Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Yunzhang Wang"'
Autor:
Yelin Zhao, Xinxiu Li, Joseph Loscalzo, Martin Smelik, Oleg Sysoev, Yunzhang Wang, A. K. M. Firoj Mahmud, Dina Mansour Aly, Mikael Benson
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background Characterization of shared cancer mechanisms have been proposed to improve therapy strategies and prognosis. Here, we aimed to identify shared cell–cell interactions (CCIs) within the tumor microenvironment across multiple solid
Externí odkaz:
https://doaj.org/article/767e39a8ea4f431d828c3117e29984c6
Autor:
Xia Li, Alexander Ploner, Yunzhang Wang, Jonathan K. L. Mak, Yi Lu, Patrik K. E. Magnusson, Juulia Jylhävä, Sara Hägg
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 11, Iss 12, Pp n/a-n/a (2023)
Abstract Background C‐reactive protein (CRP) is a sensitive biomarker of inflammation with moderate heritability. The role of rare functional genetic variants in relation to serum CRP is understudied. We aimed to examine gene mutation burden of pro
Externí odkaz:
https://doaj.org/article/b783b457074d4aa093cac96a0c0f3c33
Publikováno v:
Epigenetics, Vol 18, Iss 1 (2023)
Differences in gene-wide DNA methylation of the Alzheimer’s disease (AD)-associated genes BIN1, HLA-DRB5, SORL1, SLC24A4, and ABCA7 are reported to be associated with AD in post-mortem brain samples. We investigated whether the same associations co
Externí odkaz:
https://doaj.org/article/4315579fa2a54c28bb421ac5755d831c
Autor:
Ge Bai, Yunzhang Wang, Ralf Kuja-Halkola, Xia Li, Yasutake Tomata, Ida K. Karlsson, Nancy L. Pedersen, Sara Hägg, Juulia Jylhävä
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-12 (2021)
Abstract Background Frailty has been identified as a risk factor for cognitive impairment and dementia. However, it is not known whether familial factors, such as genetics and shared environmental factors, underlie this association. We analyzed the a
Externí odkaz:
https://doaj.org/article/cea50f08ec944c578a6b113da1ad06dc
Autor:
Daniel L. McCartney, Josine L. Min, Rebecca C. Richmond, Ake T. Lu, Maria K. Sobczyk, Gail Davies, Linda Broer, Xiuqing Guo, Ayoung Jeong, Jeesun Jung, Silva Kasela, Seyma Katrinli, Pei-Lun Kuo, Pamela R. Matias-Garcia, Pashupati P. Mishra, Marianne Nygaard, Teemu Palviainen, Amit Patki, Laura M. Raffield, Scott M. Ratliff, Tom G. Richardson, Oliver Robinson, Mette Soerensen, Dianjianyi Sun, Pei-Chien Tsai, Matthijs D. van der Zee, Rosie M. Walker, Xiaochuan Wang, Yunzhang Wang, Rui Xia, Zongli Xu, Jie Yao, Wei Zhao, Adolfo Correa, Eric Boerwinkle, Pierre-Antoine Dugué, Peter Durda, Hannah R. Elliott, Christian Gieger, The Genetics of DNA Methylation Consortium, Eco J. C. de Geus, Sarah E. Harris, Gibran Hemani, Medea Imboden, Mika Kähönen, Sharon L. R. Kardia, Jacob K. Kresovich, Shengxu Li, Kathryn L. Lunetta, Massimo Mangino, Dan Mason, Andrew M. McIntosh, Jonas Mengel-From, Ann Zenobia Moore, Joanne M. Murabito, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Miina Ollikainen, James S. Pankow, Nancy L. Pedersen, Annette Peters, Silvia Polidoro, David J. Porteous, Olli Raitakari, Stephen S. Rich, Dale P. Sandler, Elina Sillanpää, Alicia K. Smith, Melissa C. Southey, Konstantin Strauch, Hemant Tiwari, Toshiko Tanaka, Therese Tillin, Andre G. Uitterlinden, David J. Van Den Berg, Jenny van Dongen, James G. Wilson, John Wright, Idil Yet, Donna Arnett, Stefania Bandinelli, Jordana T. Bell, Alexandra M. Binder, Dorret I. Boomsma, Wei Chen, Kaare Christensen, Karen N. Conneely, Paul Elliott, Luigi Ferrucci, Myriam Fornage, Sara Hägg, Caroline Hayward, Marguerite Irvin, Jaakko Kaprio, Deborah A. Lawlor, Terho Lehtimäki, Falk W. Lohoff, Lili Milani, Roger L. Milne, Nicole Probst-Hensch, Alex P. Reiner, Beate Ritz, Jerome I. Rotter, Jennifer A. Smith, Jack A. Taylor, Joyce B. J. van Meurs, Paolo Vineis, Melanie Waldenberger, Ian J. Deary, Caroline L. Relton, Steve Horvath, Riccardo E. Marioni
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-25 (2021)
Abstract Background Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation in these measures in p
Externí odkaz:
https://doaj.org/article/d9c2f9d64559417981cafac594b7aed0
Autor:
Gabriel Sturm, Andres Cardenas, Marie-Abèle Bind, Steve Horvath, Shuang Wang, Yunzhang Wang, Sara Hägg, Michio Hirano, Martin Picard
Publikováno v:
Epigenetics, Vol 14, Iss 10, Pp 961-976 (2019)
Aging is associated with progressive and site-specific changes in DNA methylation (DNAm). These global changes are captured by DNAm clocks that accurately predict chronological age in humans but relatively little is known about how clocks perform in
Externí odkaz:
https://doaj.org/article/42ef42540e03474eae2c15fa04ffc5ce
Publikováno v:
EBioMedicine, Vol 45, Iss , Pp 487-494 (2019)
Background: High circulating low-density lipoprotein cholesterol (LDL-C) is a major risk factor for atherosclerosis and age-associated cardiovascular events. Long-term dyslipidaemia could contribute to the development of frailty in older individuals
Externí odkaz:
https://doaj.org/article/18ca1beef93048e7af86a6675000a17c
Autor:
Xia Li, Alexander Ploner, Yunzhang Wang, Yiqiang Zhan, Nancy L Pedersen, Patrik KE Magnusson, Juulia Jylhävä, Sara Hägg
Publikováno v:
EBioMedicine, Vol 66, Iss , Pp 103318- (2021)
Background: Biomarker-disease relationships are extensively investigated. However, associations between common clinical biomarkers and healthspan, the disease-free lifespan, are largely unknown. We aimed to explore the predictive values of ten biomar
Externí odkaz:
https://doaj.org/article/96f328953545444da3bd2570b63ff25a
Autor:
Xia Li, Alexander Ploner, Yunzhang Wang, Patrik KE Magnusson, Chandra Reynolds, Deborah Finkel, Nancy L Pedersen, Juulia Jylhävä, Sara Hägg
Publikováno v:
eLife, Vol 9 (2020)
Biological age measurements (BAs) assess aging-related physiological change and predict health risks among individuals of the same chronological age (CA). Multiple BAs have been proposed and are well studied individually but not jointly. We included
Externí odkaz:
https://doaj.org/article/2bdb413e102a476696b6dcfcca8d4638
Autor:
Yunzhang Wang, Robert Karlsson, Erik Lampa, Qian Zhang, Åsa K. Hedman, Malin Almgren, Catarina Almqvist, Allan F. McRae, Riccardo E. Marioni, Erik Ingelsson, Peter M. Visscher, Ian J. Deary, Lars Lind, Tiffany Morris, Stephan Beck, Nancy L. Pedersen, Sara Hägg
Publikováno v:
Epigenetics, Vol 13, Iss 9, Pp 975-987 (2018)
Age-related changes in DNA methylation were observed in cross-sectional studies, but longitudinal evidence is still limited. Here, we aimed to characterize longitudinal age-related methylation patterns using 1011 blood samples collected from 385 Swed
Externí odkaz:
https://doaj.org/article/8cb86eb30c004e5a881bc20d1f89c60a