa04d428f118
Publikováno v:
PLoS Biology, Vol 17, Iss 5, p e3000291 (2019)
Rapid detection and phenotyping of pathogenic microbes is critical for administration of effective antibiotic therapies and for impeding the spread of antibiotic resistance. Here, we present a novel platform, rapid ultrasensitive detector (RUSD), tha
Externí odkaz:
https://doaj.org/article/014b55450c244e1d8c8a386c4c504757
Autor:
Dilay Hazal Ayhan, Yusuf Talha Tamer, Mohammed Akbar, Stacey M Bailey, Michael Wong, Seth M Daly, David E Greenberg, Erdal Toprak
Publikováno v:
PLoS Biology, Vol 14, Iss 9, p e1002552 (2016)
The lack of effective and well-tolerated therapies against antibiotic-resistant bacteria is a global public health problem leading to prolonged treatment and increased mortality. To improve the efficacy of existing antibiotic compounds, we introduce
Externí odkaz:
https://doaj.org/article/9a5ea2cf065d4affb2e18a297df26fe9
Autor:
Yusuf Talha Tamer, William P. Russ, Fatma S. Coskun, Michael Farid, Marinelle Rodrigues, Andrew Y. Koh, Erdal Toprak, Ilona K. Gaszek
Publikováno v:
Molecular Biology and Evolution
Bacteriophages and bacterial toxins are promising antibacterial agents to treat infections caused by multidrug-resistant (MDR) bacteria. In fact, bacteriophages have recently been successfully used to treat life-threatening infections caused by MDR b
Autor:
Nicole Poulides, Erdal Toprak, Madhu Sudan Manna, Uttam K. Tambar, Xiaoyu Wang, Da Nae R. Woodard, Ali Rana Atilgan, Yusuf Talha Tamer, John D. Hulleman, Noelle S. Williams, Andrew Y. Koh, Dominika Borek, Ayesha Ahmed, Canan Atilgan, Furkan C.R. Toprak, Ilona K. Gaszek
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The antibiotic trimethoprim (TMP) is used to treat a variety of Escherichia coli infections, but its efficacy is limited by the rapid emergence of TMP-resistant bacteria. Previous laboratory evolution experiments have identified resistance-conferring
Autor:
Viet Q. Chau, Yusuf Talha Tamer, Hui Peng, Erdal Toprak, Mark A. T. Blaskovich, Rebecca M. Sebastian, M. Rhia L. Stone, Marian Renwick, John D. Hulleman, Andrew Y. Koh, Wanida Phetsang, Shyamtanu Datta
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss, Pp 27-39 (2019)
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss, Pp 27-39 (2019)
The E. coli dihydrofolate reductase (DHFR) destabilizing domain (DD), which shows promise as a biologic tool and potential gene therapy approach, can be utilized to achieve spatial and temporal control of protein abundance in vivo simply by administr
Autor:
Yusuf Talha Tamer, Erdal Toprak, Fatma S. Coskun, Andrew Y. Koh, William P. Russ, Ilona K. Gaszek, Marinelle Rodrigues, Michael Farid
Bacteriophages and bacterial toxins are promising antibacterial agents to treat infections caused by multidrug resistant (MDR) bacteria. In fact, bacteriophages have recently been successfully used to treat life-threatening infections caused by MDR b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69d401e700775a946fe22f41ffc7575b
https://doi.org/10.1101/2020.10.28.332486
https://doi.org/10.1101/2020.10.28.332486
Publikováno v:
Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XX.
Antibiotic resistance is a burgeoning global public health threats of our time. Antibiotic resistance is a multifactorial and complex problem which cannot be solved by only developing stronger and better antibiotic compounds. Rapid detection and char
Autor:
Canan Atilgan, Erdal Toprak, Tugce Batur, Yusuf Talha Tamer, Haleh Abdizadeh, Ilona K. Gaszek, Kimberly A. Reynolds, Ali Rana Atilgan
Publikováno v:
Molecular Biology and Evolution, 36(7), 1533-1550. Oxford University Press
Molecular Biology and Evolution
Molecular Biology and Evolution
Evolutionary fitness landscapes of certain antibiotic target enzymes have been comprehensively mapped showing strong high order epistasis between mutations, but understanding these effects at the biochemical and molecular levels remained open. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9c552728ab1dddb1b33c85be830ce7a
https://research.rug.nl/en/publications/fd54e9fe-e26b-48d8-9cd5-fddf4e362b33
https://research.rug.nl/en/publications/fd54e9fe-e26b-48d8-9cd5-fddf4e362b33
Publikováno v:
PLoS Biology, Vol 17, Iss 5, p e3000291 (2019)
PLoS Biology
PLoS Biology
Rapid detection and phenotyping of pathogenic microbes is critical for administration of effective antibiotic therapies and for impeding the spread of antibiotic resistance. Here, we present a novel platform, rapid ultrasensitive detector (RUSD), tha