Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Yunzi Luo"'
Autor:
Qun Zhou, Yatong Zhao, Changqiang Ke, Haojun Wang, Sheng Gao, Hui Li, Yan Zhang, Yang Ye, Yunzi Luo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The multifunctional proteins of class 2 CRISPR systems such as Cas9, have been employed to activate cryptic biosynthetic gene clusters (BGCs) in Streptomyces, which represent a large and hidden reservoir of natural products. However, such ap
Externí odkaz:
https://doaj.org/article/9cb30889cebe4250b09911efaeda39ed
Publikováno v:
Synthetic and Systems Biotechnology, Vol 9, Iss 3, Pp 600-608 (2024)
Streptomyces offer a wealth of naturally occurring compounds with diverse structures, many of which possess significant pharmaceutical values. However, new product exploration and increased yield of specific compounds in Streptomyces have been techni
Externí odkaz:
https://doaj.org/article/1e8879fdca3c49e79c39b2dfb2917aa2
Autor:
Huayi Liu, Qingjie Xiao, Xinxin Wu, He Ma, Jian Li, Xufan Guo, Zhenyu Liu, Yan Zhang, Yunzi Luo
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHPS) is a key enzyme in the shikimate pathway for the biosynthesis of aromatic compounds. L-Phe and L-Tyr bind to the two main DAHPS isoforms and inhibit their enzyme activities, respec
Externí odkaz:
https://doaj.org/article/2a657f1d8103435790d2c64d30c7a2fe
Autor:
Chen Wang, Leiye Yu, Jiying Zhang, Yanxia Zhou, Bo Sun, Qingjie Xiao, Minhua Zhang, Huayi Liu, Jinhong Li, Jialu Li, Yunzi Luo, Jie Xu, Zhong Lian, Jingwen Lin, Xiang Wang, Peng Zhang, Li Guo, Ruobing Ren, Dong Deng
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
PfENT1 is a promising antimalarial drug target. Here, authors report cryo-EM structures of PfENT1 that, together with biochemical work, suggests PfENT1 is an inosine transporter and describe the inhibitory mechanism of the endofacial inhibitor, GSK4.
Externí odkaz:
https://doaj.org/article/09dc3993856a4849af7df41b65a76f74
Publikováno v:
Synthetic and Systems Biotechnology, Vol 7, Iss 1, Pp 648-656 (2022)
Microbes can produce valuable natural products widely applied in medicine, food and other important fields. Nevertheless, it is usually challenging to achieve ideal industrial yields due to low production rate and poor toxicity tolerance. Evolution i
Externí odkaz:
https://doaj.org/article/fbc2abfab4e84d44a38a185a11287b8d
Publikováno v:
Journal of Fungi, Vol 9, Iss 9, p 907 (2023)
Natural sugar substitutes are safe, stable, and nearly calorie-free. Thus, they are gradually replacing the traditional high-calorie and artificial sweeteners in the food industry. Currently, the majority of natural sugar substitutes are extracted fr
Externí odkaz:
https://doaj.org/article/4a718aa37006404b814bd7331c03ffe9
Publikováno v:
Microbial Biotechnology, Vol 14, Iss 6, Pp 2605-2616 (2021)
Summary Tyrosol and its glycosylated product salidroside are important ingredients in pharmaceuticals, nutraceuticals and cosmetics. Despite the ability of Saccharomyces cerevisiae to naturally synthesize tyrosol, high yield from de novo synthesis re
Externí odkaz:
https://doaj.org/article/4b6baa0feea3463a9e09073bb09a7277
Publikováno v:
Microbial Biotechnology, Vol 14, Iss 2, Pp 708-725 (2021)
Summary Daptomycin (DAP) is a novel microbial lipopeptide antibiotic synthesized by the DAP biosynthetic gene cluster dpt of Streptomyces roseosporus (S. roseosporus). DptP gene locates upstream of dpt and confers DAP resistance to Streptomyces ambof
Externí odkaz:
https://doaj.org/article/9cf5193803d04297b129fce94eb6f926
Publikováno v:
Synthetic and Systems Biotechnology, Vol 5, Iss 2, Pp 49-58 (2020)
Streptomyces is an important treasure trove for natural products discovery. In recent years, many scientists focused on the genetic modification and metabolic regulation of Streptomyces to obtain diverse bioactive compounds with high yields. This rev
Externí odkaz:
https://doaj.org/article/d74bd13f949d46e6be732709eb9db5b8
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
pRS episomal plasmids are widely used in Saccharomyces cerevisiae, owing to their easy genetic manipulations and high plasmid copy numbers (PCNs). Nevertheless, their broader application is hampered by the instability of the pRS plasmids. In this stu
Externí odkaz:
https://doaj.org/article/29eb2d691b574494b8ad8b594d0e1d19