Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Yuri Kosinsky"'
Publikováno v:
Frontiers in Applied Mathematics and Statistics, Vol 8 (2022)
Anti CTLA-4 therapy is aimed at blocking the Cytotoxic T-lymphocyte antigen-4 (CTLA-4), a key cancer immunity cycle checkpoint. The mechanism of action of CTLA-4 may be described as a dynamic competition for the B7 ligand which, subsequently, interfe
Externí odkaz:
https://doaj.org/article/40dafde082c041508077a8aed1990c1e
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 2 (2022)
ABSTRACT The SARS-CoV-2 coronavirus, which causes COVID-19, uses a viral surface spike protein for host cell entry and the human cell-surface transmembrane serine protease, TMPRSS2, to process the spike protein. Camostat mesylate, an orally available
Externí odkaz:
https://doaj.org/article/4d66e7352a4f4b37bcdd65927cfcc350
Autor:
Gabriel Helmlinger, Victor Sokolov, Kirill Peskov, Karen M. Hallow, Yuri Kosinsky, Veronika Voronova, Lulu Chu, Tatiana Yakovleva, Ivan Azarov, Daniel Kaschek, Artem Dolgun, Henning Schmidt, David W. Boulton, Robert C. Penland
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 6, Pp 380-395 (2019)
Quantitative systems pharmacology (QSP), a mechanistically oriented form of drug and disease modeling, seeks to address a diverse set of problems in the discovery and development of therapies. These problems bring a considerable amount of variability
Externí odkaz:
https://doaj.org/article/0bc86cacff10421bbe8ac64b3a5e719b
Autor:
Veronika Voronova, Kirill Peskov, Yuri Kosinsky, Gabriel Helmlinger, Lulu Chu, Alexandra Borodovsky, Richard Woessner, Kris Sachsenmeier, Wenlin Shao, Rakesh Kumar, Gayle Pouliot, Melinda Merchant, Holly Kimko, Ganesh Mugundu
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundAdenosine receptor type 2 (A2AR) inhibitor, AZD4635, has been shown to reduce immunosuppressive adenosine effects within the tumor microenvironment (TME) and to enhance the efficacy of checkpoint inhibitors across various syngeneic models.
Externí odkaz:
https://doaj.org/article/1a1c06171901426c87250762be86e987
Autor:
Boris Shulgin, Yuri Kosinsky, Andrey Omelchenko, Lulu Chu, Ganesh Mugundu, Sergey Aksenov, Rodrigo Pimentel, Garrett DeYulia, Geoffrey Kim, Kirill Peskov, Gabriel Helmlinger
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Programmed cell death-1 (PD-1) and/or cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) immune checkpoint inhibitor (ICI) treatments are associated with adverse events (AEs), which may be dependent on ICI dose. Applying a model-based meta-analys
Externí odkaz:
https://doaj.org/article/ba6cbaee68e24581a253dccc7dd7c5d1
Autor:
Yuri Kosinsky, Simon J. Dovedi, Kirill Peskov, Veronika Voronova, Lulu Chu, Helen Tomkinson, Nidal Al-Huniti, Donald R. Stanski, Gabriel Helmlinger
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-15 (2018)
Abstract Background Numerous oncology combination therapies involving modulators of the cancer immune cycle are being developed, yet quantitative simulation models predictive of outcome are lacking. We here present a model-based analysis of tumor siz
Externí odkaz:
https://doaj.org/article/6864f2475f1e4703b3c1be9f5fbfb02a
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The adaptive immune response is initiated in lymph nodes by contact between antigen-bearing dendritic cells (DCs) and antigen-specific T cells. A selected number of naïve T cells that recognize a specific antigen may proliferate into expanded clones
Externí odkaz:
https://doaj.org/article/1c8fd8aef79a41ddb1e368c649b8bc4c
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Following the approval, in recent years, of the first immune checkpoint inhibitor, there has been an explosion in the development of immuno-modulating pharmacological modalities for the treatment of various cancers. From the discovery phase to late-s
Externí odkaz:
https://doaj.org/article/fd66554c074643cfab87124519b5cf8e
Publikováno v:
Pharmaceuticals, Vol 13, Iss 10, p 265 (2020)
The kinetic model of Prostaglandin H Synthase-1 (PGHS-1) was developed to investigate its complex network kinetics and non-steroidal anti-inflammatory drugs (NSAIDs) efficacy in different in vitro and in vivo conditions. To correctly describe the com
Externí odkaz:
https://doaj.org/article/33718472102a40cbab3dfeb0e2f1eaa5
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149154 (2016)
Enhancement or inhibition of cytokine signaling and corresponding immune cells responses are critical factors in various disease treatments. Cytokine signaling may be inhibited by cytokine-neutralizing antibodies (CNAs), which prevents further activa
Externí odkaz:
https://doaj.org/article/d0302b0b4d4b49f4aee7e68ff46fbc84