Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Yunxin Bo"'
Autor:
Kevin Yang, Rod Cupples, Gwyneth Van, Nobuko Nishimura, Longbin Liu, David J. St. Jean, Clarence Hale, Glenn Sivits, Jie Chen, Nuria A. Tamayo, Steven R. Jordan, Fang-Tsao Hong, Mark H. Norman, Michael D. Bartberger, Yunxin Bo, Christopher H. Fotsch, Samer Chmait, Seifu Tadesse, David Lloyd
Publikováno v:
Journal of Medicinal Chemistry. 58:4462-4482
The glucokinase-glucokinase regulatory protein (GK-GKRP) complex plays an important role in controlling glucose homeostasis in the liver. We have recently disclosed a series of arylpiperazines as in vitro and in vivo disruptors of the GK-GKRP complex
Autor:
Yunxin Bo, Tisha San Miguel, Nobuko Nishimura, Jian Jiang, Douglas A. Whittington, Paul E. Hughes, Sean Caenepeel, Mark H. Norman, John D. McCarter, Erin L. Mullady, Daniel J. Freeman, Kevin Yang, Ryan Wurz, Longbin Liu, Raju Subramanian, Kristin L. Andrews, Ling Wang, Liping H. Pettus, Nancy Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:5714-5720
Phosphoinositide 3-kinase (PI3K) is an important target in oncology due to the deregulation of the PI3K/Akt signaling pathway in a wide variety of tumors. A series of 4-amino-6-methyl-1,3,5-triazine sulfonamides were synthesized and evaluated as inhi
Autor:
Sonya G. Lehto, Weiya Wang, Narender R. Gavva, Hong Deng, Mark H. Norman, Lana Klionsky, Nobuko Nishimura, Brad Youngblood, Phi Tang, Vu Van Ma, Jiyun Chen, Vijay Keshav Gore, Michael D. Bartberger, Nuria A. Tamayo, Tiffany L. Correll, Yunxin Bo
Publikováno v:
Journal of Medicinal Chemistry. 55:1593-1611
The transient receptor potential melastatin type 8 (TRPM8) is a nonselective cation channel primarily expressed in a subpopulation of sensory neurons that can be activated by a wide range of stimuli, including menthol, icilin, and cold temperatures (
Autor:
Ling Wang, Leeanne Zalameda, Hongyu Liao, Kristin L. Andrews, Yunxin Bo, Nobuko Nishimura, Paul E. Hughes, John D. McCarter, Erin L. Mullady, Tisha San Miguel, Douglas A. Whittington, Sean Caenepeel, Nancy Zhang, Daniel J. Freeman, Mark H. Norman, Shon Booker, Aaron C. Siegmund, Nuria A. Tamayo, Marian C. Bryan, Raju Subramanian, Kevin Yang, Longbin Liu
Publikováno v:
Journal of Medicinal Chemistry. 54:4735-4751
The phosphoinositide 3-kinase (PI3K) family catalyzes the ATP-dependent phosphorylation of the 3'-hydroxyl group of phosphatidylinositols and plays an important role in cell growth and survival. There is abundant evidence demonstrating that PI3K sign
Autor:
Mqhele Ncube, Lillian Liao, Rami Tamir, Yunxin Bo, Narender R. Gavva, James J. S. Treanor, Partha P. Chakrabarti, Markian Stec, Nuria A. Tamayo, Mark H. Norman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5118-5122
Clinical candidate AMG 517 (1) is a potent antagonist toward multiple modes of activation of TRPV1; however, it suffers from poor solubility. Analogs with various substituents at the R region of 3 were prepared to improve the solubility while maintai
Autor:
Qingyian Liu, Randall W. Hungate, Rami Tamir, Shimin Xu, Elizabeth M. Doherty, James J. S. Treanor, Christopher H. Fotsch, Mark H. Norman, Lana Klionsky, Yunxin Bo, Nianhe Han, Ning Xi, Narender R. Gavva
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:5211-5217
A thiazole derivative, 2-(2,6-dichlorobenzyl)-N-(4-isopropylphenyl) thiazole-4-carboxamide (1), was identified as a TRPV1 antagonist. We synthesized various thiazole analogs and evaluated them for their ability to block capsaicin- or acid-induced cal
Autor:
Nuria A. Tamayo, Shimin Xu, Michael G. Kelly, Duncan M. Smith, Ning Chen, Michelle Carmouche, Mark H. Norman, Martin H. Goldberg, James Davis, Christopher H. Fotsch, Clarence Hale, Ning Xi, Markian Stec, James W. Baumgartner, Premilla Arasasingham, Nianhe Han, Feng-Yin Hsieh, Qingyian Liu, Yunxin Bo, Anthony W. Bannon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:1623-1627
The biological activity for a set of melanocortin-4 receptor (MC4R) agonists containing a piperazine core with an ortho-substituted aryl sulfonamide is described. Compounds from this set had binding and functional activities at MC4R less than 30 nM.
Autor:
Vu Van Ma, Maosheng Zhang, Nuria A. Tamayo, Vijay Keshav Gore, Weiya Wang, Phi Tang, Holger Monenschein, Daniel B. Horne, Mark H. Norman, Michael D. Bartberger, Yunxin Bo, Jeffrey Clarine, Thomas T. Nguyen, Carl Davis, Beth D. Youngblood, Matthew R. Kaller, Sonya G. Lehto, Narender R. Gavva, Nobuko Nishimura
Publikováno v:
Journal of medicinal chemistry. 57(7)
Transient receptor potential melastatin 8 (TRPM8) is a nonselective cation channel expressed in a subpopulation of sensory neurons in the peripheral nervous system. TRPM8 is the predominant mammalian cold temperature thermosensor and is activated by
Autor:
Yunxin Bo, Yong Tao, Sylvain Daigneault, Natesan Selvakumar, Yong-Zhou Hu, Derrick L. J. Clive, Shaoyi Sun, Yong-Jin Wu
Publikováno v:
Chemical Communications. :1341-1350
The synthesis of (−)-calicheamicinone (2), the carbohydrates 88, 101, 111, 119 and 120, and the hexasubstituted benzene 139, is described; these compounds formally represent the subunits of the antitumor antibiotic calicheamicin γ1I (1).
Publikováno v:
Tetrahedron. 55:3277-3290
Diels-Alder reaction between ketene acetal 3 and the β-nitroacrylate ester 12 of (−)-8-phenylmenthol gave optically pure ketone 17. This substance was modified in such a way as to remove the chiral auxiliary and afford the epimeric silyl ethers 20