Výsledky vyhledávání - "Yuri Tsuruya"

Population Pharmacokinetics, Exposure–Safety, and Probability of Target Attainment Analyses for Isavuconazole in Japanese Patients With Deep‐Seated Mycoses

Autor: Shinichiro Shirae, Yuri Tsuruya, Tomohito Kozaki, Junnosuke Mizuhata, Atsushi Ose

Publikováno v: The Journal of Clinical Pharmacology. 63:704-714

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::386d91f62260dcab05e26202a5fa10ef
https://doi.org/10.1002/jcph.2212

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Different Involvement of OAT in Renal Disposition of Oral Anticoagulants Rivaroxaban, Dabigatran, and Apixaban

Autor: Ikumi Tamai, Tomoko Kito, Olaf Schaefer, Hisakazu Komori, Yuri Tsuruya, Norio Yamamura, Thomas Ebner, Wataru Kishimoto, Xinying Wang, Hiroyuki Kusuhara, Naoki Ishiguro, Takeo Nakanishi, Sumito Ito, Kouji Ikukawa

Publikováno v: Journal of Pharmaceutical Sciences. 106:2524-2534

This study aimed to investigate the interactions of 3 anticoagulants, rivaroxaban, apixaban, and dabigatran, with 5 human solute carrier transporters, hOAT1, hOAT3, hOCT2, hOATP1B1, and hOATP1B3. Apixaban inhibited hOAT3, hOATP1B1, and hOATP1B3, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a75ad10a6ea7c4543619674f092469
https://doi.org/10.1016/j.xphs.2017.04.044

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Investigation of Endogenous Compounds Applicable to Drug–Drug Interaction Studies Involving the Renal Organic Anion Transporters, OAT1 and OAT3, in Humans

Autor: Kazuya Maeda, Yuri Tsuruya, Koji Kato, Yuji Kumagai, Hiroyuki Kusuhara, Yuichi Sugiyama, Yuichiro Imamura, Yamato Sano

Publikováno v: Drug Metabolism and Disposition. 44:1925-1933

This study was a comprehensive analysis of metabolites in plasma and urine specimens from subjects who received probenecid, a potent inhibitor of renal organic anion transporters (OATs). Taurine and glycochenodeoxycholate sulfate (GCDCA-S) could be i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474a3a2f05906c65dd43c76e44c28cec
https://doi.org/10.1124/dmd.116.071472

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6β-Hydroxycortisol Is an Endogenous Probe for Evaluation of Drug–Drug Interactions Involving a Multispecific Renal Organic Anion Transporter, OAT3/SLC22A8, in Healthy Subjects

Autor: Yuri Tsuruya, Noriko Okudaira, Hiroyuki Kusuhara, Yuji Kumagai, Dominik Heer, Atsushi Kurihara, Nobuyuki Murayama, Yuichiro Imamura, Kazuya Maeda, Katja Damme, Yuichi Sugiyama, Takashi Izumi

Publikováno v: Drug Metabolism and Disposition. 42:685-694

6β-Hydroxycortisol (6β-OHF) is a substrate of the organic anion transporter 3 (OAT3) and the multidrug and toxin extrusion proteins MATE1 and MATE-2K in the corresponding cDNA-transfected cells. This study aimed to examine the contribution of OAT3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeea5292a162acecf988ba396fbd7e57
https://doi.org/10.1124/dmd.113.055475

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Epigenetic Regulation of Organic Anion Transporting Polypeptide 1B3 in Cancer Cell Lines

Autor: Sotaro Naoi, Hiroyuki Kusuhara, Yuri Tsuruya, Sho Nishida, Yuichi Sugiyama, Ryota Kikuchi, Satoki Imai

Publikováno v: Pharmaceutical Research. 30:2880-2890

The expression of a multispecific organic anion transporter, OATP1B3/SLCO1B3, is associated with clinical prognosis and survival of cancer cells. The aims of present study were to investigate the involvement of epigenetic regulation in mRNA expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3261b3d6c7c15ea5f4e8a8719fcc3f8d
https://doi.org/10.1007/s11095-013-1117-1

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