Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Yuri Umetsu"'
Publikováno v:
The Proceedings of the Dynamics & Design Conference. 2019:513
Autor:
Yuki Takahashi, Masami Miyamoto, Kanzo Kimura, Yuri Umetsu, Satoshi Daigo, Noritaka Ariyoshi, Philippe Beaune, Tetsuya Kamataki, Tsuyoshi Yokoi, Ken-ichi Nunoya
Publikováno v:
Drug Metabolism and Pharmacokinetics. 15:57-61
CYP2A6 has been characterized as a coumarin 7-hydroxylase in humans. A large interindividual difference in the activity of coumarin 7-hydroxylation suggested an existence of genetic polymorphism of this enzyme. In fact, CYP2A6*2 variant allele which
Autor:
Hideo Kunitoh, Masami Miyamoto, Jun Yokota, Nobuo Nemoto, Noritaka Ariyoshi, Hirotoshi Dosaka-Akita, Kunio Sato, Yuichi Sawamura, Yuri Umetsu, Tetsuya Kamataki
Publikováno v:
Biochemical and Biophysical Research Communications. 261:658-660
CYP2A6 is an enzyme with a high ability to activate a nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), to its potent and ultimate carcinogen. In the present study, we investigated the relationship between genetic polymorphism of CYP
Autor:
Noritaka, Ariyoshi, Masami, Miyamoto, Yuri, Umetsu, Hideo, Kunitoh, Hirotoshi, Dosaka-Akita, Yu-Ichi, Sawamura, Jun, Yokota, Nobuo, Nemoto, Kunio, Sato, Tetsuya, Kamataki
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 11(9)
Cytochrome P450 2A6 (CYP2A6) is the principal enzyme involved in the metabolic activation of tobacco-specific nitrosamines to their ultimate carcinogenic forms and metabolism of nicotine. We investigated the effects of the CYP2A6*4, an entire CYP2A6
Autor:
Tomonori Tateishi, Masami Miyamoto, Moritoshi Kinoshita, Isabelle Stücker, Yoshihiro Mizorogi, Tetsuya Kamataki, Yuki Takahashi, Shinichi Kobayashi, Marie-Anne Loriot, Noritaka Ariyoshi, Satoshi Daigo, Yuri Umetsu, Philippe Beaune
Publikováno v:
Pharmacogenetics. 10(8)
During the course of investigating the frequency of a CYP2A6 whole deletion-type polymorphism (CYP2A6 * 4C) in Japanese, an unexpectedly large population of heterozygotes for CYP2A6 * 4C and the wild-type (CYP2A6 * 1A) was found. Cloning of a cDNA en
Autor:
Jun-Tack Kwon, Fred F. Kadlubar, Philippe Beaune, Yuki Takahashi, Tetsuya Kamataki, Satoshi Daigo, Rashimi Shinha, Noritaka Ariyoshi, Tsuyoshi Yokoi, Ken-ichi Nunoya, Masami Miyamoto, Kanzo Kimura, Yuri Umetsu
Publikováno v:
Drug Metabolism and Pharmacokinetics. 14:100-101
CYP2A6 is known as an enzyme responsible for the metabolism of coumarin. As its toxicological significance, aflatoxin B1 and NNK are metabolically activated by this CYP to mutagens. In our recent studies, we found that a newly developed drug, SM-1250