Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Yushu Rao"'
Publikováno v:
Pharmacogenetics. 14:615-626
Genetically variable CYP2A6 is the primary enzyme that inactivates nicotine to cotinine. Our objective was to investigate allele frequencies among five ethnic groups and to investigate the relationship between genetically slow nicotine metabolic inac
Publikováno v:
Journal of Neurochemistry. 82:1376-1387
Cytochrome P450 (CYP) 2D6 is expressed in liver, brain and other extrahepatic tissues where it metabolizes a range of centrally acting drugs and toxins. As ethanol can induce CYP2D in rat brain, we hypothesized that CYP2D6 expression is higher in bra
Autor:
Rachel F. Tyndale, Chun Xu, Yushu Rao, Edward M. Sellers, Jeffrey P. Jones, B. Xu, Ewa Hoffmann
Publikováno v:
Biochemical and Biophysical Research Communications. 290:318-324
We developed genotyping assays for CYP2A6*7 (Ile471Thr) and CYP2A6*8 (Arg485Leu). We found higher allelic frequencies in Japanese and Chinese versus Caucasians and identified an allele in which both substitutions occur together (CYP2A6*10). We create
Autor:
Rachel F. Tyndale, Mohammad I. Zia, Laurent Bodin, Yushu Rao, Marilyn V. Zeman, Edward M. Sellers, Ewa Hoffmann
Publikováno v:
Molecular Pharmacology. 58:747-755
In humans, 80% of nicotine is metabolized to the inactive metabolite cotinine by the enzyme CYP2A6, which can also activate tobacco smoke procarcinogens (e.g., 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone). Previously, we demonstrated that individu
Publikováno v:
Journal of neurochemistry. 82(6)
Cytochrome P450 (CYP) 2D6 is expressed in liver, brain and other extrahepatic tissues where it metabolizes a range of centrally acting drugs and toxins. As ethanol can induce CYP2D in rat brain, we hypothesized that CYP2D6 expression is higher in bra
Autor:
Yushu Rao, S. Wang, R. Kim, M. Zeman, E. Hoffmann, Edward M. Sellers, L. Bodin, Rachel F. Tyndale, K. Ahijevych, M. Zia
Publikováno v:
Drug and Alcohol Dependence. 60:S250-S251
Publikováno v:
Scopus-Elsevier
1. Human CYP2D6 is present in brain, metabolizes many drugs and has been implicated in Parkinson's and Alzheimer's diseases and some cancers. It is still unclear which of the six known rat CYP2D subfamily members is/are homologous to human CYP2D6. 2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daee1c7aef364ddb900195973903bf8b
http://www.scopus.com/inward/record.url?eid=2-s2.0-0033947897&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-0033947897&partnerID=MN8TOARS