Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Yunxiang, Mu"'
Autor:
Kevin M. McBride, Hyunsuk Kil, Yunxiang Mu, Joshua B. Plummer, Jaeho Lee, Maciej J. Zelazowski, Manu Sebastian, Martin C. Abba, C. Marcelo Aldaz
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
WWOX (WW domain containing oxidoreductase) expression loss is common in various cancers and characteristic of poor prognosis. Deletions, translocations, and loss of expression affecting the WWOX gene are a common feature of various B cell neoplasms s
Externí odkaz:
https://doaj.org/article/e5fe1f8308c34c35a6c5898c7b8a631f
Autor:
Yunxiang Mu, Joshua B. Plummer, Monika A. Zelazowska, Somnath Paul, Qiwen Dong, Zaowen Chen, Laurie T. Krug, Kevin M. McBride
Publikováno v:
bioRxiv
Antibodies are powerful tools to detect expressed proteins. However off-target recognition can confound their use. Therefore, careful characterization is needed to validate specificity in distinct applications. Here we report the sequence and charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc4ef59784fd0448ed7e8f40c054e792
https://europepmc.org/articles/PMC10245680/
https://europepmc.org/articles/PMC10245680/
Autor:
Zhengzhou Ying, Swanand Hardikar, Joshua B. Plummer, Tewfik Hamidi, Bin Liu, Yueping Chen, Jianjun Shen, Yunxiang Mu, Kevin M. McBride, Taiping Chen
Publikováno v:
bioRxiv
Immunodeficiency, centromeric instability and facial anomalies (ICF) syndrome is a rare autosomal recessive disorder characterized by DNA hypomethylation and antibody deficiency. It is caused by mutations inDNMT3B, ZBTB24, CDCA7orHELLS. While progres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0919b7e1269f323706365ef6d597380c
https://doi.org/10.1101/2023.03.09.531982
https://doi.org/10.1101/2023.03.09.531982
Autor:
Qiwen Dong, Kyle R. Smith, Darby G. Oldenburg, Maxwell Shapiro, William R. Schutt, Laraib Malik, Joshua B. Plummer, Yunxiang Mu, Thomas MacCarthy, Douglas W. White, Kevin M. McBride, Laurie T. Krug
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT Misincorporation of uracil or spontaneous cytidine deamination is a common mutagenic insult to DNA. Herpesviruses encode a viral uracil-DNA glycosylase (vUNG) and a viral dUTPase (vDUT), each with enzymatic and nonenzymatic functions. Howeve
Externí odkaz:
https://doaj.org/article/e0bb07380d1b4f38bdcc807e729ffc60
Autor:
Yunxiang Mu, Kevin M. McBride
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 5 (2018)
The mutations induced by activation-induced cytidine deaminase (AID) trigger antibody diversification but can cause genome instability. We find that AID phosphorylation is an important determinant of “off-target” mutagenesis and identify a drug t
Externí odkaz:
https://doaj.org/article/9a66c05828d644f79f5074a1b51753a2
Autor:
Matthew J Yousefzadeh, David W Wyatt, Kei-Ichi Takata, Yunxiang Mu, Sean C Hensley, Junya Tomida, Göran O Bylund, Sylvie Doublié, Erik Johansson, Dale A Ramsden, Kevin M McBride, Richard D Wood
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004654 (2014)
Although a defect in the DNA polymerase POLQ leads to ionizing radiation sensitivity in mammalian cells, the relevant enzymatic pathway has not been identified. Here we define the specific mechanism by which POLQ restricts harmful DNA instability. Ou
Externí odkaz:
https://doaj.org/article/4231e2dcb1ae482db01a1c9297868d19
Autor:
Joshua B. Plummer, Martín Carlos Abba, Claudio M Aldaz, Manu M. Sebastian, Jaeho Lee, Kevin M. McBride, Maciej Jakub Zelazowski, Yunxiang Mu, Hyunsuk Kil
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Frontiers in Oncology
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Frontiers in Oncology
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
WWOX (WW domain containing oxidoreductase) expression loss is common in various cancers and characteristic of poor prognosis. Deletions, translocations, and loss of expression affecting the WWOX gene are a common feature of various B cell neoplasms s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dce6b37de6c0f1f262d03e75da3550c7
http://sedici.unlp.edu.ar/handle/10915/128773
http://sedici.unlp.edu.ar/handle/10915/128773
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::226362064fa0dcaae4e527573d7b9695
https://doi.org/10.1096/fasebj.2019.33.1_supplement.635.23
https://doi.org/10.1096/fasebj.2019.33.1_supplement.635.23
Autor:
Kevin M. McBride, Yunxiang Mu
Publikováno v:
Molecular & Cellular Oncology
The mutations induced by activation-induced cytidine deaminase (AID) trigger antibody diversification but can cause genome instability. We find that AID phosphorylation is an important determinant of “off-target” mutagenesis and identify a drug t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e359d9bd5921044ea4fcb17846758bf6
https://pubmed.ncbi.nlm.nih.gov/30263937
https://pubmed.ncbi.nlm.nih.gov/30263937
Publikováno v:
The Journal of Experimental Medicine
The molecular mechanisms that regulate AID mutator activity at off-target genes are not well characterized. Mu et al. show AID phosphorylation dynamically controls activity at Myc and other sites. Pharmacological induction of AID phosphorylation lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09db9394fa949ffdae3642282e1f89f
https://pubmed.ncbi.nlm.nih.gov/29122947
https://pubmed.ncbi.nlm.nih.gov/29122947