Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Yury M Morozov"'
Autor:
Yu-Yo Sun, Yury M Morozov, Dianer Yang, Yikun Li, R Scott Dunn, Pasko Rakic, Pak H Chan, Koji Abe, Diana M Lindquist, Chia-Yi Kuan
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98807 (2014)
Edaravone, a potent antioxidant, may improve thrombolytic therapy because it benefits ischemic stroke patients on its own and mitigates adverse effects of tissue plasminogen activator (tPA) in preclinical models. However, whether the combined tPA-eda
Externí odkaz:
https://doaj.org/article/46b6060a8b7243149c112cf5d943802f
Autor:
Dibyadeep Datta, Shannon N. Leslie, Yury M. Morozov, Alvaro Duque, Pasko Rakic, Christopher H. van Dyck, Angus C. Nairn, Amy F. T. Arnsten
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-15 (2020)
Abstract Background Cognitive impairment in schizophrenia, aging, and Alzheimer’s disease is associated with spine and synapse loss from the dorsolateral prefrontal cortex (dlPFC) layer III. Complement cascade signaling is critical in driving spine
Externí odkaz:
https://doaj.org/article/41ffea11f85e4da3bb94c0f905d4c13b
Autor:
Hong-Ru Chen, Xiaohui Zhang-Brotzge, Yury M. Morozov, Yuancheng Li, Siming Wang, Helen Heju Zhang, Irena S. Kuan, Elizabeth M. Fugate, Hui Mao, Yu-Yo Sun, Pasko Rakic, Diana M. Lindquist, Ton DeGrauw, Chia-Yi Kuan
Publikováno v:
JCI Insight, Vol 6, Iss 17 (2021)
The creatine transporter (CrT) maintains brain creatine (Cr) levels, but the effects of its deficiency on energetics adaptation under stress remain unclear. There are also no effective treatments for CrT deficiency, the second most common cause of X-
Externí odkaz:
https://doaj.org/article/927d1c1aefe84c5fbf121667460aa626
Autor:
Seiji Ishii, Masaaki Torii, Alexander I. Son, Meenu Rajendraprasad, Yury M. Morozov, Yuka Imamura Kawasawa, Anna C. Salzberg, Mitsuaki Fujimoto, Kristen Brennand, Akira Nakai, Valerie Mezger, Fred H. Gage, Pasko Rakic, Kazue Hashimoto-Torii
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Prenatal exposure to environmental stressors is known to impair cortical development. Here the authors show that upon exposure to stressors, the activation of Hsf1-Hsp signalling is highly variable among cells in the embryonic cortex of mice, and eit
Externí odkaz:
https://doaj.org/article/799a96f9df824be3a9794751c745b994
Autor:
Yury M. Morozov, Pasko Rakic
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 5
Pages: 4432
Volume 24
Issue 5
Pages: 4432
Mitochondrial malfunction and morphologic disorganization have been observed in brain cells as part of complex pathological changes. However, it is unclear what may be the role of mitochondria in the initiation of pathologic processes or if mitochond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f03fb21f7a6c3a499b80a631e4363da
Autor:
Xiaoyang Cheng, Mikihito Shibata, Stephen G. Waxman, Sydney Muchnik, Navjot Kaur, Yury M. Morozov, Kartik Pattabiraman, Nenad Sestan
Publikováno v:
Nature. 598:489-494
The similarities and differences between nervous systems of various species result from developmental constraints and specific adaptations1–4. Comparative analyses of the prefrontal cortex (PFC), a cerebral cortex region involved in higher-order co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::434c993e35d3b4ed42f0d5acb9ea1fb1
https://doi.org/10.1038/s41586-021-03952-y
https://doi.org/10.1038/s41586-021-03952-y
Autor:
Christopher H. van Dyck, Dibyadeep Datta, Tamas L. Horvath, Shannon N. Leslie, Pasko Rakic, Yury M. Morozov, Min Wang, Alvaro Duque, Angus C Nairn, Sheng-Tao Yang, SueAnn Mentone, Amy F.T. Arnsten, Caroline Zeiss
Publikováno v:
Alzheimer's & Dementia
Introduction The etiology of sporadic Alzheimer's disease (AD) requires non‐genetically modified animal models. Methods The relationship of tau phosphorylation to calcium‐cyclic adenosine monophosphate (cAMP)‐protein kinase A (PKA) dysregulatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e57d77f075309e5d6a1bc5f840e2cfba
http://europepmc.org/articles/PMC8195842
http://europepmc.org/articles/PMC8195842
Publikováno v:
Neurochem Res
Radial glial cells (RGC) are at the center of brain development in vertebrates, acting as progenitors for neurons and macroglia (oligodendrocytes and astrocytes) and as guides for migration of neurons from the ventricular surface to their final posit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905fd3aab177fb0f0324f0d8236f0e31
https://doi.org/10.1007/s11064-021-03296-z
https://doi.org/10.1007/s11064-021-03296-z
Autor:
Shengtao Yang, Dibyadeep Datta, null Elizabeth Woo, Alvaro Duque, Yury M. Morozov, Jon Arellano, Barbara S. Slusher, Min Wang, Amy F. T. Arnsten
Publikováno v:
Molecular psychiatry. 27(10)
Glutamate carboxypeptidase-II (GCPII) expression in brain is increased by inflammation, e.g. by COVID19 infection, where it reduces NAAG stimulation of metabotropic glutamate receptor type 3 (mGluR3). GCPII-mGluR3 signaling is increasingly linked to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b93cdeac0187b598757c680185977c2
https://pubmed.ncbi.nlm.nih.gov/35732693
https://pubmed.ncbi.nlm.nih.gov/35732693
Autor:
Ton DeGrauw, Yuancheng Li, Xiaohui Zhang-Brotzge, Hui Mao, Elizabeth M. Fugate, Chia-Yi Kuan, Pasko Rakic, Hong-Ru Chen, Yury M. Morozov, Yu-Yo Sun, Irena S. Kuan, Siming Wang, Helen Heju Zhang, Diana M. Lindquist
Publikováno v:
JCI Insight
The creatine transporter (CrT) maintains brain creatine (Cr) levels, but the effects of its deficiency on energetics adaptation under stress remain unclear. There are also no effective treatments for CrT deficiency, the second most common cause of X-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402f35678a4814bd4fcc0017ba50b842
https://doi.org/10.1172/jci.insight.140173
https://doi.org/10.1172/jci.insight.140173