Characterization and Differential Cytotoxicity of Gramicidin Nanoparticles Combined with Cationic Polymer or Lipid Bilayer

Autor: Yunys Pérez-Betancourt, Rachel Zaia, Marina Franchi Evangelista, Rodrigo Tadeu Ribeiro, Bruno Murillo Roncoleta, Beatriz Ideriha Mathiazzi, Ana Maria Carmona-Ribeiro

Publikováno v: Pharmaceutics, Vol 14, Iss 10, p 2053 (2022)

Gramicidin (Gr) nanoparticles (NPs) and poly (diallyl dimethyl ammonium) chloride (PDDA) water dispersions were characterized and evaluated against Gram-positive and Gram-negative bacteria and fungus. Dynamic light scattering for sizing, zeta potenti

Externí odkaz: https://doaj.org/article/2e8d4231205f41d9a7ffdf56980995ab

Cationic Nanostructures for Vaccines Design

Autor: Ana Maria Carmona-Ribeiro, Yunys Pérez-Betancourt

Publikováno v: Biomimetics, Vol 5, Iss 3, p 32 (2020)

Subunit vaccines rely on adjuvants carrying one or a few molecular antigens from the pathogen in order to guarantee an improved immune response. However, to be effective, the vaccine formulation usually consists of several components: an antigen carr

Externí odkaz: https://doaj.org/article/27ce500ef30e4888b9c029ba93aff068

Cationic Nanostructures as Adjuvants for Vaccines

Autor: Ana Maria, Carmona-Ribeiro, Beatriz Ideriha, Mathiazzi, Yunys, Pérez-Betancourt

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2412

Spherical or discoidal lipid polymer nanostructures bearing cationic charges successfully adsorb a variety of oppositely charged antigens (Ag) such as proteins, peptides, nucleic acids, or oligonucleotides. This report provides instructions for the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::39f21cf25807a42062f40267e7f71b95
https://pubmed.ncbi.nlm.nih.gov/34918247

Cationic and Biocompatible Polymer/Lipid Nanoparticles as Immunoadjuvants

Autor: Ana Maria Carmona-Ribeiro, Bianca de Carvalho Lins Fernandes Távora, Yunys Pérez-Betancourt, Péricles Marques Araujo, Daniele Rodrigues Pereira, Eliana L. Faquim-Mauro

Publikováno v: Pharmaceutics
Volume 13
Issue 11
Pharmaceutics, Vol 13, Iss 1859, p 1859 (2021)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Nanostructures have been of paramount importance for developing immunoadjuvants. They must be cationic and non-cytotoxic, easily assembling with usually oppositely charged antigens such as proteins, haptens or nucleic acids for use in vaccines. We ob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e76d8973f22b53222bc8bff3d3b2c0d
http://europepmc.org/articles/PMC8621050

Simple Nanoparticles from the Assembly of Cationic Polymer and Antigen as Immunoadjuvants

Autor: Ana Maria Carmona-Ribeiro, Eliana L. Faquim-Mauro, Colombini M, Távora Bclf, Yunys Pérez-Betancourt

Publikováno v: Vaccines
Volume 8
Issue 1
Vaccines, Vol 8, Iss 1, p 105 (2020)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Since antigens are negatively charged, they combine well with positively charged adjuvants. Here, ovalbumin (OVA) (0.1 mg·
mL-1) and poly (diallyldimethylammonium chloride) (PDDA) (0.01 mg·
mL-1) yielded PDDA/OVA assemblies char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a402f1c98d9db5314fde279c2c6d7dcd
http://europepmc.org/articles/PMC7157673