Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Yuri, Tolkach"'
Autor:
Sebastian Klein, Yuri Tolkach, Hans Christian Reinhardt, Reinhard Buettner, Alexander Quaas, Doris Helbig
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Pleomorphic dermal sarcomas are infrequent neoplastic skin tumors, manifesting in regions of the skin exposed to ultraviolet radiation. Diagnosing the entity can be challenging and therapeutic options are limited. We analyzed 20 samples of n
Externí odkaz:
https://doaj.org/article/ca774a0e925240db82fb5be795d691b9
Autor:
Carina Kludt, Yuan Wang, Waleed Ahmad, Andrey Bychkov, Junya Fukuoka, Nadine Gaisa, Mark Kühnel, Danny Jonigk, Alexey Pryalukhin, Fabian Mairinger, Franziska Klein, Anne Maria Schultheis, Alexander Seper, Wolfgang Hulla, Johannes Brägelmann, Sebastian Michels, Sebastian Klein, Alexander Quaas, Reinhard Büttner, Yuri Tolkach
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101697- (2024)
Summary: Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors. In this study, we develop a clinically useful computational pathology platform for NSCLC that can be a foundation for multiple downstream applications and provide
Externí odkaz:
https://doaj.org/article/1c9ae39a56f14732bf941542393578b7
Autor:
Okyaz Eminaga, Mahmoud Abbas, Christian Kunder, Yuri Tolkach, Ryan Han, James D. Brooks, Rosalie Nolley, Axel Semjonow, Martin Boegemann, Robert West, Jin Long, Richard E. Fan, Olaf Bettendorf
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-30 (2024)
Abstract Prostate cancer pathology plays a crucial role in clinical management but is time-consuming. Artificial intelligence (AI) shows promise in detecting prostate cancer and grading patterns. We tested an AI-based digital twin of a pathologist, v
Externí odkaz:
https://doaj.org/article/378b253abe26462a92e7ddbdb8d64e5c
Autor:
Andreas H. Scheel, Hannah Lamberty, Yuri Tolkach, Florian Gebauer, Birgid Schoemig-Markiefka, Thomas Zander, Reinhard Buettner, Josef Rueschoff, Christiane Josephine Bruns, Wolfgang Schroeder, Alexander Quaas
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Guidelines regulate how many (tumour-bearing) tissue particles should be sampled during gastric cancer biopsy to obtain representative results in predictive biomarker testing. Little is known about how well these guidelines are applied, how
Externí odkaz:
https://doaj.org/article/3fa29354b4e7437cae6b5f805d6c5c1a
Autor:
Yuri Tolkach, Vlado Ovtcharov, Alexey Pryalukhin, Marie-Lisa Eich, Nadine Therese Gaisa, Martin Braun, Abdukhamid Radzhabov, Alexander Quaas, Peter Hammerer, Ansgar Dellmann, Wolfgang Hulla, Michael C. Haffner, Henning Reis, Ibrahim Fahoum, Iryna Samarska, Artem Borbat, Hoa Pham, Axel Heidenreich, Sebastian Klein, George Netto, Peter Caie, Reinhard Buettner
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-9 (2023)
Abstract Pathologic examination of prostate biopsies is time consuming due to the large number of slides per case. In this retrospective study, we validate a deep learning-based classifier for prostate cancer (PCA) detection and Gleason grading (AI t
Externí odkaz:
https://doaj.org/article/21c0c2f5c021418b81a6adbfc9cf02b8
Autor:
Sebastian Klein, Nora Wuerdemann, Imke Demers, Christopher Kopp, Jennifer Quantius, Arthur Charpentier, Yuri Tolkach, Klaus Brinker, Shachi Jenny Sharma, Julie George, Jochen Hess, Fabian Stögbauer, Martin Lacko, Marijn Struijlaart, Mari F.C.M. van den Hout, Steffen Wagner, Claus Wittekindt, Christine Langer, Christoph Arens, Reinhard Buettner, Alexander Quaas, Hans Christian Reinhardt, Ernst-Jan Speel, Jens Peter Klussmann
Publikováno v:
npj Digital Medicine, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Human Papilloma Virus (HPV)-associated oropharyngeal squamous cell cancer (OPSCC) represents an OPSCC subgroup with an overall good prognosis with a rising incidence in Western countries. Multiple lines of evidence suggest that HPV-associate
Externí odkaz:
https://doaj.org/article/f7d0384c46ef4d72a45339eb8dbc1743
Autor:
Larissa Gundert, Alexander Strick, Felix vonHagen, Doris Schmidt, Niklas Klümper, Yuri Tolkach, Marieta Toma, Glen Kristiansen, Manuel Ritter, Jörg Ellinger
Publikováno v:
BJUI Compass, Vol 2, Iss 6, Pp 402-411 (2021)
Abstract Objectives To investigate the regulation of the N‐6‐methyladenosine (m6A) methyltransferases METTL3, METTL14, WTAP, KIAA1429, and METTL4, referred to as “m6A writers,” in clear cell renal cell carcinoma (ccRCC), and other RCC subtype
Externí odkaz:
https://doaj.org/article/4ca73d20926b4acb80b4b8068223207f
Autor:
Yuri Tolkach, Lisa Marie Wolgast, Alexander Damanakis, Alexey Pryalukhin, Simon Schallenberg, Wolfgang Hulla, Marie-Lisa Eich, Wolfgang Schroeder, Anirban Mukhopadhyay, Moritz Fuchs, Sebastian Klein, Christiane Bruns, Reinhard Büttner, Florian Gebauer, Birgid Schömig-Markiefka, Alexander Quaas
Publikováno v:
The Lancet Digital Health. 5:e265-e275
Publikováno v:
BMC Urology, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background The identification of appropriate biomarkers is essential to support important clinical decisions in patients with prostate cancer. The aim of our study was a systematic bioinformatical analysis of the mRNA expression of all genes
Externí odkaz:
https://doaj.org/article/76700de721df49399f2983c31347efb5
Serum miR-122-5p and miR-206 expression: non-invasive prognostic biomarkers for renal cell carcinoma
Autor:
Frauke G. Heinemann, Yuri Tolkach, Mario Deng, Doris Schmidt, Sven Perner, Glen Kristiansen, Stefan C. Müller, Jörg Ellinger
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-9 (2018)
Abstract Background MicroRNAs (miRNA) play a relevant role in carcinogenesis, cancer progression, invasion, and metastasis. Thus, they can serve as diagnostic/prognostic biomarkers. The knowledge on circulating miRNAs for clear cell renal cell carcin
Externí odkaz:
https://doaj.org/article/0e718b40ced4429c8761d3b7077c89eb