Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Yuriy, Pomeshchik"'
Autor:
Erika Velasquez, Ekaterina Savchenko, Sara Marmolejo-Martínez-Artesero, Désiré Challuau, Aline Aebi, Yuriy Pomeshchik, Nuno Jorge Lamas, Mauno Vihinen, Melinda Rezeli, Bernard Schneider, Cedric Raoul, Laurent Roybon
Publikováno v:
Neurobiology of Disease, Vol 201, Iss , Pp 106687- (2024)
Astrocytes play a crucial role in the onset and progression of amyotrophic lateral sclerosis (ALS), a fatal disorder marked by the degeneration of motor neurons (MNs) in the central nervous system. Although astrocytes in ALS are known to be toxic to
Externí odkaz:
https://doaj.org/article/96141882157d42c4b7a55ed53795b7d5
Publikováno v:
eLife, Vol 12 (2024)
We previously showed that SerpinE2 and the serine protease HtrA1 modulate fibroblast growth factor (FGF) signaling in germ layer specification and head-to-tail development of Xenopus embryos. Here, we present an extracellular proteolytic mechanism in
Externí odkaz:
https://doaj.org/article/f9fa42b3bbc34106a36feee1d5d59562
Autor:
Yuriy Pomeshchik, Erika Velasquez, Jeovanis Gil, Oxana Klementieva, Ritha Gidlöf, Marie Sydoff, Silvia Bagnoli, Benedetta Nacmias, Sandro Sorbi, Gunilla Westergren-Thorsson, Gunnar K. Gouras, Melinda Rezeli, Laurent Roybon
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-19 (2023)
Abstract The hippocampus is a primary region affected in Alzheimer’s disease (AD). Because AD postmortem brain tissue is not available prior to symptomatic stage, we lack understanding of early cellular pathogenic mechanisms. To address this issue,
Externí odkaz:
https://doaj.org/article/2ae5b16d269b4929b5cc61c410c184d5
Autor:
Meike Hedwig Keuters, Velta Keksa-Goldsteine, Hiramani Dhungana, Mikko T. Huuskonen, Yuriy Pomeshchik, Ekaterina Savchenko, Paula K. Korhonen, Yajuvinder Singh, Sara Wojciechowski, Šárka Lehtonen, Katja M. Kanninen, Tarja Malm, Jouni Sirviö, Anu Muona, Milla Koistinaho, Gundars Goldsteins, Jari Koistinaho
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Lipid peroxidation-initiated ferroptosis is an iron-dependent mechanism of programmed cell death taking place in neurological diseases. Here we show that a condensed benzo[b]thiazine derivative small molecule with an arylthiazine backbone (A
Externí odkaz:
https://doaj.org/article/3ca87910b4fe497bb6a795384b53ddb2
Autor:
Paula Korhonen, Eveliina Pollari, Katja M. Kanninen, Ekaterina Savchenko, Šárka Lehtonen, Sara Wojciechowski, Yuriy Pomeshchik, Ludo Van Den Bosch, Gundars Goldsteins, Jari Koistinaho, Tarja Malm
Publikováno v:
IBRO Reports, Vol 6, Iss , Pp 74-86 (2019)
Inflammation is a prominent feature of the neuropathology of amyotrophic lateral sclerosis (ALS). Emerging evidence suggests that inflammatory cascades contributing to the disease progression are not restricted to the central nervous system (CNS) but
Externí odkaz:
https://doaj.org/article/02325ea1922447b59859bac28b3eff53
Autor:
Kaspar Russ, Gabriel Teku, Luc Bousset, Virginie Redeker, Sara Piel, Ekaterina Savchenko, Yuriy Pomeshchik, Jimmy Savistchenko, Tina C. Stummann, Carla Azevedo, Anna Collin, Stefano Goldwurm, Karina Fog, Eskil Elmer, Mauno Vihinen, Ronald Melki, Laurent Roybon
Publikováno v:
Cell Reports, Vol 34, Iss 12, Pp 108895- (2021)
Summary: Here, we examine the cellular changes triggered by tumor necrosis factor alpha (TNF-α) and different alpha-synuclein (αSYN) species in astrocytes derived from induced pluripotent stem cells. Human astrocytes treated with TNF-α display a s
Externí odkaz:
https://doaj.org/article/6a50af0ea3c9434abf2f85506059fa63
Autor:
Carla Azevedo, Margarita Chumarina, Evgenija Serafimova, Stefano Goldwurm, Anna Collin, Laurent Roybon, Ekaterina Savchenko, Yuriy Pomeshchik
Publikováno v:
Stem Cell Research, Vol 43, Iss , Pp - (2020)
Here, we describe the generation of an induced pluripotent stem cell (iPSC) line, from a male patient diagnosed with Parkinson's disease (PD). The patient carries a heterozygous variation p.A53T in the SNCA gene. Skin fibroblasts were reprogrammed us
Externí odkaz:
https://doaj.org/article/cd8b01eba06b4fadaf57462636202ac4
Autor:
Ana Marote, Yuriy Pomeshchik, Anna Collin, Stefano Goldwurm, Nuno J. Lamas, Luísa Pinto, António J. Salgado, Laurent Roybon
Publikováno v:
Stem Cell Research, Vol 28, Iss , Pp 44-47 (2018)
The leucine-rich repeat kinase 2 (LRRK2) p.G2019S mutation is the most common genetic cause of Parkinson's disease (PD). An induced pluripotent stem cell (iPSC) line CSC-41 was generated from a 75-year old patient diagnosed with PD caused by a p.G201
Externí odkaz:
https://doaj.org/article/3c1307d922004b9b8af5ea83b6878ec0
Autor:
Ana Marote, Yuriy Pomeshchik, Stefano Goldwurm, Anna Collin, Nuno J. Lamas, Luísa Pinto, António J. Salgado, Laurent Roybon
Publikováno v:
Stem Cell Research, Vol 27, Iss , Pp 82-85 (2018)
An induced pluripotent stem cell (iPSC) line was generated from a 36-year-old patient with sporadic Parkinson's disease (PD). Skin fibroblasts were reprogrammed using the non-integrating Sendai virus technology to deliver OCT3/4, SOX2, c-MYC and KLF4
Externí odkaz:
https://doaj.org/article/5144805d344f4ce49d2893555df895a8
Autor:
Ekaterina Savchenko, Ana Marote, Kaspar Russ, Anna Collin, Stefano Goldwurm, Laurent Roybon, Yuriy Pomeshchik
Publikováno v:
Stem Cell Research, Vol 27, Iss , Pp 78-81 (2018)
Skin fibroblasts were collected from a 44-year-old patient with sporadic case of Parkinson's disease (PD). The non-integrating Sendai virus vector encoding OCT3/4, SOX2, c-MYC and KLF4 was used to reprogram fibroblasts into induced pluripotent stem c
Externí odkaz:
https://doaj.org/article/4221f0ddd07a41e883ade90cf7152eb0