Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Yuri P. Rubtsov"'
Autor:
Yakov A. Lomakin, Leyla A. Ovchinnikova, Stanislav S. Terekhov, Samir S. Dzhelad, Igor Yaroshevich, Ilgar Mamedov, Anastasia Smirnova, Tatiana Grigoreva, Igor E. Eliseev, Ioanna N. Filimonova, Yuliana A. Mokrushina, Victoria Abrikosova, Maria P. Rubtsova, Nikita N. Kostin, Maria A. Simonova, Tatiana V. Bobik, Natalia L. Aleshenko, Alexander I. Alekhin, Vitali M. Boitsov, Hongkai Zhang, Ivan V. Smirnov, Yuri P. Rubtsov, Alexander G. Gabibov
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Identifying high-affinity antibodies in human serum is challenging due to extremely low number of circulating B cells specific to the desired antigens. Delays caused by a lack of information on the immunogenic proteins of viral origin hamper
Externí odkaz:
https://doaj.org/article/9a1b2eaaa96441b3b3acb5378dc413ce
Autor:
Alexey V. Stepanov, Roman S. Kalinin, Victoria O. Shipunova, Ding Zhang, Jia Xie, Yuri P. Rubtsov, Valeria M. Ukrainskaya, Alexey Schulga, Elena V. Konovalova, Dmitry V. Volkov, Igor A. Yaroshevich, Anastasiia M. Moysenovich, Alexey A. Belogurov, Hongkai Zhang, Georgij B. Telegin, Alexandr S. Chernov, Mikhail A. Maschan, Stanislav S. Terekhov, Peng Wu, Sergey M. Deyev, Richard A. Lerner, Alexander G. Gabibov, Sidney Altman
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(46)
The development of chimeric antigen receptor (CAR) T cell therapy has become a critical milestone in modern oncotherapy. Despite the remarkable in vitro effectiveness, the problem of safety and efficacy of CAR T cell therapy against solid tumors is c
Autor:
Tatiana V. Radaeva, Yana Serdyuk, Daniar Diykanov, Alexander A Nikolaev, Tatiana A. Nenasheva, Nikolai Adrianov, Leonid P. Nezlin, Irina Bocharova, Irina V. Lyadova, Anna Sukhanova, Alexander Panteleev, Yuri P. Rubtsov, Evgenii Tcyganov
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178983 (2017)
PLoS ONE
PLoS ONE
Mesenchymal stromal cells (MSC) have strong immunomodulatory properties and therefore can be used to control inflammation and tissue damage. It was suggested recently that MSC injections can be used to treat multi-drug resistant tuberculosis (TB). Ho
Autor:
Rachel E. Niec, Christophe Benoist, Yuri P. Rubtsov, Jaime Darce, Alexander Y. Rudensky, Diane Mathis, Li Li, Steven Z. Josefowicz
Publikováno v:
Science. 329:1667-1671
Self-Renewing T Cells The homeostasis of cell populations within an organism can be achieved through a variety of mechanisms, including the differentiation of precursor populations, self-renewal of terminally differentiated cells, or by programming c
Autor:
Yuri P. Rubtsov, Alexander Y. Rudensky
Publikováno v:
Nature Reviews Immunology. 7:443-453
In the immune system, transforming growth factor-beta (TGFbeta) affects multiple cell lineages by either promoting or opposing their differentiation, survival and proliferation. Understanding the cellular mechanisms of TGFbeta-mediated regulation is
Autor:
Sergey Melnikov, Ruben N. Karapetian, Irina S. Abaeva, Yuri P. Rubtsov, Erich E. Wanker, Grigoriy S. Filonov, Nina V. Chichkova, Andrey B. Vartapetian, Ulrich Schneider, Alexandra G. Evstafieva, Elena A Sukhacheva
Publikováno v:
Molecular and Cellular Biology. 25:1089-1099
Animal cells counteract oxidative stress and electrophilic attack through coordinated expression of a set of detoxifying and antioxidant enzyme genes mediated by transcription factor Nrf2. In unstressed cells, Nrf2 appears to be sequestered in the cy
Autor:
Ruben N. Karapetian, Alexandra G. Evstafieva, Vitaliy R. Shakulov, Elena A Sukhacheva, Andrey B. Vartapetian, Nadezda A Efimova, Tatyana V Fateeva, Yuri P. Rubtsov
Publikováno v:
Journal of Immunological Methods. 266:185-196
To overcome poor immunogenicity of prothymosin alpha, a small and highly acidic nuclear protein involved in cell proliferation, production of anti-prothymosin alpha antibodies in mice immunized with free human prothymosin alpha, with prothymosin alph
Autor:
Vitaliy R. Shakulov, Nina V. Chichkova, Andrey B. Vartapetian, Yuri P. Rubtsov, Ivan A. Vorobjev
Publikováno v:
Biochemical and Biophysical Research Communications. 274:548-552
A proliferation-related human protein prothymosin alpha displays exclusively nuclear localization when produced in human and Saccharomyces cerevisiae cells, whereas its isolated bipartite NLS confers nuclear targeting of the GFP reporter in human but
Autor:
Yuelei Shen, Mark M.W. Chong, Gabriel D. Victora, Ivaylo I. Ivanov, Roy Min, Yuri P. Rubtsov, Liang Zhou, Alexander Y. Rudensky, Jianguang Du, Steven F. Ziegler, Jared E. Lopes, Dan R. Littman
Publikováno v:
Nature. 453(7192)
T helper cells that produce IL-17 (T(H)17 cells) promote autoimmunity in mice and have been implicated in the pathogenesis of human inflammatory diseases. At mucosal surfaces, T(H)17 cells are thought to protect the host from infection, whereas regul
Autor:
Gertrude K S Chiang, Emil Y. Chi, Xin Ye, Alan G. Singer, Alexander Y. Rudensky, Luca Castelli, Yuri P. Rubtsov, Michael H. Gelb, James G. Bollinger, William R. Henderson, Ying Tzang Tien, Timo J. Nevalainen
Publikováno v:
The Journal of Experimental Medicine
Arachidonic acid metabolites, the eicosanoids, are key mediators of allergen-induced airway inflammation and remodeling in asthma. The availability of free arachidonate in cells for subsequent eicosanoid biosynthesis is controlled by phospholipase A(