Výsledky vyhledávání - "Yunyu Spence"

Akademický článek

Preventing packaging of translatable P5-associated DNA contaminants in recombinant AAV vector preps

Autor: Mark A. Brimble, Pei-Hsin Cheng, Stephen M. Winston, Isaiah L. Reeves, Aisha Souquette, Yunyu Spence, Junfang Zhou, Yong-Dong Wang, Christopher L. Morton, Marcus Valentine, Paul G. Thomas, Amit C. Nathwani, John T. Gray, Andrew M. Davidoff

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 24, Iss , Pp 280-291 (2022)

Recombinant adeno-associated virus (rAAV) vectors are increasingly being used for clinical gene transfer and have shown great potential for the treatment of several monogenic disorders. However, contaminant DNA from producer plasmids can be packaged

Externí odkaz: https://doaj.org/article/9ce90bd19a374a6086d2a19259d8a399

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Akademický článek

Distribution of AAV8 particles in cell lysates and culture media changes with time and is dependent on the recombinant vector

Autor: Bryan A Piras, Jason E Drury, Christopher L Morton, Yunyu Spence, Timothy D Lockey, Amit C Nathwani, Andrew M Davidoff, Michael M Meagher

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)

With clinical trials ongoing, efficient clinical production of adeno-associated virus (AAV) to treat large numbers of patients remains a challenge. We compared distribution of AAV8 packaged with Factor VIII (FVIII) in cell culture media and lysates o

Externí odkaz: https://doaj.org/article/ca5c69d1e9e44dc2a9d43c8a059560b4

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AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage

Autor: Christopher Binny, Christopher L. Morton, Adrian J. Thrasher, John T. Gray, John H. McVey, Alice F. Tarantal, Amit C. Nathwani, Andrew M. Davidoff, Hanna Kymalainen, Francis J. Castellino, Edward G. D. Tuddenham, Suzanne M. K. Buckley, Yunyu Spence, Simon N. Waddington, Jenny McIntosh, Marco Della Peruta

Publikováno v: Blood

We explored adeno-associated viral vector (AAV)–mediated gene transfer in the perinatal period in animal models of severe congenital factor VII (FVII) deficiency, a disease associated with early postnatal life-threatening hemorrhage. In young adult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96e8d6fc5f2885f3e00d7cdbef47755
https://doi.org/10.1182/blood-2011-09-377630

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Continuous local delivery of interferon-β stabilizes tumor vasculature in an orthotopic glioblastoma xenograft resection model

Autor: Amit C. Nathwani, W. Shannon Orr, Lawrence M. Pfeffer, Andrew M. Davidoff, Catherine Y.C. Ng, Thomas L. Sims, Regan F. Williams, Christopher Duntsch, Jason W. Denbo, Christopher L. Morton, Junfang Zhou, Yunyu Spence

Publikováno v: Surgery. 150:497-504

Background High-grade glioblastomas have immature, leaky tumor blood vessels that impede the efficacy of adjuvant therapy. We assessed the ability of human interferon (hIFN)-β delivered locally via gene transfer to effect vascular stabilization in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a64242fc0f3e3120b246ddbd89a844
https://doi.org/10.1016/j.surg.2011.07.044

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Long-term Safety and Efficacy Following Systemic Administration of a Self-complementary AAV Vector Encoding Human FIX Pseudotyped With Serotype 5 and 8 Capsid Proteins

Publikováno v: Molecular Therapy. 19:876-885

Adeno-associated virus vectors (AAV) show promise for liver-targeted gene therapy. In this study, we examined the long-term consequences of a single intravenous administration of a self-complementary AAV vector (scAAV2/ 8-LP1-hFIXco) encoding a codon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ea15ded979f152e6488cff898a663b
https://doi.org/10.1038/mt.2010.274

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Safe and efficient transduction of the liver after peripheral vein infusion of self-complementary AAV vector results in stable therapeutic expression of human FIX in nonhuman primates

Autor: Elaine Gray, Jenny McIntosh, Amit C. Nathwani, Yunyu Spence, John T. Gray, Melanie Cochrane, Junfang Zhou, Catherine Y.C. Ng, Edward G. D. Tuddenham, Andrew M. Davidoff

Publikováno v: Blood. 109:1414-1421

The safety and efficacy of peripheral venous administration of a self-complementary adeno-associated viral vector encoding the human FIX gene (scAAV-LP1-hFIXco) was evaluated in nonhuman primates for gene therapy of hemophilia B. Peripheral vein infu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b33818eeaa3381996e6b9e47ecd21a
https://doi.org/10.1182/blood-2006-03-010181

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Sex significantly influences transduction of murine liver by recombinant adeno-associated viral vectors through an androgen-dependent pathway

Autor: Amit C. Nathwani, Yunyu Spence, Catherine Y.C. Ng, Andrew M. Davidoff, Junfang Zhou

Publikováno v: Blood. 102:480-488

A systematic evaluation of the influence of sex on transduction by recombinant adeno-associated viral vector (rAAV) indicated that transgene expression after liver-targeted delivery of vector particles was between 5- to 13-fold higher in male mice co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdb99623e7b13bea655ce2086286a047
https://doi.org/10.1182/blood-2002-09-2889

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Rapamycin increases neuroblastoma xenograft and host stromal derived osteoprotegerin inhibiting osteolytic bone disease in a bone metastasis model

Autor: Lisa M. McGregor, Joseph E. Hartwich, Catherine Y.C. Ng, Wayne L. Furman, Jillian M. McLaughlin, Andrew M. Davidoff, W. Shannon Orr, Yunyu Spence

Osteoprotegerin (OPG) is a decoy receptor for the Receptor of NF-κB (RANK) ligand that can inhibit osteoclastogenesis. Previous studies have suggested that Mammalian Target of Rapamycin (mTOR) inhibition upregulates OPG production. We tested the hyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c3cf18ba7b9aab743b8346cc2b0f50d
https://europepmc.org/articles/PMC3584337/

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Distribution of AAV8 particles in cell lysates and culture media changes with time and is dependent on the recombinant vector

Autor: Amit C. Nathwani, Andrew M. Davidoff, Jason E. Drury, Yunyu Spence, Bryan A. Piras, Timothy D. Lockey, Christopher L. Morton, Michael M Meagher

Publikováno v: Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c935175599dfa2d5ef56b52eaf695468
https://doi.org/10.1038/mtm.2016.15

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