Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Yuru, Tong"'
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract The large superfamily of labdane-related diterpenoids is defined by the cyclization of linear geranylgeranyl pyrophosphate (GGPP), catalyzed by copalyl diphosphate synthases (CPSs) to form the basic decalin core, the copalyl diphosphates (CP
Externí odkaz:
https://doaj.org/article/1b7cebd16a274e3994bc38ccbda50883
Autor:
Yifeng Zhang, Jie Gao, Lin Ma, Lichan Tu, Tianyuan Hu, Xiaoyi Wu, Ping Su, Yujun Zhao, Yuan Liu, Dan Li, Jiawei Zhou, Yan Yin, Yuru Tong, Huan Zhao, Yun Lu, Jiadian Wang, Wei Gao, Luqi Huang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Hydroxylation at the C-14 position of triptolide is critical for its potent antitumor activity. Here, the authors report two CYP82Ds catalyze the 14-hydroxylation reaction via metabolic grid and achieve heterologous bioproduction of triptolide precur
Externí odkaz:
https://doaj.org/article/8f1d7a79fa8648128749819edecb4940
Autor:
Lichan Tu, Xinbo Cai, Yifeng Zhang, Yuru Tong, Jian Wang, Ping Su, Yun Lu, Tianyuan Hu, Yunfeng Luo, Xiaoyi Wu, Dan Li, Luqi Huang, Wei Gao
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 6, Pp 2923-2933 (2022)
Tripterygium wilfordii is a valuable medicinal plant rich in biologically active diterpenoids, but there are few studies on the origins of these diterpenoids in its secondary metabolism. Here, we identified three regions containing tandemly duplicate
Externí odkaz:
https://doaj.org/article/3125c298d4c84fbdabb39e3f0bbbc0d9
Autor:
Yadi Song, Jiawei Zhou, Yifeng Zhang, Yujun Zhao, Xiujuan Wang, Tianyuan Hu, Yuru Tong, Luqi Huang, Wei Gao
Publikováno v:
Frontiers in Plant Science, Vol 13 (2022)
Squalene synthase (SQS), squalene epoxidase (SE), and oxidosqualene cyclase (OSC) are encoding enzymes in downstream biosynthetic pathway of triterpenoid in plants, but the relationship between three genes and celastrol accumulation in Tripterygium w
Externí odkaz:
https://doaj.org/article/1911cb9fb3f747c482fa11f4c11d2697
Autor:
Lichan Tu, Ping Su, Zhongren Zhang, Linhui Gao, Jiadian Wang, Tianyuan Hu, Jiawei Zhou, Yifeng Zhang, Yujun Zhao, Yuan Liu, Yadi Song, Yuru Tong, Yun Lu, Jian Yang, Cao Xu, Meirong Jia, Reuben J. Peters, Luqi Huang, Wei Gao
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Tripterygium wilfordii is a medical plant that can produce antitumor activity compound triptolide. Here, the authors assemble its genome and identify a cytochrome P450 that can catalyze oxidation of a methyl to the acid moiety of dehydroabietic acid
Externí odkaz:
https://doaj.org/article/607c6a54fa534ef7bf5d30b6aa59d9b0
Investigating the Catalytic Activity of Glycosyltransferase on Quercetin from Tripterygium wilfordii
Publikováno v:
ACS Omega, Vol 5, Iss 3, Pp 1414-1421 (2020)
Externí odkaz:
https://doaj.org/article/bf0eccdc730f4f01b3b725653f0e815c
Autor:
Zhouqian Jiang, Lichan Tu, Weifei Yang, Yifeng Zhang, Tianyuan Hu, Baowei Ma, Yun Lu, Xiuming Cui, Jie Gao, Xiaoyi Wu, Yuru Tong, Jiawei Zhou, Yadi Song, Yuan Liu, Nan Liu, Luqi Huang, Wei Gao
Publikováno v:
Plant Communications, Vol 2, Iss 1, Pp 100113- (2021)
Panax notoginseng, a perennial herb of the genus Panax in the family Araliaceae, has played an important role in clinical treatment in China for thousands of years because of its extensive pharmacological effects. Here, we report a high-quality refer
Externí odkaz:
https://doaj.org/article/3e3e8893f888458cbb786189c636c23f
Autor:
Hongyu Guan, Yujun Zhao, Ping Su, Yuru Tong, Yujia Liu, Tianyuan Hu, Yifeng Zhang, Xianan Zhang, Jia Li, Xiaoyi Wu, Luqi Huang, Wei Gao
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 7, Iss 5, Pp 603-609 (2017)
Sterol C24-methyltransferase (SMT) plays multiple important roles in plant growth and development. SMT1, which belongs to the family of transferases and transforms cycloartenol into 24-methylene cycloartenol, is involved in the biosynthesis of 24-met
Externí odkaz:
https://doaj.org/article/97a72ea768a247f5be650fd52fb391c1
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 7, Iss 2, Pp 208-214 (2017)
The 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (HDR) is the last step key enzyme of the methylerythritol phosphate (MEP) pathway, synthesizing isopentenyl diphosphate and its allyl isomer dimethylallyl diphosphate, which is important for regu
Externí odkaz:
https://doaj.org/article/f38864ab7156411aa850d4caa97fe4b9
Autor:
Kang Chen, Juan Liu, Ruifeng Ji, Tong Chen, Xiuteng Zhou, Jian Yang, Yuru Tong, Chao Jiang, Junhui Zhou, Yuyang Zhao, Yan Jin, Yuan Yuan, Luqi Huang
Publikováno v:
Frontiers in Plant Science, Vol 9 (2019)
Ginseng, the root and rhizome of Panax ginseng C. A. Mey., is a well-known and valuable traditional Chinese medicine. The pharmacological activities of ginseng are mainly attributed to the presence of ginsenosides, which are considered to be critical
Externí odkaz:
https://doaj.org/article/12f8982cebbf40758d2cd11e6ba37162