Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Yusuf I Ali"'
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Akademický článek
Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein
Autor: Xiangrong Chen, Yusuf I Ali, Charlotte EL Fisher, Raquel Arribas-Bosacoma, Mohan B Rajasekaran, Gareth Williams, Sarah Walker, Jessica R Booth, Jessica JR Hudson, S Mark Roe, Laurence H Pearl, Simon E Ward, Frances MG Pearl, Antony W Oliver
Publikováno v: eLife, Vol 10 (2021)
BLM (Bloom syndrome protein) is a RECQ-family helicase involved in the dissolution of complex DNA structures and repair intermediates. Synthetic lethality analysis implicates BLM as a promising target in a range of cancers with defects in the DNA dam
Externí odkaz: https://doaj.org/article/9ec1a9ebd4b44f678f41f09602610beb
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2
Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein
Autor: Gareth Williams, Sarah R. Walker, Simon E. Ward, Charlotte E L Fisher, Yusuf I Ali, Laurence H. Pearl, Xiangrong Chen, Jessica Hudson, S. Mark Roe, Jessica R Booth, Antony W. Oliver, Mohan B. Rajasekaran, Frances M. G. Pearl, Raquel Arribas-Bosacoma
Publikováno v: eLife, Vol 10 (2021)
Chen, X, Ali, Y I, Fisher, C E L, Arribas-Bosacoma, R, Rajasekaran, M B, Williams, G, Walker, S, Booth, J R, Hudson, J J R, Mark Roe, S, Pearl, L H, Ward, S E, Pearl, F M G & Oliver, A W 2021, ' Uncovering an allosteric mode of action for a selective inhibitor of human bloom syndrome protein ', eLIFE, vol. 10, e65339 . https://doi.org/10.7554/eLife.65339
eLife
BLM (Bloom syndrome protein) is a RECQ-family helicase involved in the dissolution of complex DNA structures and repair intermediates. Synthetic lethality analysis implicates BLM as a promising target in a range of cancers with defects in the DNA dam
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b9f5d9bb2c8248b64c99b0f679fee2
https://elifesciences.org/articles/65339
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5
Bioinformatics in translational drug discovery
Autor: Graeme Benstead-Hume, Xiangrong Chen, Yusuf I Ali, Sarah K. Wooller, Frances M. G. Pearl
Publikováno v: Bioscience Reports
Bioinformatics approaches are becoming ever more essential in translational drug discovery both in academia and within the pharmaceutical industry. Computational exploitation of the increasing volumes of data generated during all phases of drug disco
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc547de1e8b114fea9f7e7609aaa130
http://sro.sussex.ac.uk/id/eprint/77617/1/BSR20160180.full-2.pdf
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6
Planning A Supply Chain With Risk And Environmental Objectives
Autor: Ghanima Al-Sharrah, Haitham M. Lababidi, Yusuf I. Ali
The main objective of the current work is to introduce sustainability factors in optimizing the supply chain model for process industries. The supply chain models are normally based on purely economic considerations related to costs and profits. To a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ccb177bce480f185ae848204b4f8e4
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7
Abstract 3238: Design, synthesis and evaluation of a novel series of BLM helicase inhibitors
Autor: Xiangrong Chen, Frances M. G. Pearl, Yusuf I Ali, Simon E. Ward
Publikováno v: Cancer Research. 77:3238-3238
Helicases are enzymes that unwind DNA or RNA. As a result, they are described as ‘guardians of the genome’ and play roles in key processes such as DNA replication, RNA transcription, translation, DNA repair and DNA recombination. Certain helicase
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b85c61587023a58a255783cf77a883d4
https://doi.org/10.1158/1538-7445.am2017-3238
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