Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Yury O Chernoff"'
Autor:
He Gong, Nina V Romanova, Kim D Allen, Pavithra Chandramowlishwaran, Kavita Gokhale, Gary P Newnam, Piotr Mieczkowski, Michael Y Sherman, Yury O Chernoff
Publikováno v:
PLoS Genetics, Vol 8, Iss 4, p e1002634 (2012)
Polyglutamine expansion causes diseases in humans and other mammals. One example is Huntington's disease. Fragments of human huntingtin protein having an expanded polyglutamine stretch form aggregates and cause cytotoxicity in yeast cells bearing end
Externí odkaz:
https://doaj.org/article/6c8122be073a44bba6c5f45d4da6a25e
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9642 (2010)
The glutamine/asparagine (Q/N)-rich yeast prion protein Sup35 has a low intrinsic propensity to spontaneously self-assemble into ordered, beta-sheet-rich amyloid fibrils. In yeast cells, de novo formation of Sup35 aggregates is greatly facilitated by
Externí odkaz:
https://doaj.org/article/e60ab8d408104d8fa8a209091543c724
Autor:
Shuai Fang, Geng Chen, Yiyang Wang, Rakhee Ganti, Tatiana A. Chernova, Li Zhou, Savannah E. Jacobs, Duc Duong, Hiroaki Kiyokawa, Yury O. Chernoff, Ming Li, Natalia Shcherbik, Bo Zhao, Jun Yin
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102489- (2023)
Summary: Yeast is an essential model organism for studying protein ubiquitination pathways; however, identifying the direct substrates of E3 in the cell presents a challenge. Here, we present a protocol for using the orthogonal ubiquitin transfer (OU
Externí odkaz:
https://doaj.org/article/ad4df684ba904a39bd3bc5de29c4ca3e
Autor:
Sergey A. Fedotov, Elizaveta M. Gerasimova, Elena S. Vashukova, Vladimir S. Pakin, Roman V. Kapustin, Olga V. Pachuliya, Andrey S. Glotov, Konstantin Yu. Kulichikhin, Yury O. Chernoff, Aleksandr A. Rubel
Publikováno v:
Journal of obstetrics and women's diseases. 71:65-74
BACKGROUND: Preeclampsia is a multisystem complication of pregnancy associated with an increased risk of maternal / perinatal morbidity and mortality. In this regard, the development and following improvement of low-cost and convenient methods for di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f185e10833aca306ca3b3bd9ec7431f
https://doi.org/10.17816/jowd109365
https://doi.org/10.17816/jowd109365
Autor:
Lina M. Jay-Garcia, Joseph L. Cornell, Rebecca L. Howie, Quincy L. Faber, Abigail Salas, Tatiana A. Chernova, Yury O. Chernoff
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 10; Pages: 8660
Prions are transmissible self-perpetuating protein isoforms associated with diseases and heritable traits. Yeast prions and non-transmissible protein aggregates (mnemons) are frequently based on cross-β ordered fibrous aggregates (amyloids). The for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4863e50a8c6748349d281708ecc8692
Autor:
Maria S. Rubel, Sergey A. Fedotov, Anastasia V. Grizel, Julia V. Sopova, Oksana A. Malikova, Yury O. Chernoff, Aleksandr A. Rubel
Publikováno v:
Life, Vol 10, Iss 9, p 156 (2020)
Amyloids are highly ordered fibrous cross-β protein aggregates that are notorious primarily because of association with a variety of incurable human and animal diseases (termed amyloidoses), including Alzheimer’s disease (AD), Parkinson’s diseas
Externí odkaz:
https://doaj.org/article/7ee686f3de2240679580f4fa1eac0b66
Autor:
Daniel V, Kachkin, Kirill V, Volkov, Julia V, Sopova, Alexander G, Bobylev, Sergei A, Fedotov, Sergei G, Inge-Vechtomov, Oxana V, Galzitskaya, Yury O, Chernoff, Aleksandr A, Rubel, Anna Y, Aksenova
Publikováno v:
International journal of molecular sciences. 23(19)
RAD51 is a central protein of homologous recombination and DNA repair processes that maintains genome stability and ensures the accurate repair of double-stranded breaks (DSBs). In this work, we assessed amyloid properties of RAD51
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d603640ea4c211c46d7c44ef2d7f8ee8
https://pubmed.ncbi.nlm.nih.gov/36232958
https://pubmed.ncbi.nlm.nih.gov/36232958
Autor:
Matthew A. McDonald, Andreas S. Bommarius, Sven Holger Behrens, Aditi Sharma, Harrison B. Rose, Yury O. Chernoff
Publikováno v:
The Journal of Physical Chemistry B. 125:4955-4963
Understanding the aggregation mechanism of amyloid proteins, such as Sup35NM, is essential to understanding amyloid diseases. Significant recent work has focused on using the fluorescence of thioflavin T (ThT), which undergoes a red shift when bound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7edc9da7c8e08cfbd30dee0d2fc0619
https://doi.org/10.1021/acs.jpcb.0c11250
https://doi.org/10.1021/acs.jpcb.0c11250
Autor:
Vendula Hepnarova, Slavka Hamulakova, Jan Korabecny, Ondrej Soukup, Roman Mezencev, Ladislav Janovec, Martina Hrabinova, Veronika Ihnatova, Yury O. Chernoff, Zachery J. Deckner, Nikola Novakova, Zuzana Kudličková, Kamil Kuca, Petr Bzonek, Jana Janockova, Daniel Jun
Publikováno v:
Future Med Chem
The authors report on the synthesis and biological evaluation of new compounds whose structure combines tacrine and indole moieties. Tacrine–indole heterodimers were designed to inhibit cholinesterases and β-amyloid formation, and to cross the blo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231391952a0a73e9b4c1dac19dbb330c
https://doi.org/10.4155/fmc-2020-0184
https://doi.org/10.4155/fmc-2020-0184
Autor:
Emily P. Seto, Aspen L. Hirsch, Wayne W. Schubert, Pavithra Chandramowlishwaran, Yury O. Chernoff
Publikováno v:
Frontiers in microbiology. 13
The National Aeronautics and Space Administration (NASA) and the European Space Agency (ESA) are studying how to improve the safety of future planetary science sample return missions that would bring back materials to Earth. Backward planetary protec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72182b5088fa17b8811a672d9b0b4025
https://pubmed.ncbi.nlm.nih.gov/36016789
https://pubmed.ncbi.nlm.nih.gov/36016789