Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Yuri N, Utkin"'
Autor:
Peter V. Dubovskii, Yuri N. Utkin
Publikováno v:
Toxins, Vol 16, Iss 6, p 262 (2024)
Cytotoxins (CTs) are three-finger membrane-active toxins present mainly in cobra venom. Our analysis of the available CT amino acid sequences, literature data on their membrane activity, and conformational equilibria in aqueous solution and detergent
Externí odkaz:
https://doaj.org/article/62a207b921f24a71a16ff71d1fad7d15
Autor:
Alexey V. Osipov, Elena G. Cheremnykh, Rustam H. Ziganshin, Vladislav G. Starkov, Trang Thuy Thi Nguyen, Khoa Cuu Nguyen, Dung Tien Le, Anh Ngoc Hoang, Victor I. Tsetlin, Yuri N. Utkin
Publikováno v:
Biomedicines, Vol 11, Iss 4, p 1115 (2023)
Protozoal infections are a world-wide problem. The toxicity and somewhat low effectiveness of the existing drugs require the search for new ways of protozoa suppression. Snake venom contains structurally diverse components manifesting antiprotozoal a
Externí odkaz:
https://doaj.org/article/7a177c847780467ab6b7d0f85c76a908
Autor:
Alexey S. Averin, Mikhail V. Goltyaev, Tatyana V. Andreeva, Vladislav G. Starkov, Victor I. Tsetlin, Yuri N. Utkin
Publikováno v:
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 28 (2022)
Abstract Background: The cardiovascular system is one of the first systems to be affected by snake toxins; but not many toxins exert a direct effect on the heart. Cobra venom cardiotoxins are among those few toxins that attack the heart. Although the
Externí odkaz:
https://doaj.org/article/0c4ab6941d1a4a2297d3eac6f46ecb5b
Publikováno v:
Toxins, Vol 14, Iss 12, p 839 (2022)
Cytotoxins (CTXs), an essential class of the non-enzymatic three-finger toxin family, are ubiquitously present in cobra venoms. These low-molecular-mass toxins, contributing to about 40 to 60% of the cobra venom proteome, play a significant role in c
Externí odkaz:
https://doaj.org/article/3b6ec986b36647409c859070f62a77f8
Autor:
Peter V. Dubovskii, Anastasia A. Ignatova, Anna S. Alekseeva, Vladislav G. Starkov, Ivan A. Boldyrev, Alexey V. Feofanov, Yuri N. Utkin
Publikováno v:
Toxins, Vol 15, Iss 1, p 6 (2022)
In aqueous solutions, cobra cytotoxins (CTX), three-finger folded proteins, exhibit conformational equilibrium between conformers with either cis or trans peptide bonds in the N-terminal loop (loop-I). The equilibrium is shifted to the cis form in to
Externí odkaz:
https://doaj.org/article/e5bc9fea67aa413bbaee97dbd23a3a0f
Autor:
Igor E. Kasheverov, Alexey I. Kuzmenkov, Denis S. Kudryavtsev, Ivan S. Chudetskiy, Irina V. Shelukhina, Evgeny P. Barykin, Igor A. Ivanov, Andrei E. Siniavin, Rustam H. Ziganshin, Mikhail S. Baranov, Victor I. Tsetlin, Alexander A. Vassilevski, Yuri N. Utkin
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Fluorescence can be exploited to monitor intermolecular interactions in real time and at a resolution up to a single molecule. It is a method of choice to study ligand-receptor interactions. However, at least one of the interacting molecules should p
Externí odkaz:
https://doaj.org/article/8df2465348d643aa93dc27978d775e2c
Autor:
Zhijian Cao, Jing-Lin Wang, Patrick Michael McNutt, Yuri N. Utkin, Delavar Shahbazzadeh, Heike Wulff, Hervé Kovacic, Jean-Marc Sabatier
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/cdda6224d1634d0eb48bcbc5c9538b3a
Autor:
Peter V. Dubovskii, Kira M. Dubova, Gleb Bourenkov, Vladislav G. Starkov, Anastasia G. Konshina, Roman G. Efremov, Yuri N. Utkin, Valeriya R. Samygina
Publikováno v:
Toxins, Vol 14, Iss 2, p 149 (2022)
Cobra cytotoxins (CTs) belong to the three-fingered protein family and possess membrane activity. Here, we studied cytotoxin 13 from Naja naja cobra venom (CT13Nn). For the first time, a spatial model of CT13Nn with both “water” and “membrane
Externí odkaz:
https://doaj.org/article/0070f421d8124d2aaff9386ae360706a
Publikováno v:
Toxins, Vol 14, Iss 2, p 88 (2022)
Cardiotoxins (CaTxs) are a group of snake toxins that affect the cardiovascular system (CVS). Two types (S and P) of CaTxs are known, but the exact differences in the effects of these types on CVS have not been thoroughly studied. We investigated cel
Externí odkaz:
https://doaj.org/article/b683c845f2344bb1a6bcad66c52a37df
Autor:
Thien V. Tran, Andrei E. Siniavin, Anh N. Hoang, My T.T. Le, Chuong D. Pham, Trung V. Phung, Khoa C. Nguyen, Rustam H. Ziganshin, Victor I. Tsetlin, Ching-Feng Weng, Yuri N. Utkin
Publikováno v:
PeerJ, Vol 7, p e8055 (2019)
Background Snake venoms are the complex mixtures of different compounds manifesting a wide array of biological activities. The venoms of kraits (genus Bungarus, family Elapidae) induce mainly neurological symptoms; however, these venoms show a cytoto
Externí odkaz:
https://doaj.org/article/1af9fd3812aa4ccc99a81f5fd7d2a2ab