Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Yup Kang"'
Protective effect of empagliflozin against palmitate-induced lipotoxicity through AMPK in H9c2 cells
Autor:
Min-Woo Song, Wenhao Cui, Chang-Gun Lee, Rihua Cui, Young Ho Son, Young Ha Kim, Yujin Kim, Hae Jin Kim, Sung-E. Choi, Yup Kang, Tae Ho Kim, Ja Young Jeon, Kwan-Woo Lee
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have recently emerged as novel cardioprotective agents. However, their direct impact on cardiomyocyte injury is yet to be studied. In this work, we investigate the underlying molecular mechanisms of e
Externí odkaz:
https://doaj.org/article/fd3b7cc0b20041aeb1137ab7ac8e9da9
Autor:
Yu Jung Heo, Nami Lee, Sung-E. Choi, Ja Young Jeon, Seung Jin Han, Dae Jung Kim, Yup Kang, Kwan Woo Lee, Hae Jin Kim
Publikováno v:
Mediators of Inflammation, Vol 2023 (2023)
Background. Inflammation is a major cause of hepatic tissue damage and accelerates the progression of nonalcoholic fatty liver disease (NAFLD). Amphiregulin (AREG), an epidermal growth factor receptor ligand, is associated with human liver cirrhosis
Externí odkaz:
https://doaj.org/article/5c62e645db0548c08bfcd88bc63cdeae
Autor:
Tae Hwan Shin, Balachandran Manavalan, Da Yeon Lee, Shaherin Basith, Chan Seo, Man Jeong Paik, Sang-Wook Kim, Haewoon Seo, Ju Yeon Lee, Jin Young Kim, A Young Kim, Jee Min Chung, Eun Joo Baik, Seong Ho Kang, Dong-Kug Choi, Yup Kang, M. Maral Mouradian, Gwang Lee
Publikováno v:
Particle and Fibre Toxicology, Vol 18, Iss 1, Pp 1-24 (2021)
Abstract Background Nanoparticles have been utilized in brain research and therapeutics, including imaging, diagnosis, and drug delivery, owing to their versatile properties compared to bulk materials. However, exposure to nanoparticles leads to thei
Externí odkaz:
https://doaj.org/article/5a3f65fab7ff4f3ea7bfc98a0d28a485
Autor:
Chang-Gun Lee, Soo-Jin Lee, Seokho Park, Sung-E Choi, Min-Woo Song, Hyo Won Lee, Hae Jin Kim, Yup Kang, Kwan Woo Lee, Hwan Myung Kim, Jong-Young Kwak, In-Jeong Lee, Ja Young Jeon
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9978 (2022)
The accumulation of hepatic lipid droplets (LDs) is a hallmark of non-alcoholic fatty liver disease (NAFLD). Appropriate degradation of hepatic LDs and oxidation of complete free fatty acids (FFAs) are important for preventing the development of NAFL
Externí odkaz:
https://doaj.org/article/b34e3d41f59a4508be2c3fbe89e5400d
Autor:
Nami Lee, Yu Jung Heo, Sung-E Choi, Ja Young Jeon, Seung Jin Han, Dae Jung Kim, Yup Kang, Kwan Woo Lee, Hae Jin Kim
Publikováno v:
Journal of Immunology Research, Vol 2021 (2021)
Background. Sodium-glucose cotransporter 2 (SGLT2) and dipeptidyl peptidase-4 (DPP-4) inhibitors are glucose-lowering drugs whose anti-inflammatory properties have recently become useful in tackling metabolic syndromes in chronic inflammatory disease
Externí odkaz:
https://doaj.org/article/f80b1e9f48bd4005bb8827e38d0b6477
Autor:
Soo Jin Lee, Sung-E Choi, Han Byeol Lee, Min-Woo Song, Young Ha Kim, Jae Yeop Jeong, Yup Kang, Hae Jin Kim, Tae Ho Kim, Ja Young Jeon, Kwan Woo Lee
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Histone deacetylase (HDAC) inhibitors, which regulate gene expression by inhibiting the deacetylation of histones and nonhistone proteins, have been shown to exert a wide array of biological effects; these include anti-cancer, anti-obesity, and anti-
Externí odkaz:
https://doaj.org/article/8b5e571ff421483ebf7529b397729770
Autor:
Yu-Jung Heo, Nami Lee, Sung-E Choi, Ja-Young Jeon, Seung-Jin Han, Dae-Jung Kim, Yup Kang, Kwan-Woo Lee, Hae-Jin Kim
Publikováno v:
Biomedicines, Vol 10, Iss 5, p 1032 (2022)
Hepatic fibrosis is the excessive production and deposition of the extracellular matrix, resulting in the activation of the fibrogenic phenotype of hepatic stellate cells (HSCs). The Hippo/Yes-associated protein (YAP) signalling pathway is a highly c
Externí odkaz:
https://doaj.org/article/b5095a908e824f5593c5d0cfaa9ae7a5
Autor:
Hwa Joung Lee, Rihua Cui, Sung-E Choi, Ja Young Jeon, Hae Jin Kim, Tae Ho Kim, Yup Kang, Kwan-Woo Lee
Publikováno v:
Food & Nutrition Research, Vol 62, Iss 0, Pp 1-10 (2018)
Background: Bitter melon (BM) improves glucose level, lipid homeostasis, and insulin resistance in vivo. However, the preventive mechanism of BM in nonalcoholic fatty liver disease (NAFLD) has not been elucidated yet. Aim & Design: To determine the p
Externí odkaz:
https://doaj.org/article/09427701510547708005cf27dbbb3762
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 9952 (2021)
We aimed to investigate the effect of acute glucose shift on the activation of the NLRP3 inflammasome, IL-1β secretion, and underlying signaling pathways in THP-1 cells. THP-1 cells were divided into four groups and exposed to the following glucose
Externí odkaz:
https://doaj.org/article/832409db1a654d45930d03b1155a3166
Autor:
Yu Jung Heo, Sung-E Choi, Ja Young Jeon, Seung Jin Han, Dae Jung Kim, Yup Kang, Kwan Woo Lee, Hae Jin Kim
Publikováno v:
Journal of Diabetes Research, Vol 2019 (2019)
Background. It has been suggested that visfatin, which is an adipocytokine, exhibits proinflammatory properties and is associated with insulin resistance. Insulin resistance and inflammation are the principal pathogeneses of nonalcoholic fatty liver
Externí odkaz:
https://doaj.org/article/adf41ab9eca24ca99378aa47a859ceb6