Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Yuriy Loskutov"'
Autor:
Yuriy Loskutov
The primary cilium is a ubiquitous organelle presented on most human cells. It serves as a crucial signaling hub for multiple pathways including growth factor and G-protein coupled receptors. Loss of primary cilia was observed in various cancers, how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31ec76191458a216a69a4eb3b705fac2
https://doi.org/10.33915/etd.6113
https://doi.org/10.33915/etd.6113
Autor:
Peter Stoilov, Elena N. Pugacheva, Visvanathan Ramamurthy, Daniel Murphy, Zachary C. Wright, Andrew F.X. Goldberg, Yuriy Loskutov
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports
Scientific Reports
Photoreceptor cells are specialized neurons with a sensory cilium carrying an elaborate membrane structure, the outer segment (OS). Inherited mutations in genes involved in ciliogenesis frequently result in OS malformation and blindness. ADP-ribosyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e26a679bc22528479f6391cbdb043324
http://link.springer.com/article/10.1038/s41598-018-35395-3
http://link.springer.com/article/10.1038/s41598-018-35395-3
Autor:
Jann N. Sarkaria, Werner J. Geldenhuys, Kristina M. Marinak, Naira V. Margaryan, Caryn L. Griffin, Elena N. Pugacheva, Yuriy Loskutov, Andrey A. Bobko
Publikováno v:
Oncogene
The primary cilium is a ubiquitous organelle presented on most human cells. It is a crucial signaling hub for multiple pathways including growth factor and G-protein coupled receptors. Loss of primary cilia, observed in various cancers, has been show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c4cab45bfbfcc98ac69b9c3f5d4915
http://europepmc.org/articles/PMC5854509
http://europepmc.org/articles/PMC5854509
Autor:
Matthew B. Smolkin, Sijin Wen, Mohamad Adham Salkeni, Neal Shah, Ginger Layne, Elena N. Pugacheva, Hannah Hazard, Ryan H. Livengood, Fatimah Matalkah, Greg W. Kilby, Kristina M. Marinak, Ryan J. Ice, Pamela S. Cantrell, Varvara K. Kozyreva, Callee M. Walsh, Sricharan Mahavadi, Anna A. Kiseleva, Brandon C. Jones, Yuriy Loskutov
Publikováno v:
Molecular Cancer Therapeutics. 15:1809-1822
Recent findings suggest that the inhibition of Aurora A (AURKA) kinase may offer a novel treatment strategy against metastatic cancers. In the current study, we determined the effects of AURKA inhibition by the small molecule inhibitor MLN8237 both a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14110c7f9d4d075a7a21fce55a9cbe03
https://doi.org/10.1158/1535-7163.mct-15-0688
https://doi.org/10.1158/1535-7163.mct-15-0688
Publikováno v:
Vestnik of Volga State University of Technology. Economics and Management. 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2936644a33196a4843409cde6ebf1920
https://doi.org/10.15350/2306-2800.2017.3.90
https://doi.org/10.15350/2306-2800.2017.3.90
Targeting primary cilia – associated signaling in glioblastoma: guided approach for drug development
Autor:
Yuriy Loskutov, Elena N. Pugacheva
Publikováno v:
Oncoscience
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d4e8a1eb4285efe8e110add4429247
http://europepmc.org/articles/PMC6382257
http://europepmc.org/articles/PMC6382257
Autor:
Polina Y. Kozyulina, Alexey V. Ivanov, Yuriy Loskutov, Matthew B. Smolkin, Ryan J. Ice, Brandon C. Jones, Elena N. Pugacheva, Varvara K. Kozyreva, Robert B. Wysolmerski, Trevor J. Roston
Publikováno v:
Oncogene
NEDD9 is an established marker of invasive and metastatic cancers. NEDD9 downregulation has been shown to dramatically reduce cell invasion and metastasis in multiple tumors. The mechanisms by which NEDD9 regulates invasion are largely unknown. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4bbbea3e71d51c506d70580539097f7
https://doi.org/10.1038/onc.2014.297
https://doi.org/10.1038/onc.2014.297
Autor:
Polina Y. Kozyulina, Ryan J. Ice, Anuradha Rajulapati, Alexey V. Ivanov, Varvara K. Kozyreva, Scott A. Weed, Yuriy Loskutov, Mark Culp, Ryan H. Livengood, Sarah L. McLaughlin, Elena N. Pugacheva
Publikováno v:
Molecular Cancer Research. 12:69-81
The scaffolding protein NEDD9 is an established prometastatic marker in several cancers. Nevertheless, the molecular mechanisms of NEDD9-driven metastasis in cancers remain ill-defined. Here, using a comprehensive breast cancer tissue microarray, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb94168d62fc5741042375f5021431c
https://doi.org/10.1158/1541-7786.mcr-13-0300
https://doi.org/10.1158/1541-7786.mcr-13-0300
Autor:
Matthew B. Smolkin, Elena N. Pugacheva, Kristina M. Marinak, Yuriy Loskutov, Anna A. Kiseleva
Publikováno v:
Cancer Research. 77:4863-4863
Aurora-A Kinase (AURKA) is a serine/threonine kinase that is critical for mitosis. AURKA is overexpressed in 96% of human cancers, including breast cancer. It has been previously shown that AURKA localizes to the nucleus in breast cancer metastases a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2ab6c920916aace89808b3b35d28b64
https://doi.org/10.1158/1538-7445.am2017-4863
https://doi.org/10.1158/1538-7445.am2017-4863
Autor:
Elena N. Pugacheva, Ryan J. Ice, Anna A. Kiseleva, Brandon C. Jones, Varvara K. Kozyreva, Yuriy Loskutov
Publikováno v:
Cancer Research. 77:1084-1084
The majority of cancer-related deaths (90%) are happened due to metastasis from the primary tumor site to distant organs. MLN8237 is a small, highly selective molecule inhibitor of Aurora A kinase (AURKA), which results in disruption of the mitotic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::282db0973ab39e83949dd0c1236a1293
https://doi.org/10.1158/1538-7445.am2017-1084
https://doi.org/10.1158/1538-7445.am2017-1084