Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Yuri Motorin"'
Autor:
Samia Quaiyum, Jingjing Sun, Virginie Marchand, Guangxin Sun, Colbie J. Reed, Yuri Motorin, Peter C. Dedon, Michael F. Minnick, Valérie de Crécy-Lagard
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Transfer RNA (tRNA) modifications play a crucial role in maintaining translational fidelity and efficiency, and they may function as regulatory elements in stress response and virulence. Despite their pivotal roles, a comprehensive mapping of tRNA mo
Externí odkaz:
https://doaj.org/article/2b175cc03c7547cbb00c234e3ce585c6
Autor:
Raquel García-Vílchez, Ana M. Añazco-Guenkova, Sabine Dietmann, Judith López, Virginia Morón-Calvente, Silvia D’Ambrosi, Paz Nombela, Kepa Zamacola, Isabel Mendizabal, Saioa García-Longarte, Amaia Zabala-Letona, Ianire Astobiza, Sonia Fernández, Alejandro Paniagua, Borja Miguel-López, Virginie Marchand, Diego Alonso-López, Angelika Merkel, Ignacio García-Tuñón, Aitziber Ugalde-Olano, Ana Loizaga-Iriarte, Isabel Lacasa-Viscasillas, Miguel Unda, Mikel Azkargorta, Félix Elortza, Laura Bárcena, Monika Gonzalez-Lopez, Ana M. Aransay, Tomás Di Domenico, Manuel A. Sánchez-Martín, Javier De Las Rivas, Sònia Guil, Yuri Motorin, Mark Helm, Pier Paolo Pandolfi, Arkaitz Carracedo, Sandra Blanco
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-36 (2023)
Abstract Newly growing evidence highlights the essential role that epitranscriptomic marks play in the development of many cancers; however, little is known about the role and implications of altered epitranscriptome deposition in prostate cancer. He
Externí odkaz:
https://doaj.org/article/23776f080b2242829817059af1fa8867
Autor:
Guus G. H. van den Akker, Alzbeta Chabronova, Bas A. C. Housmans, Laura van der Vloet, Don A. M. Surtel, Andy Cremers, Virginie Marchand, Yuri Motorin, Marjolein M. J. Caron, Mandy J. Peffers, Tim J. M. Welting
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 5031 (2024)
Alterations in cell fate are often attributed to (epigenetic) regulation of gene expression. An emerging paradigm focuses on specialized ribosomes within a cell. However, little evidence exists for the dynamic regulation of ribosome composition and f
Externí odkaz:
https://doaj.org/article/d7d9f5d831d74ac3ad9db64e42e3112d
Autor:
Kishor Gawade, Patrycja Plewka, Sophia J. Häfner, Anders H. Lund, Virginie Marchand, Yuri Motorin, Michal W. Szczesniak, Katarzyna D. Raczynska
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract FUS is a multifunctional protein involved in many aspects of RNA metabolism, including transcription, splicing, translation, miRNA processing, and replication-dependent histone gene expression. In this work, we show that FUS depletion result
Externí odkaz:
https://doaj.org/article/305ea8adfd974367b7a37f4dd385f3f3
Autor:
Florian Pichot, Marion C. Hogg, Virginie Marchand, Valérie Bourguignon, Elisabeth Jirström, Cliona Farrell, Hesham A. Gibriel, Jochen H.M. Prehn, Yuri Motorin, Mark Helm
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 401-417 (2023)
Modification of tRNA is an integral part of the epitranscriptome with a particularly pronounced potential to generate diversity in RNA expression. Eukaryotic tRNA contains modifications in up to 20% of their nucleotides, but not all sites are always
Externí odkaz:
https://doaj.org/article/5444ab864f174edf9600ecf2715a0d80
Autor:
Alzbeta Chabronova, Guus van den Akker, Bas A. C. Housmans, Marjolein M. J. Caron, Andy Cremers, Don A. M. Surtel, Mandy J. Peffers, Lodewijk W. van Rhijn, Virginie Marchand, Yuri Motorin, Tim J. M. Welting
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12578 (2023)
Eukaryotic ribosomes are complex molecular nanomachines translating genetic information from mRNAs into proteins. There is natural heterogeneity in ribosome composition. The pseudouridylation (ψ) of ribosomal RNAs (rRNAs) is one of the key sources o
Externí odkaz:
https://doaj.org/article/f79530137c2145ee8eaffd0161a54d5d
Autor:
Sébastien Relier, Julie Ripoll, Hélène Guillorit, Amandine Amalric, Cyrinne Achour, Florence Boissière, Jérôme Vialaret, Aurore Attina, Françoise Debart, Armelle Choquet, Françoise Macari, Virginie Marchand, Yuri Motorin, Emmanuelle Samalin, Jean-Jacques Vasseur, Julie Pannequin, Francesca Aguilo, Evelyne Lopez-Crapez, Christophe Hirtz, Eric Rivals, Amandine Bastide, Alexandre David
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The demethylase FTO was shown to remove on N6-methyladenosine (m6A) and N6, 2’-O-dimethyladenosine (m6Am) modifications on RNAs. Here the authors show that FTO impedes cancer stem cell-like abilities in colorectal cancer cells through its m6Am deme
Externí odkaz:
https://doaj.org/article/9446244d632a4b05a389d98461a70dd7
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Post transcriptional modification of RNAs represents an important layer of gene regulation. Here the authors describe NAIL-MS—a method for monoisotopic RNA labeling in cell culture—demonstrating its capabilities by analyzing the modification kine
Externí odkaz:
https://doaj.org/article/6576875b198b477bb54b337f7ff87c65
Autor:
Jonathan Delhermite, Lionel Tafforeau, Sunny Sharma, Virginie Marchand, Ludivine Wacheul, Ruben Lattuca, Simon Desiderio, Yuri Motorin, Eric Bellefroid, Denis L J Lafontaine
Publikováno v:
PLoS Genetics, Vol 18, Iss 1, p e1010012 (2022)
Ribosomes are essential nanomachines responsible for protein production. Although ribosomes are present in every living cell, ribosome biogenesis dysfunction diseases, called ribosomopathies, impact particular tissues specifically. Here, we evaluate
Externí odkaz:
https://doaj.org/article/3d415ccefde94a13a897dc588394fa83
Autor:
Carole Trzaska, Séverine Amand, Christine Bailly, Catherine Leroy, Virginie Marchand, Evelyne Duvernois-Berthet, Jean-Michel Saliou, Hana Benhabiles, Elisabeth Werkmeister, Thierry Chassat, Romain Guilbert, David Hannebique, Anthony Mouray, Marie-Christine Copin, Pierre-Arthur Moreau, Eric Adriaenssens, Andreas Kulozik, Eric Westhof, David Tulasne, Yuri Motorin, Sylvie Rebuffat, Fabrice Lejeune
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nonsense mutations can be corrected by several molecules that activate readthrough of premature termination codon. Here, the authors report that 2,6-diaminopurine efficiently corrects UGA nonsense mutations with no significant toxicity.
Externí odkaz:
https://doaj.org/article/970f33637b174d7ca2db00d47c85ff08