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Gene correction by 5′-tailed duplexes with short editor oligodeoxyribonucleotides

Autor: Ryotaro Kamitsubo, Hidehiko Kawai, Kentaro Yazama, Yuri Yanai, Hiroyuki Kamiya

Publikováno v: Journal of Bioscience and Bioengineering. 132:552-559

Various diseases, including cancer, are caused by genetic mutations. A 5'-tailed duplex (TD) DNA, consisting of a long single-stranded (ss) editor DNA and a short (∼35-base) ss assistant oligodeoxyribonucleotide, can introduce a base-substitution i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9c6dca29a2c746136ff1e2fe188de70
https://doi.org/10.1016/j.jbiosc.2021.08.012

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Effects of mismatches distant from the target position on gene correction with a 5'-tailed duplex

Autor: Yuri Yanai, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Natsuki Nishigaki, Tetsuya Suzuki, Hiroyuki Kamiya

Publikováno v: Journal of bioscience and bioengineering. 125(5)

The introduction of a 5′-tailed duplex (5′-TD) fragment into cells corrects a base-substitution mutation in a target DNA. We previously reported that the gene correction efficiency was improved when a frameshift type of second mismatch was presen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30ac1366238c81a66b2ad96fc3078379
https://pubmed.ncbi.nlm.nih.gov/29361419

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