Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Yuri Nedialkov"'
Autor:
Philipp K Zuber, Irina Artsimovitch, Monali NandyMazumdar, Zhaokun Liu, Yuri Nedialkov, Kristian Schweimer, Paul Rösch, Stefan H Knauer
Publikováno v:
eLife, Vol 7 (2018)
RfaH, a transcription regulator of the universally conserved NusG/Spt5 family, utilizes a unique mode of recruitment to elongating RNA polymerase to activate virulence genes. RfaH function depends critically on an ops sequence, an exemplar of a conse
Externí odkaz:
https://doaj.org/article/089d9824950546ed851f4a74b20b0339
Autor:
Yuri Nedialkov, Ruben Abagyan, Dmitri Svetlov, David A. Rosen, Da Shi, Irina Artsimovitch, Joy Twentyman
Publikováno v:
Molecular microbiology, vol 110, iss 1
RfaH is required for virulence in several Gram-negative pathogens including Escherichia coli and Klebsiella pneumoniae. Through direct interactions with RNA polymerase (RNAP) and ribosome, RfaH activates the expression of capsule, cell wall and pilus
Publikováno v:
Molecular Microbiology. 109:445-457
Universally conserved NusG/Spt5 factors reduce RNA polymerase pausing and arrest. In a widely accepted model, these proteins bridge the RNA polymerase clamp and lobe domains across the DNA channel, inhibiting the clamp opening to promote pause-free R
Autor:
Yuri Nedialkov, Monali NandyMazumdar, Irina Artsimovitch, Anastasia Sevostyanova, Dmitri Svetlov, Georgiy A. Belogurov
Publikováno v:
Proceedings of the National Academy of Sciences. 113:14994-14999
Upon RNA polymerase (RNAP) binding to a promoter, the σ factor initiates DNA strand separation and captures the melted nontemplate DNA, whereas the core enzyme establishes interactions with the duplex DNA in front of the active site that stabilize i
Unlike transcription initiation and termination, which have easily discernable signals such as promoters and terminators, elongation is regulated through a dynamic network involving RNA/DNA pause signals and states- rather than sequence-specific prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fb187640dd457a5ae5a2c6184db688e6
https://europepmc.org/articles/PMC6173972/
https://europepmc.org/articles/PMC6173972/
Autor:
Julia R. Widom, Nils G. Walter, Yuri Nedialkov, Irina Artsimovitch, Ryan L. Hayes, Victoria Rai, Charles L. Brooks
Publikováno v:
Molecular cell, vol 72, iss 3
Numerous classes of riboswitches have been found to regulate bacterial gene expression in response to physiological cues, offering new paths to anti-bacterial drugs. As common studies of isolated riboswitches lack the functional context of the transc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6ae20c63caaeec452383a1be87ad11a
https://doi.org/10.1101/350447
https://doi.org/10.1101/350447
Autor:
Jin Young Kang, Rachel A. Mooney, Jason Saba, Yuri Nedialkov, Robert Landick, Irina Artsimovitch, Seth A. Darst, Tatiana V. Mishanina
SUMMARYNusG/RfaH/Spt5 transcription elongation factors are the only transcription regulators conserved across all life. In bacteria, NusG regulates RNA polymerase (RNAP) elongation complexes (ECs) across most genes, enhancing elongation by suppressin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e6f5f50c3dfa08f5ef791e89ee43f9
https://doi.org/10.1101/324400
https://doi.org/10.1101/324400
Autor:
Stefan H. Knauer, Yuri Nedialkov, Monali NandyMazumdar, Philipp K. Zuber, Irina Artsimovitch, Zhaokun Liu, Paul Rösch, Kristian Schweimer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a23243213095a1c59a6121cc3b66f39
https://doi.org/10.7554/elife.36349.022
https://doi.org/10.7554/elife.36349.022
Autor:
Jason Saba, Tatiana V. Mishanina, Yuri Nedialkov, Rachel A. Mooney, Jin Young Kang, Seth A. Darst, Irina Artsimovitch, Robert Landick
Publikováno v:
Cell. 173(7)
Summary NusG/RfaH/Spt5 transcription elongation factors are the only transcription regulators conserved across all life. Bacterial NusG regulates RNA polymerase (RNAP) elongation complexes (ECs) across most genes, enhancing elongation by suppressing
Publikováno v:
Nucleic Acids Research
RNA folding during transcription directs an order of folding that can determine RNA structure and function. However, the experimental study of cotranscriptional RNA folding has been limited by the lack of easily approachable methods that can interrog