A rare CACNA1H variant associated with amyotrophic lateral sclerosis causes complete loss of Cav3.2 T-type channel activity

Autor: Robin N. Stringer, Bohumila Jurkovicova-Tarabova, Sun Huang, Omid Haji-Ghassemi, Romane Idoux, Anna Liashenko, Ivana A. Souza, Yuriy Rzhepetskyy, Lubica Lacinova, Filip Van Petegem, Gerald W. Zamponi, Roger Pamphlett, Norbert Weiss

Publikováno v: Molecular Brain, Vol 13, Iss 1, Pp 1-11 (2020)

Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the progressive loss of cortical, brain stem and spinal motor neurons that leads to muscle weakness and death. A previous study implicated CACNA1H encoding

Externí odkaz: https://doaj.org/article/aa77ecf927be4dd78a092c2d4008c1cd

A potential role for T-type calcium channels in homocysteinemia-induced peripheral neuropathy

Autor: Leos Cmarko, Norbert Weiss, Aisylu S. Gaifullina, Gulshat Burkhanova, Guzel F. Sitdikova, Joanna Lazniewska, Elena Gerasimova, Andriy Tomin, Junting Huang, Paula Rivas-Ramirez, Yuriy Rzhepetskyy, Gerald W. Zamponi

Publikováno v: Pain. 160:2798-2810

Homocysteinemia is a metabolic condition characterized by abnormally high level of homocysteine in the blood and is considered to be a risk factor for peripheral neuropathy. However, the cellular mechanisms underlying toxic effects of homocysteine on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db67dee63b6659f1a6d93c0581f684f
https://doi.org/10.1097/j.pain.0000000000001669

Involvement of unconventional myosin VI in myoblast function and myotube formation

Autor: Yuriy Rzhepetskyy, Natalia Nowak, Pawel Niewiadomski, Justyna Karolczak, Maria Jolanta Redowicz, Iuliia Pavlyk, Łukasz Majewski, Tomasz J. Prószyński, Elisabeth Ehler, Magdalena Sobczak, Paweł Pomorski, Agata Sikorska

Publikováno v: Histochemistry and Cell Biology
Karolczak, J, Pavlyk, I, Majewski, Ł, Sobczak, M, Niewiadomski, P, Rzhepetskyy, Y, Sikorska, A, Nowak, N, Pomorski, P, Prószyński, T, Ehler, E & Rędowicz, M J 2015, ' Involvement of unconventional myosin VI in myoblast function and myotube formation ', Histochemistry and Cell Biology, vol. 144, no. 1, pp. 21-38 . https://doi.org/10.1007/s00418-015-1322-6

The important role of unconventional myosin VI (MVI) in skeletal and cardiac muscle has been recently postulated (Karolczak et al. in Histochem Cell Biol 139:873–885, 2013). Here, we addressed for the first time a role for this unique myosin motor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a00117666741ff6f255c54f2ed322a
https://doi.org/10.1007/s00418-015-1322-6

Nitric oxide donor augments antineoplastic effects of arginine deprivation in human melanoma cells

Autor: Iuliia Pavlyk, Maryna Barska, Oksana Mayevska, N. I. Igumentseva, Maria Jolanta Redowicz, Oleh Chen, Liliana Lyniv, Yaroslav Bobak, Yuriy Rzhepetskyy, Olena Karatsai, Oleh V. Stasyk

Publikováno v: Experimental Cell Research

Anticancer therapy based on recombinant arginine-degrading enzymes has been proposed for the treatment of several types of malignant cells deficient in arginine biosynthesis. One of the predicted side effects of such therapy is restricted bioavailabi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa30d80199ccbf52394ef38c04d8d7a

CACNA1H missense mutations associated with amyotrophic lateral sclerosis alter Ca(v)3.2 T-type calcium channel activity and reticular thalamic neuron firing

Autor: Yuriy Rzhepetskyy, Joanna Lazniewska, Norbert Weiss, Iulia Blesneac, Roger Pamphlett

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. In a recent study by Steinberg and colleagues, 2 recessive missense mutations were identified in the Ca(v)3.2 T-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f68eb8613c972b98e5b7bf9a8d49ffb
https://hdl.handle.net/11541.2/127483