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Autor:
Yuri E. Shapiro, Sergei A. Andronati, Anatoly A. Mazurov, T. A. Voronina, Tamara I. Korotenko, Nikolai I. Sokolenko, Alexei I. Dyadenko, Vitalii Ya. Gorbatyuk
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2595-2600
A new cognitive enhancer (8S, 10aS)-8-carbamoyl-1,2,3,6,7,8,9,10a-octahydro-5H,10H-pyrrolo[1,2-a][1,4]diazocin-5,10-dione ( 3 ) has been designed based on the approach consisting of two steps: 1) “obligatory” replacement of histidine with glutami