α-Latrotoxin Tetramers Spontaneously Form Two-Dimensional Crystals in Solution and Coordinated Multi-Pore Assemblies in Biological Membranes

Autor: Alexis Rohou, Edward P. Morris, Julia Makarova, Alexander G. Tonevitsky, Yuri A. Ushkaryov

Publikováno v: Toxins, Vol 16, Iss 6, p 248 (2024)

α-Latrotoxin (α-LTX) was found to form two-dimensional (2D) monolayer arrays in solution at relatively low concentrations (0.1 mg/mL), with the toxin tetramer constituting a unit cell. The crystals were imaged using cryogenic electron microscopy (c

Externí odkaz: https://doaj.org/article/811db7b37d7441be8e8fab2b656efc0d

The Tim-3-Galectin-9 Pathway and Its Regulatory Mechanisms in Human Breast Cancer

Autor: Inna M. Yasinska, Svetlana S. Sakhnevych, Ludmila Pavlova, Anette Teo Hansen Selnø, Ana Maria Teuscher Abeleira, Ouafa Benlaouer, Isabel Gonçalves Silva, Marianne Mosimann, Luca Varani, Marco Bardelli, Rohanah Hussain, Giuliano Siligardi, Dietmar Cholewa, Steffen M. Berger, Bernhard F. Gibbs, Yuri A. Ushkaryov, Elizaveta Fasler-Kan, Elena Klenova, Vadim V. Sumbayev

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Human cancer cells operate a variety of effective molecular and signaling mechanisms which allow them to escape host immune surveillance and thus progress the disease. We have recently reported that the immune receptor Tim-3 and its natural ligand ga

Externí odkaz: https://doaj.org/article/83b5108e523d4c67ad0de9fa49513b57

Proteolytically released Lasso/teneurin-2 induces axonal attraction by interacting with latrophilin-1 on axonal growth cones

Autor: Nickolai V Vysokov, John-Paul Silva, Vera G Lelianova, Jason Suckling, John Cassidy, Jennifer K Blackburn, Natalia Yankova, Mustafa BA Djamgoz, Serguei V Kozlov, Alexander G Tonevitsky, Yuri A Ushkaryov

Publikováno v: eLife, Vol 7 (2018)

A presynaptic adhesion G-protein-coupled receptor, latrophilin-1, and a postsynaptic transmembrane protein, Lasso/teneurin-2, are implicated in trans-synaptic interaction that contributes to synapse formation. Surprisingly, during neuronal developmen

Externí odkaz: https://doaj.org/article/e3ab38e5ab3145c8b2d8316c81bfd8a3

The expanding functional roles and signaling mechanisms of adhesion G protein-coupled receptors

Autor: Simone Prömel, Swati Srivastava, Nariman Balenga, Demet Araç, Hee Yong Kim, Nicole Scholz, Uwe Wolfrum, Yuri A. Ushkaryov, Rory K. Morgan, Randy A. Hall, Mario Vallon, James P. Bridges, Deva Krupakar Kusuluri, Gabriela Aust, Benoit Vanhollebeke, Ryan S. Gray, Antony A. Boucard, Xianhua Piao, Kelly R. Monk, Katherine Leon, Amit Mogha, Erwin G. Van Meir, Maike D. Glitsch, Cheng-Chih Hsiao, Kevin M. Wright, Ines Liebscher, Garret R. Anderson, Alexander Bernd Knierim, Caroline J. Formstone, Felix B. Engel, Kimberley F. Tolias, Doreen Thor

Publikováno v: Annals of the New York Academy of Sciences, vol 1456, iss 1
Annals of the New York Academy of Sciences, 1456(1), 5-25. Wiley-Blackwell
Ann N Y Acad Sci
Annals of the New York Academy of Sciences

The adhesion class of G protein-coupled receptors (GPCRs) is the second largest family of GPCRs (33 members in humans). Adhesion GPCRs (aGPCRs) are defined by a large extracellular N-terminal region that is linked to a C-terminal seven transmembrane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a5f5f51f91694384a721cf3709b948
https://escholarship.org/uc/item/9j92p473

Adhesion Class GPCRs (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Autor: Torsten Schöneberg, Diana Le Duc, Breanne L. Harty, Christiane Kirchhoff, Simone Prömel, Heike Cappallo-Obermann, Demet Arac-Ozkan, Xianhua Piao, Gabriela Aust, Lei Xu, Helgi B. Schiöth, Hsi-Hsien Lin, Kathleen Singer, Barbara Knapp, Uwe Wolfrum, Jörg Hamann, Arunkumar Krishnan, Martin Stacey, Henrike O. Heyne, Tobias Langenhan, David C. Martinelli, Caroline J. Formstone, Yuri A. Ushkaryov, Tom I. Bonner, Kelly Monk

Publikováno v: IUPHAR/BPS Guide to Pharmacology CITE. 2019

Adhesion GPCRs are structurally identified on the basis of a large extracellular region, similar to the Class B GPCR, but which is linked to the 7TM region by a GPCR autoproteolysis-inducing (GAIN) domain [8] containing a GPCR proteolytic site. The N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c6c2fe20a12572da6bb8aa516cf7e48
https://doi.org/10.2218/gtopdb/f17/2019.4