Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Yuri V. Mezentsev"'
Publikováno v:
Biomedicines, Vol 12, Iss 3, p 544 (2024)
Malignant neoplasms are characterized by high molecular heterogeneity due to multilevel deregulation of gene expression and cellular functions. It is known that non-coding RNAs, including long intergenic non-coding RNAs (lincRNAs), can play significa
Externí odkaz:
https://doaj.org/article/b961e202ed954b91b6ef1252e5265c63
Autor:
Tatsiana V. Tsybruk, Leonid A. Kaluzhskiy, Yuri V. Mezentsev, Tatyana N. Makarieva, Kseniya M. Tabakmaher, Natalia V. Ivanchina, Pavel S. Dmitrenok, Alexander V. Baranovsky, Andrei A. Gilep, Alexis S. Ivanov
Publikováno v:
Biomedicines, Vol 11, Iss 11, p 2873 (2023)
Due to the increasing prevalence of fungal diseases caused by fungi of the genus Candida and the development of pathogen resistance to available drugs, the need to find new effective antifungal agents has increased. Azole antifungals, which are inhib
Externí odkaz:
https://doaj.org/article/2405999c00fc4866a1202feaf5e17b59
Autor:
Pavel V. Ershov, Evgeniy O. Yablokov, Leonid A. Kaluzhskiy, Yuri V. Mezentsev, Alexis S. Ivanov
Publikováno v:
Biology, Vol 11, Iss 4, p 590 (2022)
Cancer-associated disturbance of prostanoid signaling provides an aberrant accumulation of prostanoids. This signaling consists of 19 target genes, encoding metabolic enzymes and G-protein-coupled receptors, and prostanoids (prostacyclin, thromboxane
Externí odkaz:
https://doaj.org/article/7f4224464eaa4a7d9d0b121d5a2f4e3e
Publikováno v:
Biomolecules, Vol 12, Iss 1, p 106 (2022)
The identification of disease-related protein-protein interactions (PPIs) creates objective conditions for their pharmacological modulation. The contact area (interfaces) of the vast majority of PPIs has some features, such as geometrical and biochem
Externí odkaz:
https://doaj.org/article/82c5043a265c46c884043d0a2b5f0223
Autor:
Pavel V. Ershov, Alexander V. Veselovsky, Yuri V. Mezentsev, Evgeniy O. Yablokov, Leonid A. Kaluzhskiy, Anastasiya M. Tumilovich, Anton A. Kavaleuski, Andrei A. Gilep, Taisiya V. Moskovkina, Alexei E. Medvedev, Alexis S. Ivanov
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 20, p 7605 (2020)
Isatin (indole-2, 3-dione) is a non-peptide endogenous bioregulator exhibiting a wide spectrum of biological activity, realized in the cell via interactions with numerous isatin-binding proteins, their complexes, and (sub) interactomes. There is incr
Externí odkaz:
https://doaj.org/article/de1da341bf0d4f15b7246e5fcd4b4a3f
Autor:
Evgeny P. Barykin, Aleksandra I. Garifulina, Anna P. Tolstova, Anastasia A. Anashkina, Alexei A. Adzhubei, Yuri V. Mezentsev, Irina V. Shelukhina, Sergey A. Kozin, Victor I. Tsetlin, Alexander A. Makarov
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 17, p 6272 (2020)
The cholinergic deficit in Alzheimer’s disease (AD) may arise from selective loss of cholinergic neurons caused by the binding of Aβ peptide to nicotinic acetylcholine receptors (nAChRs). Thus, compounds preventing such an interaction are needed t
Externí odkaz:
https://doaj.org/article/d40d51ea72884a459e151d1111a735e0
Autor:
Pavel V. Ershov, Yuri V. Mezentsev, Arthur T. Kopylov, Evgeniy O. Yablokov, Andrey V. Svirid, Aliaksandr Ya. Lushchyk, Leonid A. Kaluzhskiy, Andrei A. Gilep, Sergey A. Usanov, Alexey E. Medvedev, Alexis S. Ivanov
Publikováno v:
Biology, Vol 8, Iss 2, p 49 (2019)
Prostacyclin synthase (PTGIS; EC 5.3.99.4) catalyzes isomerization of prostaglandin H2 to prostacyclin, a potent vasodilator and inhibitor of platelet aggregation. At present, limited data exist on functional coupling and possible ways of regulating
Externí odkaz:
https://doaj.org/article/7c46b9e2b62d4e7d923f8b00dca1f146
Autor:
Olga I. Kechko, Sergey A. Kozin, Alexey B. Mantsyzov, Alexander A. Makarov, Alexei E. Medvedev, Yuri V. Mezentsev, Andrew Ivanov
Publikováno v:
Journal of biomolecular structuredynamics. 34(11)
Zinc ions and modified amyloid-beta peptides (Aβ) play a critical role in the pathological aggregation of endogenous Aβ in Alzheimer’s disease (AD). Zinc-induced Aβ oligomerization is mediated by the metal-binding domain (MBD) which includes N-t