A rare CACNA1H variant associated with amyotrophic lateral sclerosis causes complete loss of Cav3.2 T-type channel activity

Autor: Robin N. Stringer, Bohumila Jurkovicova-Tarabova, Sun Huang, Omid Haji-Ghassemi, Romane Idoux, Anna Liashenko, Ivana A. Souza, Yuriy Rzhepetskyy, Lubica Lacinova, Filip Van Petegem, Gerald W. Zamponi, Roger Pamphlett, Norbert Weiss

Publikováno v: Molecular Brain, Vol 13, Iss 1, Pp 1-11 (2020)

Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the progressive loss of cortical, brain stem and spinal motor neurons that leads to muscle weakness and death. A previous study implicated CACNA1H encoding

Externí odkaz: https://doaj.org/article/aa77ecf927be4dd78a092c2d4008c1cd

A potential role for T-type calcium channels in homocysteinemia-induced peripheral neuropathy

Autor: Leos Cmarko, Norbert Weiss, Aisylu S. Gaifullina, Gulshat Burkhanova, Guzel F. Sitdikova, Joanna Lazniewska, Elena Gerasimova, Andriy Tomin, Junting Huang, Paula Rivas-Ramirez, Yuriy Rzhepetskyy, Gerald W. Zamponi

Publikováno v: Pain. 160:2798-2810

Homocysteinemia is a metabolic condition characterized by abnormally high level of homocysteine in the blood and is considered to be a risk factor for peripheral neuropathy. However, the cellular mechanisms underlying toxic effects of homocysteine on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db67dee63b6659f1a6d93c0581f684f
https://doi.org/10.1097/j.pain.0000000000001669

Involvement of unconventional myosin VI in myoblast function and myotube formation

Autor: Yuriy Rzhepetskyy, Natalia Nowak, Pawel Niewiadomski, Justyna Karolczak, Maria Jolanta Redowicz, Iuliia Pavlyk, Łukasz Majewski, Tomasz J. Prószyński, Elisabeth Ehler, Magdalena Sobczak, Paweł Pomorski, Agata Sikorska

Publikováno v: Histochemistry and Cell Biology
Karolczak, J, Pavlyk, I, Majewski, Ł, Sobczak, M, Niewiadomski, P, Rzhepetskyy, Y, Sikorska, A, Nowak, N, Pomorski, P, Prószyński, T, Ehler, E & Rędowicz, M J 2015, ' Involvement of unconventional myosin VI in myoblast function and myotube formation ', Histochemistry and Cell Biology, vol. 144, no. 1, pp. 21-38 . https://doi.org/10.1007/s00418-015-1322-6

The important role of unconventional myosin VI (MVI) in skeletal and cardiac muscle has been recently postulated (Karolczak et al. in Histochem Cell Biol 139:873–885, 2013). Here, we addressed for the first time a role for this unique myosin motor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a00117666741ff6f255c54f2ed322a
https://doi.org/10.1007/s00418-015-1322-6

A Ca

Autor: Yuriy, Rzhepetskyy, Joanna, Lazniewska, Juliane, Proft, Marta, Campiglio, Bernhard E, Flucher, Norbert, Weiss

Publikováno v: Channels (Austin, Tex.). 10(5)

Low-voltage-activated T-type calcium channels are essential contributors to neuronal physiology where they play complex yet fundamentally important roles in shaping intrinsic excitability of nerve cells and neurotransmission. Aberrant neuronal excita

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7994164bcfe80c6def7da1ee150b517c
https://pubmed.ncbi.nlm.nih.gov/27682595

A Ca(v)3.2/Stac1 molecular complex controls T-type channel expression at the plasma membrane

Autor: Norbert Weiss, Joanna Lazniewska, Marta Campiglio, Yuriy Rzhepetskyy, Juliane Proft, Bernhard E. Flucher

Low-voltage-activated T-type calcium channels are essential contributors to neuronal physiology where they play complex yet fundamentally important roles in shaping intrinsic excitability of nerve cells and neurotransmission. Aberrant neuronal excita

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b77457ad59fb9f65e1c8ab9a2711ff
https://hdl.handle.net/11541.2/127495