Proteolytically released Lasso/teneurin-2 induces axonal attraction by interacting with latrophilin-1 on axonal growth cones

Autor: Nickolai V Vysokov, John-Paul Silva, Vera G Lelianova, Jason Suckling, John Cassidy, Jennifer K Blackburn, Natalia Yankova, Mustafa BA Djamgoz, Serguei V Kozlov, Alexander G Tonevitsky, Yuri A Ushkaryov

Publikováno v: eLife, Vol 7 (2018)

A presynaptic adhesion G-protein-coupled receptor, latrophilin-1, and a postsynaptic transmembrane protein, Lasso/teneurin-2, are implicated in trans-synaptic interaction that contributes to synapse formation. Surprisingly, during neuronal developmen

Externí odkaz: https://doaj.org/article/e3ab38e5ab3145c8b2d8316c81bfd8a3

The Tim-3-galectin-9 Secretory Pathway is Involved in the Immune Escape of Human Acute Myeloid Leukemia Cells

Autor: Isabel Gonçalves Silva, Inna M. Yasinska, Svetlana S. Sakhnevych, Walter Fiedler, Jasmin Wellbrock, Marco Bardelli, Luca Varani, Rohanah Hussain, Giuliano Siligardi, Giacomo Ceccone, Steffen M. Berger, Yuri A. Ushkaryov, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev

Publikováno v: EBioMedicine, Vol 22, Iss C, Pp 44-57 (2017)

Acute myeloid leukemia (AML) is a severe and often fatal systemic malignancy. Malignant cells are capable of escaping host immune surveillance by inactivating cytotoxic lymphoid cells. In this work we discovered a fundamental molecular pathway, which

Externí odkaz: https://doaj.org/article/e004d7f74c5c43a19b8c11d1701ce852

Catching Latrophilin With Lasso: A Universal Mechanism for Axonal Attraction and Synapse Formation

Autor: Yuri A. Ushkaryov, Vera Lelianova, Nickolai V. Vysokov

Publikováno v: Frontiers in Neuroscience, Vol 13 (2019)

Latrophilin-1 (LPHN1) was isolated as the main high-affinity receptor for α-latrotoxin from black widow spider venom, a powerful presynaptic secretagogue. As an adhesion G-protein-coupled receptor, LPHN1 is cleaved into two fragments, which can beha

Externí odkaz: https://doaj.org/article/b1f301ced6c54d38bdbec057749d0499

The expanding functional roles and signaling mechanisms of adhesion G protein-coupled receptors

Autor: Simone Prömel, Swati Srivastava, Nariman Balenga, Demet Araç, Hee Yong Kim, Nicole Scholz, Uwe Wolfrum, Yuri A. Ushkaryov, Rory K. Morgan, Randy A. Hall, Mario Vallon, James P. Bridges, Deva Krupakar Kusuluri, Gabriela Aust, Benoit Vanhollebeke, Ryan S. Gray, Antony A. Boucard, Xianhua Piao, Kelly R. Monk, Katherine Leon, Amit Mogha, Erwin G. Van Meir, Maike D. Glitsch, Cheng-Chih Hsiao, Kevin M. Wright, Ines Liebscher, Garret R. Anderson, Alexander Bernd Knierim, Caroline J. Formstone, Felix B. Engel, Kimberley F. Tolias, Doreen Thor

Publikováno v: Annals of the New York Academy of Sciences, vol 1456, iss 1
Annals of the New York Academy of Sciences, 1456(1), 5-25. Wiley-Blackwell
Ann N Y Acad Sci
Annals of the New York Academy of Sciences

The adhesion class of G protein-coupled receptors (GPCRs) is the second largest family of GPCRs (33 members in humans). Adhesion GPCRs (aGPCRs) are defined by a large extracellular N-terminal region that is linked to a C-terminal seven transmembrane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a5f5f51f91694384a721cf3709b948
https://escholarship.org/uc/item/9j92p473

Adhesion Class GPCRs (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Autor: Torsten Schöneberg, Diana Le Duc, Breanne L. Harty, Christiane Kirchhoff, Simone Prömel, Heike Cappallo-Obermann, Demet Arac-Ozkan, Xianhua Piao, Gabriela Aust, Lei Xu, Helgi B. Schiöth, Hsi-Hsien Lin, Kathleen Singer, Barbara Knapp, Uwe Wolfrum, Jörg Hamann, Arunkumar Krishnan, Martin Stacey, Henrike O. Heyne, Tobias Langenhan, David C. Martinelli, Caroline J. Formstone, Yuri A. Ushkaryov, Tom I. Bonner, Kelly Monk

Publikováno v: IUPHAR/BPS Guide to Pharmacology CITE. 2019

Adhesion GPCRs are structurally identified on the basis of a large extracellular region, similar to the Class B GPCR, but which is linked to the 7TM region by a GPCR autoproteolysis-inducing (GAIN) domain [8] containing a GPCR proteolytic site. The N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c6c2fe20a12572da6bb8aa516cf7e48
https://doi.org/10.2218/gtopdb/f17/2019.4