Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Yuri V Svitkin"'
Autor:
Yuri V Svitkin, Akiko Yanagiya, Alexey E Karetnikov, Tommy Alain, Marc R Fabian, Arkady Khoutorsky, Sandra Perreault, Ivan Topisirovic, Nahum Sonenberg
Publikováno v:
PLoS Biology, Vol 11, Iss 5, p e1001564 (2013)
Translation control often operates via remodeling of messenger ribonucleoprotein particles. The poly(A) binding protein (PABP) simultaneously interacts with the 3' poly(A) tail of the mRNA and the eukaryotic translation initiation factor 4G (eIF4G) t
Externí odkaz:
https://doaj.org/article/5d4447b8a6e4451abab1f66500713155
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11607 (2010)
DCB-3503, a tylophorine analog, inhibits the growth of PANC-1 (human pancreatic ductal cancer cell line) and HepG2 (human hepatocellular cancer cell line) tumor xenografts in nude mice. The inhibition of growth leads to cancer cell differentiation in
Externí odkaz:
https://doaj.org/article/2ee5a0ca95cf4e409e33539c654d94d4
Autor:
Alejandro García-Carrancá, Giovanna Maldonado, Nahum Sonenberg, Greco Hernández, David Cantú, Yuri V. Svitkin, Jose L. González, Alejandra García
Publikováno v:
Proc Natl Acad Sci U S A
Cervical cancer is the fourth most common cause of cancer in women worldwide in terms of both incidence and mortality. Persistent infection with high-risk types of human papillomavirus (HPV), namely 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b09239463d6cce920414eeb1cd6a5e9
https://pubmed.ncbi.nlm.nih.gov/34615711
https://pubmed.ncbi.nlm.nih.gov/34615711
Publikováno v:
Proc Natl Acad Sci U S A
> There was a blizzard on the earth, In every corner, A candle was burning on the desk A candle burning > > Boris Pasternak, 1946 Alexander Sergeevich Spirin, an international member of the National Academy of Sciences, recited this poem by Boris Pas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0efa538009fd481a2ec13aecb5f2df89
https://doi.org/10.1073/pnas.2103938118
https://doi.org/10.1073/pnas.2103938118
Autor:
Takuhiro Ito, Yuri V. Svitkin, Nahum Sonenberg, Hiroaki Imataka, Yuki Yamamoto, Tomoaki Shigeta, Kodai Machida
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports
Scientific Reports
Eukaryotic mRNA has a cap structure and a poly(A) tail at the 5′ and 3′ ends, respectively. The cap structure is recognized by eIF (eukaryotic translation initiation factor) 4 F, while the poly(A) tail is bound by poly(A)-binding protein (PABP).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7913d377dd841070230a04f5bdce2922
http://link.springer.com/article/10.1038/s41598-018-35753-1
http://link.springer.com/article/10.1038/s41598-018-35753-1
Publikováno v:
eLS
The major mechanism of translation initiation in eukaryotes involves recognition of the cap structure at the 5′ end of the mRNA by the cap-binding protein eIF4E. Internal ribosome entry sites (IRES) are specialised RNA sequences that are capable of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af4f14b16b31d7e365d3cf5a43df2dfe
https://doi.org/10.1002/9780470015902.a0000544.pub3
https://doi.org/10.1002/9780470015902.a0000544.pub3
Autor:
Matthias John, Tirtha Chakraborty, Nahum Sonenberg, Yuri V. Svitkin, Yi Min Cheng, Vladimir Presnyak
Publikováno v:
Nucleic Acids Research
Certain chemical modifications confer increased stability and low immunogenicity to in vitro transcribed mRNAs, thereby facilitating expression of therapeutically important proteins. Here, we demonstrate that N1-methyl-pseudouridine (N1mΨ) outperfor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512e629d27771b5f71b50beb6769c2eb
https://pubmed.ncbi.nlm.nih.gov/28334758
https://pubmed.ncbi.nlm.nih.gov/28334758
In eukaryotes, the major mechanism of translation initiation involves recognition of the cap structure at the 5′ end of the mRNA by a cap-binding protein, eIF4E. An internal ribosome entry site (IRES) is a specialized RNA element that recruits the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ff679ae539a4b988686455a7b54689c
https://doi.org/10.1016/b978-0-12-394447-4.30042-6
https://doi.org/10.1016/b978-0-12-394447-4.30042-6
Autor:
Nahum Sonenberg, Eigo Suyama, Hironori Adachi, Yvan Martineau, Ze'ev Ronai, Hiroaki Imataka, Yuri V. Svitkin, Pedro Aza-Blanc, Satoshi Mikami, Akiko Yanagiya
Publikováno v:
Molecular Cell. 46:847-858
Translational control of gene expression plays a key role in many biological processes. Consequently, the activity of the translation apparatus is under tight homeostatic control. eIF4E, the mRNA 5′ cap-binding protein, facilitates cap-dependent tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e140c39d734fe81069a247e406e4ff45
https://doi.org/10.1016/j.molcel.2012.04.004
https://doi.org/10.1016/j.molcel.2012.04.004
Autor:
Christos G. Gkogkas, Nahum Sonenberg, David Shahbazian, William C. Merrick, Armen Parsyan, Yuri V. Svitkin, Paul Lasko
Publikováno v:
Nature Reviews Molecular Cell Biology. 12:235-245
The translation initiation step in eukaryotes is highly regulated and rate-limiting. During this process, the 40S ribosomal subunit is usually recruited to the 5' terminus of the mRNA. It then migrates towards the initiation codon, where it is joined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55d37922374e45682da6f9696674e617
https://doi.org/10.1038/nrm3083
https://doi.org/10.1038/nrm3083