Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Yuri Yanishevski"'
Autor:
Yuri Yanishevski, Jeffrey E. Rubnitz, Raul C. Ribeiro, Ching-Hon Pui, John C. Panetta, Mary V. Relling, John T. Sandlund, Gaston K. Rivera, William E. Evans
Publikováno v:
Cancer Chemotherapy and Pharmacology. 50:419-428
Methotrexate (MTX) is one of the most widely used drugs for the treatment of childhood acute lymphoblastic leukemia (ALL). Interindividual differences in lymphoblast accumulation of MTX and its active metabolites, methotrexate polyglutamates (MTXPG),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52af56a66f9bd771b967539b10592d1e
https://doi.org/10.1007/s00280-002-0511-x
https://doi.org/10.1007/s00280-002-0511-x
Autor:
Vladimir M. Belkov, Eugene Y. Krynetski, John D. Schuetz, Yuri Yanishevski, Eric Masson, Susan Mathew, Susana Raimondi, Ching-Hon Pui, Mary V. Relling, William E. Evans
Publikováno v:
Blood. 93:1643-1650
Methotrexate (MTX) is one of the most active and widely used agents for the treatment of acute lymphoblastic leukemia (ALL). To elucidate the mechanism for higher accumulation of MTX polyglutamates (MTX-PG) in hyperdiploid ALL and lower accumulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8759cad15270b7dba8c98c6b6d53590
https://doi.org/10.1182/blood.v93.5.1643.405k06_1643_1650
https://doi.org/10.1182/blood.v93.5.1643.405k06_1643_1650
Autor:
John D. Schuetz, Eugene Y. Krynetski, Eric Masson, Susan Mathew, Ching-Hon Pui, Vladimir M. Belkov, William E. Evans, Mary V. Relling, Yuri Yanishevski, Susana C. Raimondi
Publikováno v:
Blood. 93:1643-1650
Methotrexate (MTX) is one of the most active and widely used agents for the treatment of acute lymphoblastic leukemia (ALL). To elucidate the mechanism for higher accumulation of MTX polyglutamates (MTX-PG) in hyperdiploid ALL and lower accumulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::459c81c1cd1f5e1c50fc7c6ba0d0316d
https://doi.org/10.1182/blood.v93.5.1643
https://doi.org/10.1182/blood.v93.5.1643
Autor:
C H Pui, Frederick G. Behm, James M. Boyett, Mary V. Relling, Yuri Yanishevski, William E. Evans, J. Nemec
Publikováno v:
Leukemia. 12:346-352
Etoposide, an effective agent for acute lymphoblastic leukemia (ALL), can cause secondary acute myeloid leukemia (AML) in a subset of patients. Our objectives were to determine whether patients who develop secondary AML displayed altered etoposide ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a4be02c5670cfb53f6d750a7d19b8b2
https://doi.org/10.1038/sj.leu.2400928
https://doi.org/10.1038/sj.leu.2400928
Autor:
Timothy W. Synold, Ching Hon Pui, Julio C. Barredo, John D. Schuetz, Yuri Yanishevski, Mary V. Relling, Eric Masson, William E. Evans, Amy J. Galpin
Publikováno v:
Molecular Pharmacology. 52:155-163
Cellular accumulation of methotrexate polyglutamates (MTXPGs) is recognized as an important determinant of the cytotoxicity and selectivity of methotrexate in acute lymphoblastic leukemia (ALL). We identified a significantly lower cellular accumulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d74e29ad513e1d9712631994a7e4f67e
https://doi.org/10.1124/mol.52.1.155
https://doi.org/10.1124/mol.52.1.155
Autor:
Dorothea E. Myers, Fatih M. Uckun, James D. Irvin, Eric Masson, Yuri Yanishevski, William E. Evans
Publikováno v:
Leukemia & Lymphoma. 18:93-102
Standard immunotoxin production procedures using whole IgG as the MoAb moiety yield a heterogeneous mixture of 180 kDa, 210 kDa, and 240 kDa immunotoxin species with 1 to 1, 1 to 2, and 1 to 3 MoAb to toxin ratios. This heterogeneity makes it impossi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5a56b5b8cd90edc938d7da296c447f
https://doi.org/10.3109/10428199509064928
https://doi.org/10.3109/10428199509064928
Autor:
Roland Gunther, Dorothea E. Myers, Waurzyniak B, Mridula Chandan-Langlie, Lisa M. Chelstrom, Schneider E, Tamer Zeren, Yuri Yanishevski, Onur Ek, Fatih M. Uckun, William E. Evans
Publikováno v:
Leukemialymphoma. 30(3-4)
B43(anti-CD19)-Genistein immunoconjugate targets genistein, a naturally occurring protein tyrosine kinase inhibitory isoflavone to the membrane-associated anti-apoptotic CD19-LYN complexes and triggers apoptotic cell death. In this preclinical study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09dabc79d9cf07f5f0e0bbdb8080977b
https://pubmed.ncbi.nlm.nih.gov/9713969
https://pubmed.ncbi.nlm.nih.gov/9713969