Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Yury V, Kuzmichev"'
Autor:
Yury V. Kuzmichev, Carol Lackman-Smith, Sonia Bakkour, Ann Wiegand, Michael J. Bale, Andrew Musick, Wendy Bernstein, Naomi Aronson, Julie Ake, Sodsai Tovanabutra, Mars Stone, Roger G. Ptak, Mary F. Kearney, Michael P. Busch, Elizabeth R. Wonderlich, Deanna A. Kulpa
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract The advent of combined antiretroviral therapy (cART) has been instrumental in controlling HIV-1 replication and transmission and decreasing associated morbidity and mortality. However, cART alone is not able to cure HIV-1 due to the presence
Externí odkaz:
https://doaj.org/article/545480fa87244f56b8e17d09e2796b5a
Autor:
Nathan W Cummins, Jason Baker, Rana Chakraborty, Patrick G Dean, Enrique Garcia-Rivera, Ashton Krogman, Shaji Kumar, Yury V Kuzmichev, Gregory M Laird, Alan Landay, Mathias Lichterfeld, Maryam Mahmood, Jeffrey Martinson, Mark Maynes, Sekar Natesampillai, Vincent Rajkumar, Yelizaveta Rassadkina, Kristen D. Ritter, Christina G Rivera, Stacey A Rizza, Krupa Subramanian, Aaron J Tande, Elizabeth R Wonderlich, Jennifer A Whitaker, John Zeuli, Andrew D Badley
Publikováno v:
EClinicalMedicine, Vol 42, Iss , Pp 101225- (2021)
Background: Achieving a functional or sterilizing cure for HIV will require identification of therapeutic interventions that reduce HIV reservoir size in infected individuals. Proteasome inhibitors, such as ixazomib, impact multiple aspects of HIV bi
Externí odkaz:
https://doaj.org/article/9bcbc1806c0c4535bde930e29c873a95
Autor:
Carolyn A. Robinson, Terri D. Lyddon, Hwi Min Gil, David T. Evans, Yury V. Kuzmichev, Jonathan Richard, Andrés Finzi, Sarah Welbourn, Lynn Rasmussen, N. Miranda Nebane, Vandana V. Gupta, Sam Ananthan, Zhaohui Cai, Elizabeth R. Wonderlich, Corinne E. Augelli-Szafran, Robert Bostwick, Roger G. Ptak, Susan M. Schader, Marc C. Johnson
Publikováno v:
Viruses, Vol 14, Iss 4, p 817 (2022)
HIV-1 Vpu targets the host cell proteins CD4 and BST-2/Tetherin for degradation, ultimately resulting in enhanced virus spread and host immune evasion. The discovery and characterization of small molecules that antagonize Vpu would further elucidate
Externí odkaz:
https://doaj.org/article/cb9aa0928f724cc5b71172c99af2a758
Publikováno v:
Microorganisms, Vol 9, Iss 8, p 1744 (2021)
SARS-CoV-2 genetic variants are emerging around the globe. Unfortunately, several SARS-CoV-2 variants, especially variants of concern (VOCs), are less susceptible to neutralization by the convalescent and post-vaccination sera, raising concerns of in
Externí odkaz:
https://doaj.org/article/9306e129fede4dbf9ef25dae7b138d60
Autor:
Yury V. Kuzmichev, Rebecca T. Veenhuis, Christopher W. Pohlmeyer, Caroline C. Garliss, Victoria E.K. Walker-Sperling, Joel N. Blankson
Publikováno v:
Journal of Virus Eradication, Vol 3, Iss 2, Pp 85-89 (2017)
Aims: Latently infected resting CD4 T cells represent a major barrier to HIV-1 eradication efforts. The standard assays used for measuring this reservoir induce activation of resting CD4 T cells with either phytohaemagglutinin (PHA) with irradiated f
Externí odkaz:
https://doaj.org/article/78510525787849868c8a9903812c3cd6
Autor:
Lori A. Emert-Sedlak, Omar Moukha-Chafiq, Haibin Shi, Shoucheng Du, John J. Alvarado, Vibha Pathak, Samuel G. Tanner, Robert N. Hunter, Miranda Nebane, Li Chen, Tatiana V. Ilina, Rieko Ishima, Sixue Zhang, Yury V. Kuzmichev, Elizabeth R. Wonderlich, Susan M. Schader, Corinne E. Augelli-Szafran, Roger G. Ptak, Thomas E. Smithgall
Publikováno v:
ACS Infect Dis
HIV-1 Nef is an attractive target for antiretroviral drug discovery because of its roles promoting HIV-1 infectivity, replication, and host immune system avoidance. Here we applied a screening strategy in which recombinant HIV-1 Nef protein was coupl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::064dd24ecf34062d1f6d9a8ee5a6334d
https://doi.org/10.1021/acsinfecdis.1c00288
https://doi.org/10.1021/acsinfecdis.1c00288
Autor:
Aaron J. Tande, Gregory M. Laird, Sekar Natesampillai, Maryam Mahmood, Mathias Lichterfeld, Rana Chakraborty, Kristen D. Ritter, K. G. Subramanian, Yury V Kuzmichev, Stacey A. Rizza, Alan L. Landay, Christina G. Rivera, Ashton Krogman, Shaji Kumar, Andrew D. Badley, Jeffrey Martinson, Nathan W. Cummins, Mark Maynes, Elizabeth R. Wonderlich, Jennifer A Whitaker, Yelizaveta Rassadkina, Enrique Garcia-Rivera, Jason V. Baker, Vincent Rajkumar, John D. Zeuli, Patrick G. Dean
Publikováno v:
EClinicalMedicine
EClinicalMedicine, Vol 42, Iss, Pp 101225-(2021)
EClinicalMedicine, Vol 42, Iss, Pp 101225-(2021)
Background Achieving a functional or sterilizing cure for HIV will require identification of therapeutic interventions that reduce HIV reservoir size in infected individuals. Proteasome inhibitors, such as ixazomib, impact multiple aspects of HIV bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f260b6fa7553a37cd83561babf1681
http://europepmc.org/articles/PMC8639424
http://europepmc.org/articles/PMC8639424
Autor:
James M Billingsley, Premeela A Rajakumar, Michelle A Connole, Nadine C Salisch, Sama Adnan, Yury V Kuzmichev, Henoch S Hong, R Keith Reeves, Hyung-joo Kang, Wenjun Li, Qingsheng Li, Ashley T Haase, R Paul Johnson
Publikováno v:
PLoS Pathogens, Vol 11, Iss 3, p e1004740 (2015)
The onset of protective immunity against pathogenic SIV challenge in SIVΔnef-vaccinated macaques is delayed for 15-20 weeks, a process that is related to qualitative changes in CD8+ T cell responses induced by SIVΔnef. As a novel approach to charac
Externí odkaz:
https://doaj.org/article/5fbe518dbfca4582888711391c84f7e3
Autor:
N. Miranda Nebane, Yury V Kuzmichev, Elizabeth R. Wonderlich, Marc C. Johnson, Jonathan Richard, Susan M. Schader, Sarah Welbourn, Andrés Finzi, Corinne E. Augelli-Szafran, Vandana V. Gupta, Roger G. Ptak, Terri D. Lyddon, Carolyn A. Robinson, Robert Bostwick, Hwi Min Gil, Zhaohui Cai, Sam Ananthan, Lynn Rasmussen, David T. Evans
HIV-1 Vpu targets the host cell proteins CD4 and BST-2/Tetherin for degradation, ultimately resulting in enhanced virus spread and host immune evasion. The discovery and characterization of small molecules that antagonize Vpu would further elucidate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09ea728eb1d665c2ecfc789c351c71ad
https://doi.org/10.1101/2021.07.30.454560
https://doi.org/10.1101/2021.07.30.454560
Autor:
Rebecca T. Veenhuis, Caroline C. Garliss, Yury V. Kuzmichev, Victoria E. Walker-Sperling, Joel N. Blankson, Christopher W. Pohlmeyer
Publikováno v:
Journal of Virus Eradication, Vol 3, Iss 2, Pp 85-89 (2017)
Journal of Virus Eradication
Journal of Virus Eradication
Aims Latently infected resting CD4 T cells represent a major barrier to HIV-1 eradication efforts. The standard assays used for measuring this reservoir induce activation of resting CD4 T cells with either phytohaemagglutinin (PHA) with irradiated fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fdb56a4a535757102a1f94d6546d3d3
http://www.sciencedirect.com/science/article/pii/S2055664020302922
http://www.sciencedirect.com/science/article/pii/S2055664020302922