Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Yurong Xin"'
Autor:
Charleen Hunt, Suzanne A. Hartford, Derek White, Evangelos Pefanis, Timothy Hanna, Clarissa Herman, Jarrell Wiley, Heather Brown, Qi Su, Yurong Xin, Dennis Voronin, Hien Nguyen, Judith Altarejos, Keith Crosby, Jeffery Haines, Sarah Cancelarich, Meghan Drummond, Sven Moller-Tank, Ryan Malpass, Jacqueline Buckley, Maria del Pilar Molina-Portela, Gustavo Droguett, David Frendewey, Eric Chiao, Brian Zambrowicz, Guochun Gong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
CRISPR-Cas9 is a gene editing tool that can be used to modulate gene expression. Here, the authors report the generation of a mouse model that express all components of the CRISPR-Cas9 guide directed Synergistic Activation Mediator (SAM), demonstrate
Externí odkaz:
https://doaj.org/article/17fb14b41cbb4fa7890fbff2faf8ff19
Autor:
Lina Sui, Qian Du, Anthony Romer, Qi Su, Pauline L. Chabosseau, Yurong Xin, Jinrang Kim, Sandra Kleiner, Guy A. Rutter, Dieter Egli
Publikováno v:
Cells, Vol 12, Iss 6, p 903 (2023)
The rare SLC30A8 mutation encoding a truncating p.Arg138* variant (R138X) in zinc transporter 8 (ZnT8) is associated with a 65% reduced risk for type 2 diabetes. To determine whether ZnT8 is required for beta cell development and function, we derived
Externí odkaz:
https://doaj.org/article/2e43616b294242a89cdd4004b2b2d738
Autor:
Qi Su, Sun Y. Kim, Funmi Adewale, Ye Zhou, Christina Aldler, Min Ni, Yi Wei, Michael E. Burczynski, Gurinder S. Atwal, Mark W. Sleeman, Andrew J. Murphy, Yurong Xin, Xiping Cheng
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103233- (2021)
Summary: Nonalcoholic fatty liver disease (NAFLD) is a global health-care problem with limited therapeutic options. To obtain a cellular resolution of pathogenesis, 82,168 single-cell transcriptomes (scRNA-seq) across different NAFLD stages were prof
Externí odkaz:
https://doaj.org/article/0cf76087cfa044fd89ddbc08a3f3891a
Reduced replication fork speed promotes pancreatic endocrine differentiation and controls graft size
Autor:
Lina Sui, Yurong Xin, Qian Du, Daniela Georgieva, Giacomo Diedenhofen, Leena Haataja, Qi Su, Michael V. Zuccaro, Jinrang Kim, Jiayu Fu, Yuan Xing, Yi He, Danielle Baum, Robin S. Goland, Yong Wang, Jose Oberholzer, Fabrizio Barbetti, Peter Arvan, Sandra Kleiner, Dieter Egli
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
Limitations in cell proliferation are important for normal function of differentiated tissues and essential for the safety of cell replacement products made from pluripotent stem cells, which have unlimited proliferative potential. To evaluate whethe
Externí odkaz:
https://doaj.org/article/e40875517d8941f9a40856ae37cd467f
Autor:
Fabienne Billiard, Sevasti Karaliota, Bei Wang, Dimitrios Stellas, Ioannis Serafimidis, Antigoni Manousopoulou, Yiassemi Koutmani, Elpiniki Ninou, Jacquelynn Golubov, Amanda DaNave, Panagiotis Tsakanikas, Yurong Xin, Wen Zhang, Matthew Sleeman, George D. Yancopoulos, Andrew J. Murphy, Spiros D. Garbis, Katia Karalis, Dimitris Skokos
Publikováno v:
Cell Reports, Vol 22, Iss 4, Pp 895-904 (2018)
Although Notch signaling has been proposed as a therapeutic target for type-2 diabetes, liver steatosis, and atherosclerosis, its direct effect on pancreatic islets remains unknown. Here, we demonstrated a function of Dll4-Notch signaling inhibition
Externí odkaz:
https://doaj.org/article/903bd16654ce4a97829d73e1cec13363
Autor:
Liheng Wang, Lina Sui, Sunil K. Panigrahi, Kana Meece, Yurong Xin, Jinrang Kim, Jesper Gromada, Claudia A. Doege, Sharon L. Wardlaw, Dieter Egli, Rudolph L. Leibel
Publikováno v:
Stem Cell Reports, Vol 8, Iss 2, Pp 264-277 (2017)
We recently developed a technique for generating hypothalamic neurons from human pluripotent stem cells. Here, as proof of principle, we examine the use of these cells in modeling of a monogenic form of severe obesity: PCSK1 deficiency. The cognate e
Externí odkaz:
https://doaj.org/article/e9b71508a7c14ae29cd2e768a39f802f
Publikováno v:
Molecular Metabolism, Vol 27, Iss , Pp S7-S14 (2019)
Background: Human pancreatic β-cells are heterogeneous. This has been known for a long time and is based on various functional and morphological readouts. β-Cell heterogeneity could reflect fixed subpopulations with distinct functions. However, rec
Externí odkaz:
https://doaj.org/article/1542130399e64b98b1a7b2620c7795f8
Autor:
Viktoria Gusarova, Corey A. Alexa, Yan Wang, Ashique Rafique, Jee Hae Kim, David Buckler, Ivory J. Mintah, Lisa M. Shihanian, Jonathan C. Cohen, Helen H. Hobbs, Yurong Xin, David M. Valenzuela, Andrew J. Murphy, George D. Yancopoulos, Jesper Gromada
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 7, Pp 1308-1317 (2015)
Angiopoietin-like protein 3 (ANGPTL3) is a circulating protein synthesized exclusively in the liver that inhibits LPL and endothelial lipase (EL), enzymes that hydrolyze TGs and phospholipids in plasma lipoproteins. Here we describe the development a
Externí odkaz:
https://doaj.org/article/275672f16b71425392895eda92f8dd5f
Publikováno v:
Bioinformatics and Biology Insights, Vol 2008, Iss 2, Pp 75-94 (2008)
Externí odkaz:
https://doaj.org/article/d5fd8fe3e6e1443fa2ba690161957d30
Publikováno v:
Bioinformatics and Biology Insights, Vol 2, Pp 77-95 (2008)
Recent studies of mammalian transcriptomes have identified numerous RNA transcripts that do not code for proteins; their identity, however, is largely unknown. Here we explore an approach based on sequence randomness patterns to discern different RNA
Externí odkaz:
https://doaj.org/article/39e982733fd9469781bbe6633b1ac632